{"title":"All Products","description":"","products":[{"product_id":"transformers®-starscream-protron","title":"Transformers® Starscream Protron with Whey + Casein Blend","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eWhey + Casein Blend\u003c\/strong\u003e\u003cbr\u003eSustained release for optimal recovery and growth.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdded MCTs\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eHealthy source of fats as well as adds to creamy texture.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDigestive Enzymes\u003c\/strong\u003e\u003cbr\u003e\u003cmeta charset=\"utf-8\"\u003e \u003cspan\u003eSupports healthy nutrient breakdown.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp class=\"p1\"\u003eThe \u003cb\u003ePROTRON\u003c\/b\u003e supplement is emblematic of the strength and resilience of the TRANSFORMERS\u003cspan class=\"s1\"\u003e\u003csup\u003e®\u003c\/sup\u003e\u003c\/span\u003e robots, offering a high-powered protein blend that's as strong and versatile as the characters themselves. With a delicious flavor and formula designed to support muscle growth and recovery, PROTRON can help you build and maintain your power.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eProtein powders need to – or at least should – have a purpose: to improve recovery times, and ultimately, body composition. But how does that occur? Or more specifically, what needs to happen in the body to recover from a workout, and subsequently improve body composition. To sum it up with one phrase, net protein balance needs to be positive.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eWhen you vigorously train or exert yourself, a process called protein degradation (the breakdown of muscle protein) begins so that the body can fuel itself, and a process called muscle protein synthesis (the creation of muscle protein) slows down. Think of this like shutting off your engine (protein synthesis), to fuel your car (muscle protein breakdown). As this entire process plays out, the available pool of amino acids in skeletal muscle depletes, as they too are drawn in and broken down in the natural, catabolic process during exercise training.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eWhile this situation is quite adequate during a training session, it’s precisely the opposite of what we want afterwards. At that point, we want the available pool of amino acids to increase, protein degradation to slow or stop, and muscle protein synthesis to increase. Enter protein supplements. Protein powders are a quick, convenient way to rapidly increase the available pool of amino acids in skeletal muscle.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eHowever, not all proteins are created equal when assessed within the matrix of molecular triggers, enzymes, and amino acids that constitute skeletal muscle protein synthesis. Low quality blends, fillers, masking agents, and the like reduce the net protein content of many protein products, ultimately reducing lean muscle impact.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eA quality protein supplement not only contains a high amount of protein, but the protein sources from which it draws need to be themselves high quality – and the benefit a particular protein source has can be assessed by analyzing its amino acid profile. Human skeletal muscle makes the most use out of a few amino acids (the BCAAs among them), and so a quality protein needs to have an amino acid profile that is optimal for this context.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eWe chose the protein blend for PROTRON with optimization in mind. Our mix of cold-processed undenatured whey protein concentrate, crossflow microfiltered whey protein isolate, and milk protein isolate has a complete amino acid profile that has been shown in research to increase nitrogen retention, lean muscle impact, and satiating ability (the feeling of fullness). This blend has also been specifically configured to provide both rapid \u003ci\u003eand\u003c\/i\u003e sustained additions to your body’s amino acid profile – meaning your recovery is not only supported immediately after a session, when you most need it, but over time as well.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eBest of all, we have a \u003ci\u003efully transparent \u003c\/i\u003elabel for PROTRON. Meaning that not only do we disclose the protein sources themselves and their specific yields, but we have also disclosed the entire formula’s amino acid profile. You can see, for example, that each serving yields a full 2.6g of leucine – a leucine dose supported in the literature to maximally increase muscle protein synthesis.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eHere is a more complete breakdown of each protein source:\u003c\/p\u003e\n\u003cp class=\"p3\"\u003e\u003cb\u003eCold-processed undenatured whey protein concentrate\u003c\/b\u003e: Whey protein concentrate is probably the most common form of whey protein you will find. However, how it is processed is where the benefit truly lies. This process of cold processed undenaturization preserves the molecular structure of the amino acid particles as well as the immune boosting benefits that it contains. This undenatured protein is also a rich source of amino acids, including those needed for the synthesis of glutathione, which is an important antioxidant that can be depleted by stress (exercise stress included). This makes it a great foundation for your post workout recovery nutrition.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003e\u003cb\u003eCrossflow microfiltered whey protein isolate:\u003c\/b\u003e \u003cbr\u003eWhey protein isolate is an extremely “clean” form of whey protein. It yields a higher number of amino acids, half of which are from the essential amino acids (cannot be made by the body). Microfiltration eliminates a large majority of the fat and lactose from the whey, which makes it easily digestible and quickly absorbed into the body. This crossflow process uses a highly intricate method to isolate the protein. It is not subjected to chemicals and is thus left in its most natural state.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003e\u003cb\u003eMilk Protein Isolate:\u003c\/b\u003e \u003cbr\u003eMilk protein isolate is obtained through the partial removal of non-protein materials from skim milk (lactose and other minerals). What you are left with is a dry product that contains more than 90% protein by weight. This product contains both casein and whey proteins in their original proportions found in milk, without combining separately produced casein and whey proteins. It contains very little fat and lactose and has a very high amino acid composition making it a perfect addition to this blend.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eThis blend has also been specifically configured to provide both rapid and sustained additions to your body’s amino acid profile – meaning your recovery is not only supported immediately after a session but will also carry you to your next meal. On top of that, our flavors are out of this world! We’ve also boosted this protein blend with digestive enzymes that will provide you with all the confidence that those nutrients you just supplied your body with will do their part in your quest for the optimal result!\u003c\/p\u003e\n\u003cp class=\"p3\"\u003e\u003cspan class=\"s2\"\u003e\u003cb\u003eDigeSEB\u003c\/b\u003e\u003c\/span\u003e\u003cspan class=\"s3\"\u003e\u003cb\u003e\u003csup\u003e®\u003c\/sup\u003e\u003c\/b\u003e\u003c\/span\u003e\u003cspan class=\"s2\"\u003e\u003cb\u003e Digestive enzyme blend:\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eOne can easily make the argument that dietary enzymes – and digestive enzymes – are the most consistently underrated and overlooked component to a supplementation regimen. These powerful little protein structures influence or outright control a vast, complex network of bodily functions. In a fitness-specific context, digestive enzymes play a crucial role in the breaking down of dietary carbohydrates, fats, and proteins into their constitutive parts, and therefore allow your body to use them in various processes (glycogenesis, protein synthesis, etc.).\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eDespite their critical function, many supplement companies overlook the necessity of digestive enzymes and do not include sufficient levels (and kinds) of enzymes in their products. For a whey product, in particular – a compound that requires \u003ci\u003esignificant \u003c\/i\u003edigestion and breakdown – this is madness.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eAs usual, we take a much more comprehensive, clinical approach than the average. In the PROTRON supplement, we have included a digestive enzyme blend called DigeSEB\u003cspan class=\"s1\"\u003e\u003csup\u003e®\u003c\/sup\u003e\u003c\/span\u003e comprised of amylases, proteases, lactases, amylases, and cellulases, allowing for a full and complete breakdown of all PROTRON’s components. Research suggests that whey absorption through the blood is heavily impacted by its gastric digestibility. Using DigeSEB\u003cspan class=\"s1\"\u003e\u003csup\u003e®\u003c\/sup\u003e\u003c\/span\u003e ensures that the protein – along with its milk and whey sugars and fats – are completely broken down.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eDigeSEB\u003cspan class=\"s1\"\u003e\u003csup\u003e®\u003c\/sup\u003e\u003c\/span\u003e ensures that the PROTRON supplement not only provides gourmet taste and clinical ingredients within the protein itself, but that your protein also increases the effectiveness of your pre- and post-workout nutrition in general.\u003c\/p\u003e\n\u003cp class=\"p5\"\u003e\u003cspan class=\"s2\"\u003e\u003cb\u003eCoconut Oil Creamer (Medium Chain Triglycerides):\u003cbr\u003e\u003c\/b\u003e\u003c\/span\u003eCoconut oil made of 100% Medium chain triglycerides has been shown to have the greatest health benefits. MCTs are made up of a chemical structure that allows them to quickly and effectively bypass gastric uptake for transport directly to the liver for oxidation and then used for energy. Their unusual chemical structure and metabolic process has resulted in MCTs being a focus for a wide range of therapeutic and exercise supplement uses.\u003c\/p\u003e\n\u003cp class=\"p5\"\u003eIn the context of exercise science, recent research has shown that MCTs significantly (up to 65%) increase resting energy expenditure, along with dose-dependently reducing fatty acid deposition in adipose tissue. These results suggest that MCTs are effectively increasing the body’s metabolic response to food intake.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/TF-Protron-MixedBerryCheesecake-17x4.75.pdf?v=1726132935\"\u003eMixed Berry Cheesecake Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/TF-Protron-PBCookiesNCream-17x4.75.pdf?v=1726133568\"\u003ePB Cookies 'N Cream Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/TF-Protron-VanillaHoneyGraham-17x4.75.pdf?v=1726133292\"\u003eVanilla Honey Graham Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003ch3 class=\"p7\"\u003e\u003cspan class=\"s2\"\u003e\u003cb\u003eReferences:\u003c\/b\u003e\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"p7\"\u003e\u003cspan class=\"s2\"\u003e\u003cb\u003e\u003cbr\u003e\u003c\/b\u003e\u003c\/span\u003eBabayan, V. K. (1987) Medium-chain triglycerides and structured lipids. Lipids 22:417-420.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eBach, A. C. \u0026amp; Babayan, V. K. (1982) Medium-chain triglycerides: an update. Am. J. Clin. Nutr. 36:950-962.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eScalfi, L, Coltorti, A. \u0026amp; Contaldo, F. (1991) Postprandial thermogenesis in lean and obese subjects after meals supplemented with medium-chain and long-chain triglycerides. Am. J. Clin. Nutr. 53:1130-1133.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eSeaton, T. B., Welle, S. L, Warenko, M. K. \u0026amp; Campbell, R. G. (1986) Thermic effect of medium-chain and long-chain triglycerides in man. Am. J. Clin. Nutr. 44:630-634.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eDulloo, A. G., Fathi, M., Mensi, N. \u0026amp; Girardier, L. (1996) Twenty-four-hour energy expenditure and urinary catecholamines of humans consuming low-to-moderate amounts of medium-chain triglycerides: a dose-response study in human respiratory chamber. Eur. J. Clin. Nutr. 50:152-155.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eFlatt, J. P., Ravussin, E., Acheson, K. J. \u0026amp; Jequier, E. (1985) Effects of dietary fat on postprandial substrate oxidation and on carbohydrate and fat balances. J. Clin. Investig. 76:1019-1024.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eHill, J. O., Peters, J. C., Yang, D., Sharp, T., Kaler, M., Abumrad, N. N. \u0026amp; Greene, H. L. (1989) Thermogenesis in humans during overfeeding with medium-chain triglycerides. Metabolism 38:641-648\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eWhite, M. D., Papamandjaris, A. A. \u0026amp; Jones, P.J.H. (1999) Enhanced postprandial energy expenditure with medium-chain fatty acid feeding is attenuated after 14 d in premenopausal women. Am. J. Clin. Nutr. 69:883-889.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eAstbury NM, et al. Dose-response effect of a whey protein preload on within-day energy intake in lean subjects. Br J Nutr. (2010)\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eFrestedt JL, et al. A whey-protein supplement increases fat loss and spares lean muscle in obese subjects: a randomized human clinical study. Nutr Metab (Lond). (2008)\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eZhu K, et al. The effects of a two-year randomized, controlled trial of whey protein supplementation on bone structure, IGF-1, and urinary calcium excretion in older postmenopausal women. J Bone Miner Res. (2011)\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eRennie MJ, et al. Control of the size of the human muscle mass. Annu Rev Physiol. (2004)\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eAnabolic signalling deficits underlie amino acid resistance of wasting, aging muscle\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eNutrient signalling in the regulation of human muscle protein synthesis\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eLeucine supplementation improves muscle protein synthesis in elderly men independently of hyperaminoacidaemia\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eTang JE, et al. Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men. J Appl Physiol. (2009)\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eWhey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older men\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eDangin M, et al. The digestion rate of protein is an independent regulating factor of postprandial protein retention. Am J Physiol Endocrinol Metab. (2001)\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eEngelen MP, et al. Casein protein results in higher prandial and exercise induced whole body protein anabolism than whey protein in Chronic Obstructive Pulmonary Disease. Metabolism. (2012)\u003c\/p\u003e\n\u003cp class=\"p3\"\u003ePal S, Ellis V, Dhaliwal S. Effects of whey protein isolate on body composition, lipids, insulin and glucose in overweight and obese individuals. Br J Nutr. (2010)\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eHaraguchi FK, et al. Evaluation of biological and biochemical quality of whey protein. J Med Food. (2010)\u003c\/p\u003e\n\u003cp class=\"p3\"\u003ede Aguilar-Nascimento JE, Prado Silveira BR, Dock-Nascimento DB. Early enteral nutrition with whey protein or casein in elderly patients with acute ischemic stroke: a double-blind randomized trial. Nutrition. (2011)\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eCandow DG, et al. Effect of whey and soy protein supplementation combined with resistance training in young adults. Int J Sport Nutr Exerc Metab. (2006)\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Milk Chocolate Cookies 'n Cream (Starscream)","offer_id":53256707047734,"sku":"850057789645","price":228.57,"currency_code":"AED","in_stock":true},{"title":"Mixed Berry Cheesecake (Optimus Prime)","offer_id":53256707080502,"sku":"850057789447","price":228.57,"currency_code":"AED","in_stock":true},{"title":"PB Cookies 'N Cream (Megatron)","offer_id":53256707113270,"sku":"850057789461","price":228.57,"currency_code":"AED","in_stock":true},{"title":"Vanilla Honey Graham (Bumblebee)","offer_id":53256707146038,"sku":"850057789454","price":228.57,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/PROTRON_MILKCHOCOLATE_FRONT.png?v=1762807359"},{"product_id":"transformers®-starscream-allspark","title":"Transformers® Starscream Allspark Energy \u0026 Performance Supplement","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eFull Blend of Electrolytes\u003c\/strong\u003e - Can replace key electrolytes lost during intense training.*\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFull Serving of EAAs\u003c\/strong\u003e - Can Support recovery and muscle protein synthesis.*\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eElevATP®\u003c\/strong\u003e - Can increase levels of endogenous ATP.*\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eVitamin C (as ascorbic acid)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eVitamin C is historically best-known for the treatment and prevention of scurvy, though it has many other roles in the body. For example, vitamin C catalyzes or is a cofactor in eight enzymatic reactions involved in the synthesis of collagen, the nutrient carnitine, and several neurotransmitters necessary for the proper function of the brain.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIn the contemporary context, vitamin C is best known as a potent antioxidant. In addition to its intrinsic activity as an antioxidant, vitamin C has been shown in in vitro trials to regenerate alpha-tocopherol (vitamin E). As an antioxidant, vitamin C combats the detrimental effects of a group of compounds called radical oxygen species that, when produced, degrade the lipid membrane of the cell and may cause internal damage. By “scavenging” these free radicals, vitamin C and other antioxidants form a defense against excess cellular damage.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eCalcium (as calcium carbonate, calcium citrate, dicalcium malate (DimaCal®)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWhile best-known as the main bioactive in milk, and a compound that contributes to strong bones, calcium has numerous physiological effects in the body. As a key electrolyte it is responsible for mediating vascular contraction and vasodilatation, muscle function, nerve transmission, intracellular signaling, and hormonal secretion. Homeostatic regulation of calcium, which the body cannot produce, also requires sufficient levels of vitamin D. In the context of muscular contraction and relaxation, if calcium is required for strong contractions, magnesium is required for efficient relaxation of those muscle fibers.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eDimaCal®\u003cstrong\u003e \u003c\/strong\u003eis a trademarked form of dicalcium malate, which is calcium bonded with malic acid. It has been shown in studies to be a much better absorbed form of calcium and can maintain serum calcium levels for a much longer period. This can lead to a better maintained electrolyte level and greater performance where calcium is required.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eMagnesium (as magnesium carbonate, magnesium citrate, magnesium bisglycinate chelate, magnesium chloride, magnesium lysinate glycinate chelate)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eMagnesium, an often-overlooked electrolyte, is the second most abundant intracellular cation (after potassium). It is a cofactor to over three hundred enzymatic reactions in the body and is required for cellular energy metabolism, functioning of the sodium\/potassium adenosine triphosphatase pump, nerve conduction, and ion transport. Magnesium is also required for the use of the body’s energy currency, ATP. To become biologically active, ATP must be bound to magnesium to form Mg-ATP. In addition, magnesium is necessary for the proper function of cells with calcium and potassium gated ion channels such as heart and muscle cells. Working alongside calcium, magnesium plays a crucial role in the body by regulating muscular contractions as well as cramp prevention. In the context of muscle health and rehydration, the longer and more intense a bout of physical activity is, the more magnesium is lost primarily through sweat and urine. This loss of electrolyte balance requires its replenishment so that physical performance can remain at its peak throughout the duration of the activity reducing the risk of injury or bodily harm. Regardless of the type of sport or exercise, muscular contractions and energy production could not occur consistently without the presence of magnesium.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eZinc (as zinc bisglycinate chelate)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eAs an essential mineral, like magnesium, zinc is also involved in a wide range of essential biological functions in the human body – and a requirement in the catalytic activity of over one hundred enzymes.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eMost notably, zinc is vital for immune function, protein synthesis, cellular division, and DNA synthesis. For immune function, zinc is required for the function of a group of immune cells known as neutrophils and macrophages, which eliminate pathological cells and their products from the body.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWith magnesium, sufficient levels of zinc are also necessary for the production and maintenance of healthy levels of testosterone.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eChloride (as magnesium chloride)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eChloride is one of the most important electrolytes in the human body. Like sodium and potassium, which will be discussed below, chloride creates specific channels in cell membranes which help to carry out different vital tasks. It is responsible for balancing the fluids on the inside of the cells with the fluids on the outside of the cells, as well as maintaining proper blood volume, blood pressure, and fluid pH. Chloride is also important for muscle and heart contraction as well as to aid in the carrying of nerve impulses between our nerve cells and our brain and the rest of the body. Additionally, chloride is needed to help red blood cells exchange oxygen and carbon dioxide in the lungs as well as playing a role in the digestion of foods by supporting hydrochloric acid production in the stomach. We often lose chloride through sweat and perspiration, which comes in the form of water and salt. Replenishment of chloride can come from utilizing salt (often found as sodium-chloride, or table salt), cheese, canned fish, and some processed meats. Overconsumption of some of these foods may not be beneficial for some individuals, so supplementation may be the best way for these individuals to replenish chloride in their bodies.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eSodium (as sodium citrate, sodium bicarbonate)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eSodium, like chloride above, is one of the most essential electrolytes for our body to utilize. As sodium is often found bound to chloride as sodium-chloride (salt), their function and benefits are going to be very similar in nature. Sodium helps to keep the water (amount of fluid outside of the body’s cells) and electrolyte balance of the body, while also aiding in the contraction and relaxation of muscles as well as conducting nerve impulses. While only 500mg of sodium is needed per day for these functions to occur, we as active individuals need far more sodium to maintain these functions. We mostly lose sodium through sweat and urine, so the more active we are\/the more we sweat and the more we urinate, the more sodium is lost. Acquiring enough sodium through food and drink is crucial to establishing equilibrium again to maintain proper functioning and electrolyte balance within the body. The standard American diet is often overloaded with sodium and coupled with inactivity, which can lead to poor health and dysfunction. It is important to engage in physical activity of some kind most days and to eat a diet that is balanced in nutrients to maintain proper health. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003ePotassium (as potassium citrate, coconut water concentrate, potassium glycinate complex)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePotassium, as sodium’s counterpart, acts as a critical electrolyte primarily by helping to maintain normal levels of fluids inside of our cells. Additionally, it helps muscles to contract and relax, aid in strong nerve function, as well as support normal blood pressure. It works very closely with sodium to create the membrane potential needed for the electrical currents that generate these functions to pass from one cell to the next. While the potassium levels in our body are regulated carefully, a diet lacking enough potassium (especially when combined with excess sodium) or one that contains too much potassium can eventually lead to certain types of dysfunctions and poor health status. When potassium levels in the body increase, the adrenal glands release the hormone aldosterone, which causes the kidneys to excrete excess potassium through the urine. When potassium levels are too low, aldosterone levels are suppressed, which can lead to conservation of potassium thus interfering with balance and negatively affecting transport channels that affect vital bodily functions. Potassium can be gotten from the diet in the form of fresh fruits and vegetables, such as sweet potatoes, beans, tomatoes, spinach and broccoli but supplementing can be an essential application as well to support an active lifestyle where excretion is higher than can be replenished through diet.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eVegan Fermented BCAA\/EAA Blend (5g)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIf one were to think of the body as a construction project, amino acids would be the most basic building materials: raw lumber, mortar, bricks, and so on. While the assembly of these building blocks is of course critically important to the function of the building – and one of the amino acids, leucine, controls its own assembly – the quality and availability of the materials themselves is more important. Not enough concrete? The foundation cracks and the building falls.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eYour body is the exact same way. It is comprised of various amino acids, both essential and non-essential, that comprise the cellular basis of each cell in your body. When it comes down to skeletal muscle, the most important are the EAAs – or essential chained amino acids. Comprised of nine amino acids, these compounds effectively control the rate at which your muscle grows (hypertrophies), its contractile force, its endurance, and so on – to say they are massively important is an understatement. For this reason, they form the basis of any competently designed supplement protocol.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCollectively, as stated above, the essential amino acids are famous for their role in skeletal muscle protein synthesis and metabolism. Of the nine, leucine is both the most physiologically important with respect to muscle mass, and the most extensively studied. Data on leucine demonstrate this amino acid plays critical roles in stimulating skeletal muscle protein synthesis, and ribosomal biogenesis and assembly (the literal building of muscle tissue), along with playing a lesser role in insulin signaling and gluconeogenic processes. As a result of these diverse roles, leucine has been demonstrated to significantly stimulate skeletal muscle protein synthesis, and attenuate protein degradation, by both insulin-mediated and non-insulin mediated mechanisms.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eLeucine’s insulin-mediated effects are the result of its activation of the classical insulin receptor substrate (IRS)\/phosphatidylinositol (PI) 3-kinase (PI3K)\/Akt\/mTOR signal transduction pathway. In this pathway, the bonding of a substrate (glucose) eventually activates a compound known as Akt. Once phosphorylated and activated, Akt signals the release of the famous mammalian target of rapamycin (mTOR). mTOR then increases the translation of muscle-cell ribosomal proteins that increase ribosome biogenesis, which is the literal production of proteins. Leucine has additionally been shown to positively regulate protein synthesis independent of insulin. In certain trials where rapamycin and leucine were co-administered, rapamycin showed only partial inhibition of leucine’s effects on muscle protein synthesis.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIn more practical terms, there is a significant body of evidence demonstrating the positive effect of amino acids on athletic performance. Extensive studies in exercise-trained populations reveal that, collectively, amino acids may:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eReduce total muscle soreness after intense resistance training, and\/or further delay its onset.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eDecrease muscle recovery time between bouts of intense resistance exercise training.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli aria-level=\"1\" dir=\"ltr\"\u003e\n\u003cp role=\"presentation\" dir=\"ltr\"\u003e\u003cspan\u003eIncrease lean body mass when used daily, in conjunction with diet and exercise.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eL-Taurine\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eThrough traditionally referred to as an amino acid due to its chemical structure, taurine is not an amino acid in the sense that leucine, alanine, or glutamine are. Its chemical status aside, taurine is considered one of the body’s most essential chemical compounds, as cardiovascular function, muscle development and function, along with optical and nervous systems in the body depend on its abundance. While data on taurine typically occurs with taurine in supplement combinations (with caffeine and other amino acids), these data nevertheless suggest that dietary supplementation with taurine may have beneficial effects on mental focus and alertness and may assist during times of increased physical exertion.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eCoconut Water Concentrate (Cocos nucifera)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCoconut water, like the name implies, is the liquid that is found within the coconut itself. Often having a slightly sweet, nutty flavor, it also contains an adequate number of vitamins, minerals, and electrolytes like potassium, sodium, and magnesium. All these electrolytes, like discussed in sections above, can help to boost hydration status and replenish nutrients lost through exercise or rigorous everyday activities. Potassium is the highest concentration in coconut water at 600mg per cup (16% DV), which as discussed about it has a vital role in optimally functioning kidneys and strong muscle contractions. Potassium can also work to keep fluid levels and other electrolytes balanced during exercise. The high concentration of potassium in coconut water specifically can balance our sodium’s effects on blood pressure, and even lower blood pressure slightly, which can have its own benefits towards training and overall health and circulatory health. In addition to the added electrolytes that coconut water can provide, it also can provide a potent number of antioxidants that can aid in the neutralization of free radicals that can rapidly take over during intense training. By eliminating these free radicals, muscles will be able to perform longer and more efficiently, as well as be able to recover adequately. While general water consumption can be adequate as well, the added electrolytes coconut water can supply provides an added benefit that can improve performance and overall recovery.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eElevATP® (Ancient Peat Extract and Apple Extract)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eAdenosine triphosphate and other ATP metabolites are involved in a number of biological processes including cardiac function, blood flow, muscle contraction and neurotransmission. ATP is the primary molecule that acts as a carrier for energy within cells. It has also often been studied that increased levels of ATP have shown increases in health and performance. Supplementation with exogenous ATP has often shown its ability to increase ATP concentrations in blood. Oral supplementation with ancient peat and apple extracts have exhibited their ability to increase intracellular and intramuscular ATP levels. ElevATP® is a blend these specific polyphenols that can work to increase endogenous ATP levels without a simultaneous increase in serum lactate. The significance of this is that usually with an increase in endogenous ATP there is an increase in intracellular free radicals. When these free radicals are not present, oxidative stress is mitigated and there is more potential for the beneficial increases in ATP to take center stage. These increases of ATP are essential as when available energy is increased it can have positive benefits in terms of increased power, strength, and overall exercise performance. One study looked at dosing ElevATP® against placebo and showed that the group who received ElevATP® saw a blood ATP increase of 45% on average along with no increase in oxidative blood glucose. This type of result has been shown repeatedly in studies and has given ElevATP® the reputation to be a beneficial compound for the goals of improving endurance, strength, power, and other training specific adaptations.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eIonic Trace Minerals (as Concentrace® AC)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eOur bodies are high functioning machines and require a lot of support to continue to perform at a high-level day in and day out. A lot of these needs are difficult to be acquired by diet alone, so supplementation is critical. Minerals are included in these daily needs and are vital to the body’s many processes. ConcenTrace® AC is a high-quality trace mineral complex providing a comprehensive blend of nutrients that are often hard to acquire from diet alone. Its manufacturing process makes it up to 26x more concentrated than other colloidal trace minerals, adding to its benefits. These minerals contained in the product are catalysts for all the vitamins and other nutrients our body requires to function at an optimal level and maintain health. Some of these functions include electrolyte replacement, maintaining pH balance in the body, nourishing hair and skin, strengthening bones and joints, regulating the digestive system, and improving athletic performance.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eAstraGin® (Astragalus membranaceous and Panax notoginseng root extracts)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eAstraGin® is a trademarked combination of \u003c\/span\u003e\u003cspan\u003eAstragalus membranaceous\u003c\/span\u003e\u003cspan\u003e and \u003c\/span\u003e\u003cspan\u003ePanax notoginseng\u003c\/span\u003e\u003cspan\u003e that has been widely used in the supplement manufacturing industry for due to its clinically studied benefits for improving absorption of nutrients, peptides, and amino acids. Some statistics include increased absorption of creatine, leucine, citrulline, and other peptides by up to 67%, increased curcumin absorption by 92%, increases polyunsaturated fatty acids (from flax and fish oil) by 58% and 100% respectively, as well as can increase ATP production in the liver by 18%. AstraGin® has been shown capable of increasing muscle protein synthesis and increased mTOR through enhanced leucine absorption, which has an influence on improved glucose metabolism and mitochondrial functions. In addition to this benefit, AstraGin’s® ability to enhance polyunsaturated fatty acid absorption while also inhibiting saturated fatty acid absorption, thus reducing the risk of impaired glucose metabolism and mitochondrial function, can enhance ATP synthesis through mitochondrial respiration, and increase oxidative phosphorylation.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIt has been further studied how Astragalus and \u003c\/span\u003e\u003cspan\u003ePanax notoginseng\u003c\/span\u003e\u003cspan\u003e specifically can protect mitochondria and enhance their function towards anti-aging. The proposed mechanism leads to Astragalus acting as a free radical scavenger, which can inhibit mitochondrial permeability transition and increase the activity of antioxidants against the peroxidation of membrane lipids. \u003c\/span\u003e\u003cspan\u003ePanax notoginseng\u003c\/span\u003e\u003cspan\u003e also works in a similar fashion through decreased free radical production. This lipid peroxidation has been shown to be a major cause of decreases in mitochondrial function. In addition to this, ensuring a highly permeable environment around the mitochondrial membrane is crucial for maintaining mitochondrial functions. This permeability allows for the passage of key electro chemicals to cross the gradient allowing for the process of energy development for the cells.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/TF-Allspark-MixedBerryKiwi-11.25x5.25.pdf?v=1726131233\"\u003e\u003cspan\u003eMixed Berry Kiwi Label\u003c\/span\u003e\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/TF-Allspark-SourLemonCandy-11.25x5.25.pdf?v=1726131325\"\u003e\u003cspan\u003eSour Lemon Candy Label\u003c\/span\u003e\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/TF-Allspark-BloodOrangePassionFruit-11.25x5.25.pdf?v=1726131611\"\u003e\u003cspan\u003eBlood Orange Passion Fruit Label\u003c\/span\u003e\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/REFFERENCES-Transformers-Allspark.pdf?v=1727078181\" target=\"_blank\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Grape Lemonade (Starscream)","offer_id":53256707473718,"sku":"850057789638","price":209.52,"currency_code":"AED","in_stock":true},{"title":"Mixed Berry Kiwi (Optimus Prime)","offer_id":53256707506486,"sku":"850057789416","price":209.52,"currency_code":"AED","in_stock":true},{"title":"Sour Lemon Candy (Bumblebee)","offer_id":53256707539254,"sku":"850057789423","price":209.52,"currency_code":"AED","in_stock":true},{"title":"Blood Orange Passion Fruit (Megatron)","offer_id":53256707572022,"sku":"850057789430","price":209.52,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/ALLSPARK_GRAPELEMONADE_FRONT.png?v=1762807362"},{"product_id":"iso-clear-bag-whey-protein-isolate","title":"Fun Sweets® Iso Clear","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e20G Protein\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eZero Sugar\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eRefreshing Taste\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eLactose Free\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eWe all know that whey protein is one of the most utilized protein sources on the market. With its convenient nature and wide variety of flavors that it can take on, it is a common and popular option for many people looking to put on muscle or just increase their overall protein intake. Unfortunately, with whey protein classically having a milky taste, it lends itself useful for taking on primarily sweet, dessert like flavors, like chocolates, vanillas, peanut butters, and other classic ice cream varieties. Recently there has been an uptick in innovation in the whey protein category with the introduction of clear whey protein isolate.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eWhat is clear whey? Clear whey isolate is a modern twist on traditional whey protein, designed for those who prefer a lighter, more refreshing protein supplement. Unlike standard whey protein powders, which typically have a creamy, milkshake-like consistency, clear whey isolate is formulated to mix into a translucent, juice-like beverage. This makes it an appealing option for those who enjoy fruit-flavored drinks and want to avoid the heavier texture of regular protein shakes.\u003c\/p\u003e\n\u003cp\u003eOne of the key benefits of clear whey isolate is its high protein content coupled with its low calorie, low carb, and low-fat profile. It is derived from whey protein isolate, which is processed to remove most of the lactose, fat, and carbs, leaving behind a protein-rich product that is easy to digest and absorb. This makes it an excellent option for those looking to increase their protein intake without adding unnecessary calories or dealing with the digestive discomfort that can sometimes accompany dairy-based products.\u003c\/p\u003e\n\u003cp\u003eClear whey isolate is particularly well-suited for post-workout recovery, as it provides a quick and efficient source of protein to support muscle repair and growth. Its light, refreshing taste makes it easy to consume immediately after a workout, especially on hot days when a heavy, creamy shake might not be as appealing. Additionally, because it mixes into a clear liquid, it can be a convenient way to stay hydrated while also meeting your protein needs.\u003c\/p\u003e\n\u003cp\u003eOverall, clear whey isolate offers a versatile and enjoyable way to incorporate high-quality protein into your diet. Whether you're looking to build muscle, recover from intense training, or simply maintain your daily protein intake, clear whey isolate provides a refreshing alternative to traditional protein supplements.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/ISO_CLEAR.png?v=1754307372\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Frame_2_0505d42a-a8c3-4956-94b2-cf662aec89fa.png?v=1754307245\"\u003eFun Sweets® Blue Raspberry\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Frame_1.png?v=1754307245\"\u003eFun Sweets® Cherry Berry\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Frame_3.png?v=1754307244\"\u003eFun Sweets® Orange Cream\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eCooke, M. B., Rybalka, E., Stathis, C. G., Cribb, P. J., \u0026amp; Hayes, A. (2010). Whey protein isolate attenuates strength decline after eccentrically-induced muscle damage in healthy individuals. Journal of the International Society of Sports Nutrition, 7, 30. https:\/\/doi.org\/10.1186\/1550-2783-7-30\u003c\/p\u003e\n\u003cp\u003eBrown, M. A., Stevenson, E. J., \u0026amp; Howatson, G. (2018). Whey protein hydrolysate supplementation accelerates recovery from exercise-induced muscle damage in females. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 43(4), 324–330. https:\/\/doi.org\/10.1139\/apnm-2017-0412\u003c\/p\u003e\n\u003cp\u003eLevenhagen DK, et al. Postexercise protein intake enhances whole- body and leg protein accretion in humans . Med Sci Sports Exerc. (2002)\u003c\/p\u003e\n\u003cp\u003eHulmi JJ, et al. Resistance exercise with whey protein ingestion affects mTOR signaling pathway and myostatin in men . J Appl Physiol. (2009)\u003c\/p\u003e\n\u003cp\u003eHulmi JJ, et al. Acute and long-term effects of resistance exercise with or without protein ingestion on muscle hypertrophy and gene expression. Amino Acids. (2009)\u003c\/p\u003e\n\u003cp\u003eBunn JA, et al. Protein and Amino Acid Supplementation Does Not Alter Proteolytic Gene Expression following Immobilization. J Nutr Metab. (2011)\u003c\/p\u003e\n\u003cp\u003eYang Y, et al. Resistance exercise enhances myofibrillar protein synthesis with graded intakes of whey protein in older men . Br J Nutr. (2012)\u003c\/p\u003e\n\u003cp\u003eMoore DR, et al. Resistance exercise enhances mTOR and MAPK signalling in human muscle over that seen at rest after bolus protein ingestion . Acta Physiol (Oxf). (2011)\u003c\/p\u003e\n\u003cp\u003eBiolo G, et al. An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein . Am J Physiol. (1997)\u003c\/p\u003e\n\u003cp\u003eBurd NA, et al. Enhanced amino acid sensitivity of myofibrillar protein synthesis persists for up to 24 h after resistance exercise in young men. J Nutr. (2011)\u003c\/p\u003e\n\u003cp\u003eMoore DR, et al. Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men. Am J Clin Nutr. (2009)\u003c\/p\u003e\n\u003cp\u003eHoffman JR, et al. Effect of protein-supplement timing on strength, power, and bodycomposition changes in resistance-trained men. Int J Sport Nutr Exerc Metab. (2009)\u003c\/p\u003e\n\u003cp\u003eAndersen LL, et al. The effect of resistance training combined with timed ingestion of protein on muscle fiber size and muscle strength. Metabolism. (2005)\u003c\/p\u003e\n\u003cp\u003eHartman JW, et al. Consumption of fat-free fluid milk after resistance exercise promotes greater lean mass accretion than does consumption of soy or carbohydrate in young, novice, male weightlifters. Am J Clin Nutr. (2007)\u003c\/p\u003e\n\u003cp\u003eWeisgarber KD, Candow DG, Vogt E SM. Whey Protein Before and During Resistance Exercise Has No Effect on Muscle Mass and Strength in Untrained Young Adults . Int J Sport Nutr Exerc Metab. (2012)\u003c\/p\u003e\n\u003cp\u003eKerksick CM, et al. The effects of protein and amino acid supplementation on performance and training adaptations during ten weeks of resistance training. J Strength Cond Res. (2006)\u003c\/p\u003e\n\u003cp\u003eKukuljan S, et al. Effects of resistance exercise and fortified milk on skeletal muscle mass, muscle size, and functional performance in middle-aged and older men: an 18-mo randomized controlled trial. J Appl Physiol. (2009)\u003c\/p\u003e\n\u003cp\u003eCandow DG, et al. Protein supplementation before and after resistance training in older men . Eur J Appl Physiol. (2006)\u003c\/p\u003e\n\u003cp\u003eWeinheimer EM, et al. Whey protein supplementation does not affect exercise traininginduced changes in body composition and indices of metabolic syndrome in middle-aged overweight and obese adults. J Nutr. (2012)\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Fun Sweets® Cherry Berry","offer_id":53256714551606,"sku":"850057789744","price":228.57,"currency_code":"AED","in_stock":true},{"title":"Fun Sweets® Orange Cream","offer_id":53256714584374,"sku":"850057789751","price":228.57,"currency_code":"AED","in_stock":true},{"title":"Fun Sweets® Blue Raspberry","offer_id":53256714617142,"sku":"850057789737","price":228.57,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/ISOCLEAR_RASP_FRONT.png?v=1762807386"},{"product_id":"fun-sweets-r-pre-essential-pre-workout","title":"Fun Sweets® Pre","description":"\u003cp\u003e\u003cstrong\u003eTHE ULTIMATE ESSENTIAL PRE-WORKOUT\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eMaximizes performance and endurance with clinically studied doses of L-Citrulline, Beta Alanine, and Betaine Anhydrous.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eCan enhance focus, energy, and mind-muscle connection through the powerful combination of Acetyl L-Carnitine, Alpha GPC, and Caffeine.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eImproves nutrient absorption and bioavailability with AstraGin® to unlock the full potential of every ingredient.\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003ciframe width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/mGhE9DoVeys?si=SPHtNsszjTfQv4ei\" title=\"YouTube video player\"\u003e\u003c\/iframe\u003e\u003c\/p\u003e\n\u003cp\u003eCore PRE is the ultimate essential pre-workout designed to fuel your training day in and day out with clinically dosed ingredients to support energy, endurance, and focus. With 200mg of caffeine, it delivers a clean, steady boost of energy making it ideal for daily use. With other ingredients like L-Citrulline to support nitric oxide production and enhanced muscle pumps, beta-alanine for delaying muscle fatigue and enhancing performance, and Alpha-GPC for a cognitive boost enhancing mind-muscle connection and workout intensity. No matter what event you’re training for Core PRE can ensure you stay dialing in, energized, and performing at your best --- every single day.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMagnesium (as magnesium citrate), Sodium (as sodium citrate), Potassium (as potassium citrate)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMagnesium, sodium, and potassium are key electrolytes that play a crucial role in performance, endurance, and recovery. These minerals regulate muscle contractions, nerve function, hydration, and energy production, making them indispensable for athletes and active individuals of any age. A deficiency in any of these electrolytes can lead to fatigue, muscle cramps, and decreased exercise performance. Proper supplementation and replenishment of lost electrolytes can ensure optimal function, allowing the body to perform at its best.\u003c\/p\u003e\n\u003cp\u003eMagnesium, a key player in over 300 enzymatic reactions in the body, including those responsible for energy production and muscle function, supports ATP synthesis, ATP is the body's primary energy source, which helps to fuel muscles during intense and rigorous activity. Magnesium also plays a vital role in neuromuscular transmission and relaxation, helping to reduce muscle cramps and spasms that can hinder performance. Additionally, it can help regulate calcium levels, preventing excessive muscle contractions and promoting smoother movement patterns.\u003c\/p\u003e\n\u003cp\u003eSodium is crucial mineral for fluid balance, hydration, and maintaining blood volume during exercise. It can help retain water within the muscle, ensuring that muscles remain hydrated and capable of sustained contractions during physical activity. Sodium also plays a key role in nerve signaling, allowing efficient communication between the brain and muscles. Without adequate sodium, athletes are more prone to dehydration, dizziness, and muscle fatigue, especially during prolonged or high-intensity workouts where sweat losses are significant.\u003c\/p\u003e\n\u003cp\u003ePotassium works in conjunction with sodium to maintain proper muscle contractions and nerve function. It can help prevent cramps and muscle weakness while also supporting cardiovascular health by regulating heartbeat and blood pressure. Potassium can also aid glycogen storage, ensuring that muscles have a readily available energy source during exercise. A proper balance of potassium and sodium also can prevent excessive water loss, optimizing hydration and endurance.\u003c\/p\u003e\n\u003cp\u003eTogether, magnesium, sodium, and potassium form the foundation of optimal performance by enhancing muscle function, preventing fatigue, and supporting hydration. Ensuring adequate intake of these electrolytes through diet or supplementation can lead to improved endurance, reduced recovery time, and better overall athletic performance.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eL-Citrulline\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCitrulline is a non-essential, non-protein amino acid that forms during the urea cycle and forms ornithine when combined with carbon dioxide. Citrulline is also a critical source of endogenous (natural) arginine, as it is rapidly and efficiently converted to arginine in the vascular endothelium and other tissues.\u003c\/p\u003e\n\u003cp\u003eCitrulline’s benefits have been shown to be greater than its parent compound. While arginine undergoes direct hepatic (liver) metabolism through the enzyme arginase, citrulline bypasses hepatic metabolism entirely and it is delivered straight to the bloodstream. The result is that gut absorption and plasma (blood) bioavailability studies comparing citrulline and arginine have shown two things. First, that citrulline is less readily destroyed and has greater absorption than arginine. Second, that citrulline supplementation increases arginine levels more effectively than arginine supplementation itself.\u003c\/p\u003e\n\u003cp\u003eThis translates to promising results. For example, animal studies show a significant increase in anaerobic performance at a 250mg\/kg\/day serving of citrulline, while studies in humans implicate citrulline in both aerobic and anaerobic performance increases. As a critical part of the urea cycle, citrulline’s performance benefits are thought to be a result of its role in ammonia clearance.\u003c\/p\u003e\n\u003cp\u003eCitrulline is implicated in reducing the oxygen cost of muscle processes, along with increasing the rate of post-exercise ATP and phosphocreatine replenishment. As ATP and phosphocreatine are the body’s ‘exercise fuel,’ this may result in citrulline delaying time to exhaustion in aerobic and anaerobic exercise.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBeta Alanine\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCarnosine is a bit of an odd duck: we know that it is crucial for muscle function, and that dietary sources of carnosine are essential, but we don’t know precisely how it works. Moreover, for decades, we had no idea how to increase intramuscular concentrations, as exogenous carnosine sources degraded in the body so fast as to be effectively useless.\u003c\/p\u003e\n\u003cp\u003eEnter beta-alanine. Simply a different iteration of one of the amino acids that comprises carnosine itself (alanine), beta-alanine has proven to be the most effective means of significantly increasing intramuscular concentrations of carnosine – and therefore of promoting all of carnosine’s various beneficial effects on muscle performance. If that weren’t enough, beta-alanine has also demonstrated beneficial physiological effects independent of its parent compound. In order to understand why, though, we need to first understand some of the basics behind carnosine itself.\u003c\/p\u003e\n\u003cp\u003eCarnosine, a cytoplasmic dipeptide synthesized from the precursors L-histidine and l-alanine, is present in high concentrations in skeletal muscle and plays a pivotal role as a, “chemical buffer” in myocytes (muscle cells). It has long been known that carnosine concentrations are highest in glycolytic, rather than oxidative muscle fibers (roughly speaking, explosive vs., endurance muscle fibers, respectively), and thus long hypothesized that this amino acid is required for sustained performance during supramaximal exercise. Recent research demonstrates that carnosine exerts its physiological effects in long hypoxic (low oxygen) drives by functioning as a high-capacity pH buffer in skeletal muscle, preventing the pH ratio of plasma from dropping too low – and therefore preventing crucial pH-dependent processes such as protein synthesis from being inhibited by acidosis.\u003c\/p\u003e\n\u003cp\u003eDespite its critical role in skeletal muscle anaerobic performance, intramyocellular synthesis of carnosine is rate-limited by the availability of l-alanine. Unfortunately, most literature demonstrates that attempting to increase intramuscular levels of carnosine via either direct carnosine or alanine supplementation is largely ineffective due to carnosine\/alanine pharmacokinetics. Enter beta-alanine. Research with beta-alanine demonstrates consistent and dose-dependent increases to intramuscular carnosine concentrations with beta-alanine supplementation, with certain studies showing an increase of 40-60% with chronic administration. These same literatures reveal a synergistic effect of exercise on beta-alanine supplementation, whereby the muscle adaptive changes associated with resistance training promote further intramuscular carnosine production in response to beta-alanine supplementation.\u003c\/p\u003e\n\u003cp\u003eIn simpler language, this essentially means that beta-alanine is a dietary supplement that promotes its own effects in combination with exercise. As you exercise, you simultaneously intensify beta-alanine’s physiological actions – both directly, as well as in the production of intramuscular carnosine. Once ingested, beta-alanine’s exercise-specific beneficial activity is well-established. Elevation of intramuscular carnosine content via beta-alanine supplementation has been shown to improve performance in the following ways.\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eBoth acute and chronic increases in total work capacity, measured by total volume during exercise sessions.\u003c\/li\u003e\n\u003cli\u003eHighly significant increases to TTE (total time to exhaustion), one of the most accurate and comprehensive measures of endurance. In various trials, beta-alanine supplementation has been shown to increase TTE by upwards of 20%.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eIncreases to total muscle power output in both acute and chronic trials, suggesting that beta-alanine’s most significant benefit is to those engaging in power-dependent resistance training.\u003c\/p\u003e\n\u003cp\u003eIn total, a significant body of research exists to suggest that beta-alanine may significantly increase muscle power output, strength, training volume and output, overall performance in hypoxic (oxygen-deprived) conditions and peak VO2 max (oxygen holding capacity).\u003c\/p\u003e\n\u003cp\u003eThese myriad benefits make beta-alanine both one of the most-studied, and most well-rounded dietary supplements. Beta-alanine not only has direct, actionable physiological effects, but also promotes critical muscle physiologic adaptations that promote its own effects.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBetaine Anhydrous\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBetaine (trimethyl glycine) is found naturally in most living organisms. It is well known to protect non-mammalian animal life in conditions of osmotic stress (a rapid change in the amount of solute surrounding a cell), in addition to functioning as an osmolyte in mammalian (including human) tissues. Betaine is formed in cells as an oxidation product of choline and can be obtained in the diet from foods such as spinach and beets.\u003c\/p\u003e\n\u003cp\u003eThough data on betaine is limited, and recent, the available literature suggests that this compound may have effects in a few areas. Studies on betaine using servings as little as 1.25g\/day and up to 5g\/day for up to 14 days have shown promising results. In one study, a 2.5g\/day serving was found to enhance endurance and total repetition volume for the squat, bench press, and jump squat in in healthy-exercised trained adults. A similar study using the same serving found that betaine use increased peak power and maximum peak power, along with force and the maintenance of both force and power in healthy, exercise-trained subjects.\u003c\/p\u003e\n\u003cp\u003ePerhaps more interesting, however, is a study which examined betaine’s effect on the endocrine system. This study revealed that betaine may exert an effect on several endocrine processes given the proper conditions, causing the authors to hypothesize that long(er) term betaine supplementation may increase the hypertrophic response to resistance training.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eN-Acetyl L-Carnitine Hydrochloride\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eL-carnitine is a derivative of the amino acid lysine and, as certain conditions outpace the body’s ability to produce it, l-carnitine is considered a conditionally essential amino acid. While endogenous biosynthesis of l-carnitine from the amino acids lysine and methionine is sufficient for essential processes – along with dietary sources of carnitine from protein-rich red meat, for example – dietary supplementation of carnitine may pose benefits in certain physiological conditions.\u003c\/p\u003e\n\u003cp\u003eUnfortunately, due to excess metabolism of l-carnitine by microorganisms in the small intestine, exogenous supplementation with oral l-carnitine has proved ineffective. ALCAR, an acetylated version of l-carnitine, has considerably higher oral bioavailability, due likely to only partial hydrolytic metabolism. Once in the bloodstream, ALCAR plays a fundamental role in the production of energy, acting as the catalyst for the beta-oxidation of long chain fatty acids by the mitochondria; regulating the CoA to Acyl-CoA ratio (necessary to produce ATP); and the metabolism of carbohydrates. ALCAR also is an excitatory agent for neurons, increases neuronal transmission, and increases the production of neurotransmitters and neurohormones such as dopamine and serotonin.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAlpha GPC 50%\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eOf the known choline pro-drugs or precursors, Alpha GPC appears to have exert the greatest influence on circulating choline levels. Choline is an essential nutrient involved in numerous metabolic pathways, including DNA regulation and repair, protein function, and metabolism. Perhaps most importantly, the critical neurotransmitter acetylcholine is produced directly from free choline via cholinergic neurons. Acetylcholine is then responsible for several functions itself, most crucially as the compound which induces muscular contraction, and as the neuromodulator partially responsible for modulating risk\/reward, arousal, and enhancing memory.\u003c\/p\u003e\n\u003cp\u003eCholine’s essential role as a substrate for acetylcholine, and therefore brain development, is well documented in animal models. These studies demonstrate that levels of free maternal choline have a direct and fundamental impact on prenatal brain development, with the enhancements or deficits lasting into adulthood. Choline’s enhancing effect is particularly prominent in the hippocampus. In humans, the hippocampus is primarily involved in the consolidation of memory (taking short, episodic memory and translating it into long-term memory) and the learning of new information. Acetylcholine is a critical component in these processes, as mentioned above, and choline may therefore play a potential role in these processes as well by providing the substrate for acetylcholine synthesis.\u003c\/p\u003e\n\u003cp\u003eWhether through these, or other independent mechanisms, a recent trial using Alpha GPC demonstrated a statistically significant increase to power output. In a placebo-controlled, double-blind, randomized trial, 14 healthy volunteers, split into an Alpha GPC or placebo group, were tested on various exercises. In comparison to the placebo group, the Alpha GPC group experienced a 14% increase to bench press. The researchers hypothesize that the peak power increase was the result of a substantial acute increase to growth hormone, one of the observed effects of Alpha GPC supplementation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCaffeine Anhydrous\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCaffeine is one of the most widely consumed, and perhaps one of the most reviewed, psychoactive compounds. Its physiological effects in a range of areas have been well-documented, including exercise performance, information processing, alertness and mood enhancement, attention, and awareness, along with its anti-lipogenic and lipolytic abilities.\u003c\/p\u003e\n\u003cp\u003eMost importantly to Core PRE, caffeine has been shown to have significant effects on exercise performance, even with ingestion in servings as small 3 to 9mg\/kg\/bw\/day (the equivalent of 2 cups of standard coffee, for a 170lb male). In endurance training, possible explanations for caffeine’s performance-enhancing effects lie in its metabolic effects on both lean and fat tissue. It is suggested that caffeine’s potent lipolytic (the breakdown of fat tissue into fatty acids) and oxidative (the actual ‘burning’ of fat) action allow the body to utilize these sources during prolonged submaximal exercise. Consequently, muscle glycogen is spared and available for use later in the training session. Practically speaking, this means caffeine is forcing your body to preferentially use fat tissue as a fuel source, while sparing the glycogen which gives you the full-bodied look!\u003c\/p\u003e\n\u003cp\u003eIn short-term exercise, caffeine’s demonstrated role in the inhibition of cyclic AMP- phosphodiesterase’s (PDE), adenosine receptor antagonism, and adrenoreceptor agonism come into play. These three pathways collectively stimulate lipolytic activity, boost fat metabolism, increase metabolic rate and energy expenditure, and regulate the body’s thermogenic activity. The practical results of activating these pathways are increases to the contractile force of both cardiac and skeletal muscle (harder flexion), an increase in energy expenditure (freeing up more caloric energy to be used in contraction), dilation of vasculature (better blood flow), and improvements to both nitrogen retention and skeletal muscle protein synthesis (key components to muscle building).\u003c\/p\u003e\n\u003cp\u003eIn Core PRE, we have included a per-serving amount of caffeine that is neither excessive, nor arbitrary, but that instead reflects the servings used in clinical research.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAstraGin® (\u003ci\u003eAstragalus membranaceus\u003c\/i\u003e and \u003ci\u003ePanax notoginseng Root\u003c\/i\u003e Extracts)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAstraGin® is a trademarked combination of \u003ci\u003eAstragalus membranaceous\u003c\/i\u003e and \u003ci\u003ePanax notoginseng\u003c\/i\u003e that has been widely used in the supplement manufacturing industry largely for due to its clinically studied benefits for improving absorption of nutrients, peptides, and amino acids. Some statistics include increased absorption of creatine, leucine, citrulline, and other peptides by up to 67%, increased curcumin absorption by 92%, increases polyunsaturated fatty acids (from flax and fish oil) by 58% and 100% respectively, as well as can increase ATP production in the liver by 18%. AstraGin® has been shown capable of increasing muscle protein synthesis and increased mTOR through enhanced leucine absorption, which has an influence on improved glucose metabolism and mitochondrial functions. In addition to this benefit, AstraGin’s® ability to enhance polyunsaturated fatty acid absorption while also inhibiting saturated fatty acid absorption, thus reducing the risk of impaired glucose metabolism and mitochondrial function, can enhance ATP synthesis through mitochondrial respiration, and increase oxidative phosphorylation.\u003c\/p\u003e\n\u003cp\u003eIt has been further studied how \u003ci\u003eAstragalus\u003c\/i\u003e and \u003ci\u003ePanax notoginseng\u003c\/i\u003e specifically can protect mitochondria and enhance their function towards anti-aging. The proposed mechanism leads to \u003ci\u003eAstragalus\u003c\/i\u003e acting as a free radical scavenger, which can inhibit mitochondrial permeability transition and increase the activity of antioxidants against the peroxidation of membrane lipids. \u003ci\u003ePanax notoginseng\u003c\/i\u003e also works in a similar fashion through decreased free radical production. This lipid peroxidation has been shown to be a major cause of decreases in mitochondrial function. In addition to this, ensuring a highly permeable environment around the mitochondrial membrane is crucial for maintaining mitochondrial functions. This permeability allows for the passage of key electro chemicals to cross the gradient allowing for the process of energy development for the cells.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Orange_Cream_SFP_7713c606-a04b-48f2-8b9b-2939d9e793f4.png?v=1745614933\"\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Blue_Raspberry_SFP_25e3d89f-17d4-4b71-a582-172df389f6a1.png?v=1745614933\"\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Cherry_Berry_SFP_494e737a-d093-4189-861e-82ea855d8210.png?v=1745614933\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core-Pre-FunSweets-BlueRaspberry-15x3-FINAL_08c7c712-c0a8-4c7e-88e6-d8620b152c9b.pdf?v=1745612432\"\u003eFun Sweets® Blue Raspberry\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core-Pre-FunSweets-CherryBerry-15x3-FINAL_0d135861-879b-4bb4-a345-d3a5757348c5.pdf?v=1745612427\"\u003eFun Sweets® Cherry Berry\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core-Pre-FunSweets-OrangeCream-15x3-FINAL_4871bc60-df22-4371-b2db-2add9b196f73.pdf?v=1745612418\"\u003eFun Sweets® Orange Cream\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eIqbal, S., Klammer, N., \u0026amp; Ekmekcioglu, C. (2019). The Effect of Electrolytes on Blood Pressure: A Brief Summary of Meta-Analyses. Nutrients, 11(6), 1362. https:\/\/doi.org\/10.3390\/nu11061362\u003c\/p\u003e\n\u003cp\u003eShirreffs, S. M., \u0026amp; Sawka, M. N. (2011). Fluid and electrolyte needs for training, competition, and recovery. Journal of sports sciences, 29 Suppl 1, S39–S46. https:\/\/doi.org\/10.1080\/02640414.2011.614269\u003c\/p\u003e\n\u003cp\u003eAlonso R, Gibson CJ, Wurtman RJ, et al. Elevation of urinary catecholamines and their metabolites following tyrosine administration in humans. Biol Psychiatry 1982, 17:781-790. Lever M, Sizeland PC, Bason LM, Hayman CM, Chambers ST. Glycine betaine and proline betaine in human blood and urine. Biochim Biophys Acta1994;1200:259–64.\u003c\/p\u003e\n\u003cp\u003eSakura N, Ono H, Nomura S, Ueda H, Fujita N. Betaine dose and treatment intervals in therapy for homocystinuria due to 5, 10-methylenetetrahydrofolate reductase deficiency. J Inherit Metab Dis1998;21:84–5.\u003c\/p\u003e\n\u003cp\u003eVirtanen E, Junnila M, Soivio A. Effects of food containing betaine\/amino acid additive on the osmotic adaptation of young Atlantic salmon, Salmo salar L. Aquaculture 1989;83:109–22.\u003c\/p\u003e\n\u003cp\u003eBloomer RJ, Farney TM, Trepanowski JF, McCarthy CG, Canale RE. Effect of betaine supplementation on plasma nitrate\/nitrite in exercise-trained men. J Int Soc Sports Nutr. 2011 Mar 18;8:5.\u003c\/p\u003e\n\u003cp\u003eCraig SA. Betaine in human nutrition. Am J Clin Nutr. 2004; 80: 539–549.\u003c\/p\u003e\n\u003cp\u003eHoffman JR, Ratamess NA, Kang J, Rashti SL, Faigenbaum AD. Effect of betaine supplementation on power performance and fatigue. J Int Soc Sports Nutr. 2009 Feb 27;6:7.\u003c\/p\u003e\n\u003cp\u003eHoffman JR, Ratamess NA, Kang J, Gonzalez AM, Beller NA, Craig SA. Effect of 15 days of betaine ingestion on concentric and eccentric force outputs during isokinetic exercise. J Strength Cond Res. 2011 Aug;25(8):2235-41.\u003c\/p\u003e\n\u003cp\u003eLee EC, Maresh CM, Kraemer WJ, Yamamoto LM, Hatfield DL, Bailey BL, Armstrong LE, Volek JS, McDermott BP, Craig SA. Ergogenic effects of betaine supplementation on strength and power performance. J Int Soc Sports Nutr. 2010 Jul 19;7:27.\u003c\/p\u003e\n\u003cp\u003eOrtiz-Costa S, Sorenson MM, Sola-Penna M (2002) Counteracting effects of urea and methylamines in function and structure of skeletal muscle myosin. Arch Biochem Biophys 408:272–278\u003c\/p\u003e\n\u003cp\u003ePryor JL, Craig SA, Swensen T. Effect of betaine supplementation on cycling sprint performance. J Int Soc Sports Nutr. 2012 Apr 3;9(1):12.\u003c\/p\u003e\n\u003cp\u003eTrepanowski JF, Farney TM, McCarthy CG, Schilling BK, Craig SA, Bloomer RJ. The effects of chronic betaine supplementation on exercise performance, skeletal muscle oxygen saturation and associated biochemical parameters in resistance trained men. J Strength Cond Res. 2011 Dec;25(12):3461-71.\u003c\/p\u003e\n\u003cp\u003eUeland PM. Choline and betaine in health and disease. J Inherit Metab Dis. 2011;34:3–15.\u003c\/p\u003e\n\u003cp\u003eZeisel SH, Niculescu MD. Perinatal choline influences brain structure and function. Nutr Rev 2006;64:197–203.\u003c\/p\u003e\n\u003cp\u003eZeisel SH. The fetal origins of memory: the role of dietary choline in optimal brain development. J Pediatr 2006;149(suppl):S131–6.\u003c\/p\u003e\n\u003cp\u003eParnetti L, Amenta F, Gallai V. Choline alphoscerate in cognitive decline and in acute cerebrovascular disease: an analysis of published clinical data. Mech Ageing Dev. (2001)\u003c\/p\u003e\n\u003cp\u003eParnetti L, et al. Multicentre study of l-alpha-glyceryl-phosphorylcholine vs ST200 among patients with probable senile dementia of Alzheimer's type. Drugs Aging. (1993)\u003c\/p\u003e\n\u003cp\u003eBarbagallo Sangiorgi G, et al. alpha-Glycerophosphocholine in the mental recovery of cerebral ischemic attacks. An Italian multicenter clinical trial. Ann N Y Acad Sci. (1994) Alpha-GPC and power output; growth hormone.\u003c\/p\u003e\n\u003cp\u003eCeda GP, et al. alpha-Glycerylphosphorylcholine administration increases the GH responses to GHRH of young and elderly subjects. Horm Metab Res. (1992)\u003c\/p\u003e\n\u003cp\u003ePNAS, Sep 20 2005, 102(38):13681-13686. L-citrulline and L-arginine supplementation retards the progression of high-cholesterol-diet-induced atherosclerosis in rabbits.\u003c\/p\u003e\n\u003cp\u003eBr J Clin Pharma, 2008, 65:51-59 Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.\u003c\/p\u003e\n\u003cp\u003eUrology, Jan 2011, 77(1):119-22. Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction\u003c\/p\u003e\n\u003cp\u003eTangphao O, et al. Pharmacokinetics of intravenous and oral L-arginine in normal volunteers. Br J Clin Pharmacol. (1999).\u003c\/p\u003e\n\u003cp\u003eCuris E, Crenn P, Cynober L. Citrulline and the gut. Curr Opin Clin Nutr Metab Care. (2007).\u003c\/p\u003e\n\u003cp\u003eBahri S, et al. Mechanisms and kinetics of citrulline uptake in a model of human intestinal epithelial cells. Clin Nutr. (2008).\u003c\/p\u003e\n\u003cp\u003eTakeda K, et al. Effects of citrulline supplementation on fatigue and exercise performance in mice. J Nutr Sci Vitaminol (Tokyo). (2011)\u003c\/p\u003e\n\u003cp\u003eGiannesini B, et al. Citrulline malate supplementation increases muscle efficiency in rat skeletal muscle. Eur J Pharmacol. (2011).\u003c\/p\u003e\n\u003cp\u003eBendahan D, et al. Citrulline\/malate promotes aerobic energy production in human exercising muscle. Br J Sports Med. (2002).\u003c\/p\u003e\n\u003cp\u003ePérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res. (2010)\u003c\/p\u003e\n\u003cp\u003eLee, T., Wu, J., Jean, W. H., Condello, G., Alkhatib, A., Hsieh, C. C., Hsieh, Y. W., Huang, C. Y., \u0026amp; Kuo, C. H. (2021). Reduced stem cell aging in exercised human skeletal muscle is enhanced by ginsenoside Rg1. Aging, 13(12), 16567–16576. https:\/\/doi.org\/10.18632\/aging.203176\u003c\/p\u003e\n\u003cp\u003ePumpa KL, Fallon KE, Bensoussan A, Papalia S. The effects of Panax notoginseng on delayed onset muscle soreness and muscle damage in well-trained males: a double blind randomised controlled trial. Complement Ther Med. 2013 Jun;21(3):131-40.\u003c\/p\u003e\n\u003cp\u003eMartin-Rincon M, Morales-Alamo D, Calbet JAL. Exercise-mediated modulation of autophagy in skeletal muscle. Scand J Med Sci Sports. 2018 Mar;28(3):772-81.\u003c\/p\u003e\n\u003cp\u003eLiang MTC, Podolka TD, Chuang WJ. Panax notoginseng supplementation enhances physical performance during endurance exercise. J Strength Cond Res. 2005 Feb;19(1):108-14.\u003c\/p\u003e\n\u003cp\u003eLiu MH, Zhang Q, Zhang YH, Lu XY, Fu WM, He JY. Chemical analysis of dietary constituents in Rosa roxburghii and Rosa sterilis fruits. Molecules. 2016 Sep9;21(9):1204.\u003c\/p\u003e\n\u003cp\u003eKim DH. Chemical diversity of Panax ginseng, Panax quinquefolium, and Panax notoginseng. J Ginseng Res. 2012 Jan;36(1):1-15.\u003c\/p\u003e\n\u003cp\u003eKuo CH. Exercise against aging: Darwinian natural selection among fit and unfit cells inside human body. J Sci Sport Exerc. 2019 May;1(1):54-8.\u003c\/p\u003e\n\u003cp\u003eWeaver C. M. (2013). Potassium and health. Advances in nutrition (Bethesda, Md.), 4(3), 368S–77S. https:\/\/doi.org\/10.3945\/an.112.003533\u003c\/p\u003e\n\u003cp\u003eJeukendrup AE. Nutrition for endurance sports: marathon, triathlon, and road cycling. J Sports Sci. (2011)\u003c\/p\u003e\n\u003cp\u003eTraina G. (2016). The neurobiology of acetyl-L-carnitine. Frontiers in bioscience (Landmark edition), 21(7), 1314–1329. https:\/\/doi.org\/10.2741\/4459\u003c\/p\u003e\n\u003cp\u003eKarlic, H., \u0026amp; Lohninger, A. (2004). Supplementation of L-carnitine in athletes: does it make sense?. Nutrition (Burbank, Los Angeles County, Calif.), 20(7-8), 709–715. https:\/\/doi.org\/10.1016\/j.nut.2004.04.003\u003c\/p\u003e\n\u003cp\u003eKoozehchian, M. S., Daneshfar, A., Fallah, E., Agha-Alinejad, H., Samadi, M., Kaviani, M., Kaveh B, M., Jung, Y. P., Sablouei, M. H., Moradi, N., Earnest, C. P., Chandler, T. J., \u0026amp; Kreider, R. B. (2018). Effects of nine weeks L-Carnitine supplementation on exercise performance, anaerobic power, and exercise-induced oxidative stress in resistance-trained males. Journal of exercise nutrition \u0026amp; biochemistry, 22(4), 7–19. https:\/\/doi.org\/10.20463\/jenb.2018.0026\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Fun Sweets® Orange Cream","offer_id":53256720351542,"sku":"850057789591","price":161.9,"currency_code":"AED","in_stock":false},{"title":"Fun Sweets® Cherry Berry","offer_id":53256720384310,"sku":"850057789584","price":161.9,"currency_code":"AED","in_stock":false},{"title":"Fun Sweets® Blue Raspberry","offer_id":53256720417078,"sku":"850057789577","price":161.9,"currency_code":"AED","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/PRE_BR_Front_1.png?v=1762807419"},{"product_id":"pre","title":"Pre","description":"\u003cp\u003e\u003cstrong\u003eTHE ULTIMATE ESSENTIAL PRE-WORKOUT\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eMaximizes performance and endurance with clinically studied doses of L-Citrulline, Beta Alanine, and Betaine Anhydrous.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eCan enhance focus, energy, and mind-muscle connection through the powerful combination of Acetyl L-Carnitine, Alpha GPC, and Caffeine.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eImproves nutrient absorption and bioavailability with AstraGin® to unlock the full potential of every ingredient.\u003cbr\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003ciframe title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/mGhE9DoVeys?si=SPHtNsszjTfQv4ei\" height=\"315\" width=\"560\"\u003e\u003c\/iframe\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cmeta charset=\"utf-8\"\u003eCore PRE is the ultimate essential pre-workout designed to fuel your training every day with clinically dosed ingredients that support energy, endurance, and focus. With 200mg of caffeine, it delivers a clean, steady boost ideal for daily use. Added ingredients like L-Citrulline for nitric oxide and muscle pumps, beta-alanine to delay fatigue, and Alpha-GPC for sharper mind-muscle connection make Core PRE the perfect choice for consistent performance. No matter what event you’re training for, Core PRE keeps you dialed in, energized, and performing at your best.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMagnesium (as magnesium citrate), Sodium (as sodium citrate), Potassium (as potassium citrate)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cmeta charset=\"utf-8\"\u003eMagnesium, sodium, and potassium are key electrolytes critical for muscle contraction, hydration, nerve function, and energy production. Magnesium supports ATP synthesis and helps regulate calcium to reduce cramps and spasms. Sodium maintains fluid balance and nerve signaling, preventing dehydration and fatigue during intense training. Potassium works with sodium to keep muscles contracting properly, prevent cramps, and support glycogen storage for sustained energy. Together these minerals enhance performance, endurance, and recovery.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eL-Citrulline\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cmeta charset=\"utf-8\"\u003eL-Citrulline is a non-protein amino acid that efficiently converts to arginine, raising nitric oxide levels more effectively than arginine itself. This improves blood flow, reduces oxygen cost during exercise, and supports faster ATP and phosphocreatine replenishment. The result is better pumps, reduced fatigue, and improved endurance in both aerobic and anaerobic activity.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBeta Alanine\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cmeta charset=\"utf-8\"\u003eBeta-alanine raises carnosine levels in muscle, which buffers acidity and delays fatigue during high-intensity training. Research shows supplementation can increase time to exhaustion by up to 20 percent and boost total work capacity, power output, and endurance. The benefits are especially strong for explosive training, resistance work, and oxygen-deprived conditions, making beta-alanine one of the most proven and reliable performance supplements.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBetaine Anhydrous\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cmeta charset=\"utf-8\"\u003eBetaine, found naturally in foods like beets and spinach, functions as an osmolyte that supports cell hydration and power output. Studies show betaine can increase total reps, endurance, peak power, and force production. Some research also suggests long-term supplementation may boost the body’s anabolic response to training.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eN-Acetyl L-Carnitine Hydrochloride\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003e\u003cmeta charset=\"utf-8\"\u003eN-Acetyl L-Carnitine (ALCAR) is a highly bioavailable form of carnitine that fuels energy production by helping transport fatty acids into mitochondria, where they are burned for fuel. It also supports carbohydrate metabolism and neurotransmitter production, enhancing focus, mental energy, and recovery..\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAlpha GPC 50%\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cmeta charset=\"utf-8\"\u003eAlpha GPC is a choline compound that supports acetylcholine production, a neurotransmitter essential for muscular contractions and memory. Supplementation has been shown to increase strength and peak power, with one study reporting a 14 percent increase in bench press performance. Alpha GPC also promotes growth hormone release, making it effective for both mental and physical performance.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCaffeine Anhydrous\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cmeta charset=\"utf-8\"\u003eCaffeine is one of the most studied ergogenic aids, improving endurance, power, and alertness. It enhances fat metabolism, spares glycogen for later use, and increases muscle contractility. Even moderate doses improve training intensity, focus, and overall output. Core PRE includes a research-supported dose for clean energy without over-stimulation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAstraGin® (\u003ci\u003eAstragalus membranaceus\u003c\/i\u003e and \u003ci\u003ePanax notoginseng Root\u003c\/i\u003e Extracts)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cmeta charset=\"utf-8\"\u003eAstraGin, a patented blend of astragalus and Panax notoginseng, improves nutrient absorption and utilization. Research shows it can increase uptake of amino acids like leucine and citrulline, boost creatine absorption, and support glucose metabolism. 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This is, after all, the most studied, the most anecdotally verified, and the most well known dietary supplement available to us – and with good reason. The evidence on creatine truly does, “speak for itself.”\u003c\/p\u003e\n\u003cp\u003eWith that said, much hoopla has arisen over the past few years regarding how to take creatine, when to take creatine, which form is the best, and so on. 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As a dietary supplement, the use of creatine over extended periods of time has been linked to a wide-range of physiological benefits, including: cell volumization, increased delivery of plasma (blood) nutrients to the cell, an increase in skeletal muscle total mass and protein synthesis, decrease in muscular fatigue, and increased endurance.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Cherry_Berry_SFP.png?v=1743702350\"\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Blue_Raspberry_SFP.png?v=1743702350\"\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Orange_Cream_SFP.png?v=1743702350\"\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Lemon_Lime_SFP.png?v=1743702350\"\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Fruit_Punch_SFP.png?v=1743702350\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core-CreatineMono-Fruit_Punch-11x4.25-FINAL_Outlined.pdf?v=1743622504\"\u003eFruit Punch\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core-CreatineMono-LemonLime-11x4.25-FINAL_Outlined.pdf?v=1743622504\"\u003eLemon Lime\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core-FunSweets-BlueRaspberry-Creatine-11x4.25-FINAL_Outlined.pdf?v=1743622504\"\u003eFun Sweets® Blue Raspberry\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core-FunSweets-CherryBerry-Creatine-11x4.25-FINAL_Outlined.pdf?v=1743622504\"\u003eFun Sweets® Cherry Berry\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core-FunSweets-OrangeCream-Creatine-11x4.25-FINAL_Outlined.pdf?v=1743622496\"\u003eFun Sweets® Orange Cream\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"fruit-punch","offer_id":53256722186550,"sku":"850057789560","price":114.29,"currency_code":"AED","in_stock":true},{"title":"lemon-lime","offer_id":53256722219318,"sku":"850057789553","price":114.29,"currency_code":"AED","in_stock":true},{"title":"mystery-flavor","offer_id":53256722252086,"sku":"850057789966","price":114.29,"currency_code":"AED","in_stock":true},{"title":"fun-sweets-blue-raspberry","offer_id":53256722284854,"sku":"850057789522","price":114.29,"currency_code":"AED","in_stock":true},{"title":"fun-sweets-cherry-berry","offer_id":53256722317622,"sku":"850057789539","price":114.29,"currency_code":"AED","in_stock":true},{"title":"fun-sweets-orange-cream","offer_id":53256722350390,"sku":"850057789546","price":114.29,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/Creatine_FP_Front.png?v=1762807426"},{"product_id":"kidney","title":"Kidney","description":"\u003ch2 class=\"slogan\"\u003e\u003cb\u003e\u003cspan\u003eCOMPREHENSIVE KIDNEY SUPPORT'\u003c\/span\u003e\u003c\/b\u003e\u003c\/h2\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eGo-Less®\u003c\/strong\u003e: A blend of pumpkin seed extract and soy germ extract to promote healthy kidney and bladder function.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGoldenrod Extract: \u003c\/strong\u003e: Renowned for its diuretic, anti-inflammatory, and antimicrobial properties to support a healthy urinary system.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePaCran® Cranberry Extract\u003c\/strong\u003e: Helps protect against UTIs and encourages regular urinary flow.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eGo-Less®\u003c\/b\u003e is a clinically studied blend of pumpkin seed and soy germ extracts designed to support kidney and bladder health. It promotes bladder strength and flexibility, reduces urgency, and improves overall bladder function, making it especially beneficial for individuals with overactive bladder (OAB) symptoms. Clinical studies have shown that Go-Less® helps reduce urinary frequency and urgency, leading to improved bladder control and sleep quality. The supplement also supports kidney health by aiding in detoxification and helping the kidneys efficiently filter waste and excess fluids, lowering the risk of kidney-related issues.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eGoldenrod extract\u003c\/b\u003e, a versatile herb, is known for its diuretic, anti-inflammatory, and antimicrobial properties, which help maintain a healthy urinary system and manage conditions like UTIs and kidney stones. \u003cb\u003ePaCran® cranberry extract\u003c\/b\u003e, rich in flavonoids, provides protection against UTIs by preventing the adhesion of pathogens to the urinary tract, and also reduces inflammation and supports bladder function. Other ingredients like \u003cb\u003eStinging Nettle\u003c\/b\u003e, \u003cb\u003eGrape Seed\u003c\/b\u003e, and \u003cb\u003eAstragalus extracts\u003c\/b\u003e further support kidney and bladder health by promoting healthy urine flow, reducing oxidative stress, and enhancing immune function, making this supplement an effective, natural solution for maintaining urinary health.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eGo-Less® Proprietary Blend [Pumpkin (\u003ci\u003eCurcurbita pepo\u003c\/i\u003e) Seed Extract, Soy (Glycine max) Germ Extract]\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eGo-Less® is a clinically studied blend of pumpkin seed extract and soy germ extract, that has been specifically formulated to support the health and function of the kidneys and bladder. As a natural supplement, Go-Less® can offer an effective approach to managing urinary tract health, reducing time for bladder emptying, and improving overall quality of life.\u003c\/p\u003e\n\u003cp\u003eTo promote healthy and normal bladder function, the unique combination of pumpkin seed and soy germ extracts found in Go-Less® can work synergistically to support bladder strength and flexibility. Pumpkin seed extract is rich in essential fatty acids and phytosterols, which have been shown to improve bladder function by enhancing the tone of the bladder muscles and supporting the integrity of the bladder wall. This can help reduce the sensation of urgency and the frequency of urination, making it especially beneficial for individuals dealing with overactive bladder (OAB) symptoms.\u003c\/p\u003e\n\u003cp\u003eClinical studies have demonstrated the effectiveness of Go-Less® in improving bladder health. One study published in \u003ci\u003eUrology\u003c\/i\u003e found that participants who took Go-Less® experienced a significant reduction in daytime and nighttime urinary frequency, as well as a decrease in urgency episodes. This improvement in bladder control was attributed to the supplement’s ability to strengthen the bladder muscles and reduce bladder pressure, leading to fewer interruptions in daily activities and better sleep quality at night.\u003c\/p\u003e\n\u003cp\u003eGo-Less® also has been shown to provide support for kidney health, an essential aspect of maintaining overall urinary system function. The kidneys play a critical role in filtering waste and excess fluids from the blood, and their proper function is vital for maintaining electrolyte balance and blood pressure. The natural compounds in Go-Less® can help support the kidneys’ detoxification processes, ensuring they operate efficiently and reducing the risk of developing kidney-related issues.\u003c\/p\u003e\n\u003cp\u003eIn addition to its direct benefits for bladder and kidney health, Go-Less® also offers a natural alternative for those seeking to manage urinary health without the side effects associated with pharmaceutical options. The ingredients in Go-Less® are 100% plant-based and have shown to be well-tolerated by users, making it a safe option for long-term use in those who are affected by bladder and kidney related issues. This is particularly important for individuals with chronic urinary issues or those looking to maintain their urinary health as they age.\u003c\/p\u003e\n\u003cp\u003eAs the backbone in our KIDNEY Lifeline product, Go-Less® can provide comprehensive support for kidney and bladder health through a combination of clinically proven ingredients. By promoting bladder strength, reducing urinary frequency, and supporting kidney function, Go-Less® offers a natural and effective solution for individuals seeking to improve their urinary health and enhance their overall quality of life. So, whether you're looking to manage the symptoms of an overactive bladder or simply looking to maintain healthy kidney function, Go-Less® is a trusted option backed by clinical research to support its benefits.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eGoldenrod Extract 10:1 (\u003ci\u003eSolidago decurrens Lour\u003c\/i\u003e) (Whole Plant)\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eGoldenrod (\u003ci\u003eSolidago virgaurea\u003c\/i\u003e) is a versatile herb that has been used for centuries in traditional medicine to support kidney and bladder health. Most notably used for its diuretic, anti-inflammatory, and antimicrobial properties, Goldenrod can be a suitable choice for those looking to maintain a healthy urinary system and manage conditions such as urinary tract infections (UTIs) and kidney stones.\u003c\/p\u003e\n\u003cp\u003eOne of the primary benefits of Goldenrod is its diuretic effect, which promotes healthy urine flow and can help flush out toxins and other waste products from the kidneys. This increased urine output can be particularly beneficial for preventing the formation of kidney stones by reducing the concentration of minerals and salts in the urine that can lead to stone formation.\u003c\/p\u003e\n\u003cp\u003eIn addition to its diuretic properties, Goldenrod is known for its anti-inflammatory and antimicrobial effects, which can help manage and prevent urinary tract infections (UTIs). UTIs are often caused by bacteria that find a home within the urinary tract, leading to discomfort, pain, and frequent urination. Goldenrod contains compounds such as saponins and flavonoids, which have been shown to inhibit the growth of harmful bacteria and reduce inflammation in the urinary tract. Several studies have demonstrated that Goldenrod extract exhibits strong antimicrobial activity against common UTI-causing bacteria, such as \u003ci\u003eE. coli\u003c\/i\u003e, and other harmful bacteria. By combating bacterial growth and soothing inflammation, Goldenrod can aid in the alleviation of UTI symptoms and support the body's natural defenses against infection.\u003c\/p\u003e\n\u003cp\u003eGoldenrod can also offer support for overall bladder health, particularly in managing conditions like overactive bladder (OAB) and bladder inflammation. Again, its anti-inflammatory properties can help reduce irritation in the bladder, while its diuretic action can ensure that the bladder is regularly flushed, preventing the buildup of irritants that can trigger OAB symptoms. Goldenrod’s ability to strengthen and tone the urinary tract muscles can contribute to better bladder control, reducing the frequency and urgency of urination.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003ePaCran® Cranberry Extract\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eCranberry (\u003ci\u003eVaccinium macrocarpon\u003c\/i\u003e), a rich and distinctive source of flavonoids and phenolic acids, has been often utilized to protect against urinary tract infections (UTIs), the second most common type of infection worldwide. These infections, as we have discovered above, are often triggered from the exposure of unwanted bacterium, most notably \u003ci\u003eE. coli\u003c\/i\u003e, and can lead to significant issues that not only affect internal organs, but also can negatively affect overall quality of life. Cranberry’s being rich is flavonoids, particularly proanthocyanidins, anthocyanidins, and flavanols, along with other phenolic acids and benzoates, provide some key mechanisms of action for their protective effects. These flavonoids have been shown to act as antiadhesive agents in preventing\/inhibiting the adherence of pathogens to uroepithelial cell receptors, which appear to be a major component in the pathogenesis of UTIs.\u003c\/p\u003e\n\u003cp\u003ePaCran® is a clinically studied cranberry extract specifically designed to support overall kidney and bladder health. Unlike other traditional cranberry products, PaCran® combines the full spectrum of cranberry's beneficial compounds mentioned above, which are known for their ability to promote healthy urinary tract function and aid in the prevention of infection. One study looking at the effects of cranberry ingestion on urinary health demonstrated that women who supplemented with a cranberry extract rich in PACs experienced a significant reduction in the recurrence of UTIs. This data suggests that PaCran® can be an effective preventive measure for those prone to recurrent UTIs.\u003c\/p\u003e\n\u003cp\u003eIn addition to its role in preventing infections, PaCran® also supports overall bladder health by reducing inflammation and promoting regular urinary flow. The anti-inflammatory properties of cranberry help soothe the urinary tract, reducing irritation and discomfort that can be caused by infections or other urinary conditions. By promoting healthy bladder function, PaCran® can help to maintain a comfortable and efficient urinary flow, reducing the frequency and urgency of urination often associated with bladder irritation or overactive bladder (OAB).\u003c\/p\u003e\n\u003cp\u003ePaCran® also can offer benefits for kidney health. The potent antioxidant properties of PaCran® can help protect the kidneys from high amounts of oxidative stress, which can lead to cellular damage and impair kidney function over time. By neutralizing free radicals, PaCran® can support the kidneys' ability to efficiently filter and eliminate toxins, contributing to long-term kidney health.\u003c\/p\u003e\n\u003cp\u003eBacked by several human clinical studies, PaCran® is a natural and well-tolerated supplement, making it a safe option for long-term use in maintaining urinary health. It offers a more convenient and concentrated form of cranberry's benefits without the high sugar content often found in cranberry juice, making it an ideal choice for individuals looking to manage their urinary health naturally and effectively.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eStinging Nettle Extract (\u003ci\u003eUrtica dioica\u003c\/i\u003e) (Root) (20:1)\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eStinging nettle has been widely used in traditional medicine for its benefits as a diuretic and to treat things like joint pain, eczema, arthritis, gout, and anemia. More recently, stinging nettle has been utilized for the purpose of maintaining normal urinary flow and contributing to a healthy, optimal functioning prostate. Stinging nettle has also shown effectiveness when used in combination with other herbs, like saw palmetto (included above). Human studies have shown this effectiveness in these areas, like urinary flow maintenance, through their specific mechanisms of action, which were discussed in the paragraph above.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eGrape Seed Extract (\u003ci\u003eVitis vinifera\u003c\/i\u003e) (Seed) (Std. to 95% Proanthocyanidins)\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eGrape seed extract, a powerful, antioxidant rich compound derived from the seeds of grapes, often utilized for it benefits for cardiovascular health, also has been shown to offer significant benefit for the kidneys and bladder. Primarily through its ability to combat oxidative stress, reduce inflammation, and promote overall urinary tract function, grape seed extract can be a beneficial compound to support these areas.\u003c\/p\u003e\n\u003cp\u003eGrape seed extracts primary benefits for kidney health lies in its potent antioxidant properties. The kidneys are constantly exposed to oxidative stress as they filter toxins and waste products from the blood. Over time, this exposure can lead to cellular damage, contributing to the development of chronic kidney disease (CKD) and other kidney-related issues. The proanthocyanidins found in grape seed extract have been shown to neutralize free radicals and protect kidney cells from excessive oxidative damage.\u003c\/p\u003e\n\u003cp\u003eIn addition to its antioxidant effects, grape seed extract also has inflammatory mitigating properties that benefit both the kidneys and bladder. Chronic inflammation is a common factor in many urinary tract issues, including interstitial cystitis (IC) and other forms of bladder irritation. Grape seed extract has been shown to reduce inflammation by inhibiting the production of pro-inflammatory cytokines and enzymes, such as COX-2.\u003c\/p\u003e\n\u003cp\u003eGrape seed extract may also play a role in protecting against urinary tract infections (UTIs). The antimicrobial properties of grape seed extract, combined with its ability to strengthen the bladder lining, can help create an environment that is less favorable for bacterial growth.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eAstragalus Extract (\u003ci\u003eAstragalus membranaceous\u003c\/i\u003e) (Root) (Std. to 50% Polysaccharides)\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eAstragalus extract (\u003ci\u003eAstragalus membranaceous\u003c\/i\u003e) has been shown to offer powerful benefits for overall urinary system health. Polysaccharides, the active compounds in Astragalus, are known for their immune-boosting, anti-inflammatory, and potent antioxidant properties.\u003c\/p\u003e\n\u003cp\u003eOne of the primary benefits of Astragalus extract for kidney health is its ability to protect against renal damage and support kidney function. The polysaccharides contained within Astragalus have been shown to reduce proteinuria, which is the presence of excess protein in the urine. This can be a common sign of kidney damage, particularly in conditions like chronic kidney disease (CKD).\u003c\/p\u003e\n\u003cp\u003eThe antioxidant properties of Astragalus polysaccharides can further enhance kidney protection by combating oxidative stress, which is a major contributor to kidney damage.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eSetria® Glutathione\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eGlutathione is an amino acid containing molecules of L-glutamic acid, L-cysteine, and Glycine that is particularly concentrated in the liver. The liver has a unique ability to synthesize cysteine, a glutathione precursor, from endogenous sources through the trans-sulphuration pathway or through protein breakdown and food. It is vital to many different properties and is best known for being a powerful antioxidant.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eAstraGin® (\u003ci\u003eAstragalus membranaceus\u003c\/i\u003e and \u003ci\u003ePanax notoginseng\u003c\/i\u003e Root Extracts)\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eAstraGin® is a patented blend of natural extracts derived from \u003ci\u003eAstragalus membranaceus\u003c\/i\u003e and \u003ci\u003ePanax notoginseng\u003c\/i\u003e. While it is most widely recognized and utilized for its role in enhancing nutrient absorption, AstraGin® can also offer significant benefits for overall kidney and bladder health.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eBioPerine® (\u003ci\u003ePiper nigrum\u003c\/i\u003e) (Fruit) (Std. to 95% piperine)\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eBioPerine® is a patented standardized extract from the fruit of \u003ci\u003ePiper nigrum\u003c\/i\u003e (black pepper). It’s studied benefits have shown improvements in bioavailability of nutrients it is surrounded by.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg alt=\"\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Kidney_Banner.jpg?v=1738276352\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Lifeline-Kidney-8.5x3.25-FINAL_Outlined.png?v=1738280725\"\u003eUnflavored Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eREFERENCES\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eBongseok Shim, Hyewon Jeong, Sara Lee, Sehee Hwang, Byeongseok Moon, Charlotte Storni, A randomized double-blind placebo-controlled clinical trial of a product containing pumpkin seed extract and soy germ extract to improve overactive bladder-related voiding dysfunction and quality of life, Journal of Functional Foods, Volume 8, 2014, Pages 111-117, ISSN 1756-4646, \u003ca href=\"https:\/\/doi.org\/10.1016\/j.jff.2014.03.010\"\u003ehttps:\/\/doi.org\/10.1016\/j.jff.2014.03.010\u003c\/a\u003e.\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":53256725201206,"sku":"850057789355","price":247.62,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/KIDNEYFRONT_b42418a1-aa5b-4758-b31a-b9a7e0af7b8c.png?v=1762807439"},{"product_id":"iceshaker","title":"26oz Crush It Ice Shaker","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e26oz. Official Insulated Ice\u003c\/li\u003e\n\u003cli\u003ePatented, noise-free twist-on agitator\u003c\/li\u003e\n\u003cli\u003eMeasurement markings inside bottle\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eCarrying Handle\u003c\/li\u003e\n\u003cli\u003eFits All Standard Size Cup Holders\u003c\/li\u003e\n\u003cli\u003eSilicon Base\u003c\/li\u003e\n\u003cli\u003eEasy To Clean\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Navy","offer_id":53256725889334,"sku":"Core-Arnold-Shaker-Navy","price":39.99,"currency_code":"AED","in_stock":false},{"title":"Black","offer_id":53256725922102,"sku":"Core-Arnold-Shaker-Black","price":39.99,"currency_code":"AED","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/IceShaker_0006_Navy.png?v=1762807442"},{"product_id":"transformers-protron","title":"Transformers® Protron Advanced Muscle Builder Formula","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eWhey + Casein Blend\u003c\/strong\u003e\u003cbr\u003eSustained release for optimal recovery and growth.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdded MCTs\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eHealthy source of fats as well as adds to creamy texture.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDigestive Enzymes\u003c\/strong\u003e\u003cbr\u003e\u003cmeta charset=\"utf-8\"\u003e \u003cspan\u003eSupports healthy nutrient breakdown.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp class=\"p1\"\u003eThe \u003cb\u003ePROTRON\u003c\/b\u003e supplement is emblematic of the strength and resilience of the TRANSFORMERS\u003cspan class=\"s1\"\u003e\u003csup\u003e®\u003c\/sup\u003e\u003c\/span\u003e robots, offering a high-powered protein blend that's as strong and versatile as the characters themselves. With a delicious flavor and formula designed to support muscle growth and recovery, PROTRON can help you build and maintain your power.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eProtein powders need to – or at least should – have a purpose: to improve recovery times, and ultimately, body composition. But how does that occur? Or more specifically, what needs to happen in the body to recover from a workout, and subsequently improve body composition. To sum it up with one phrase, net protein balance needs to be positive.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eWhen you vigorously train or exert yourself, a process called protein degradation (the breakdown of muscle protein) begins so that the body can fuel itself, and a process called muscle protein synthesis (the creation of muscle protein) slows down. Think of this like shutting off your engine (protein synthesis), to fuel your car (muscle protein breakdown). As this entire process plays out, the available pool of amino acids in skeletal muscle depletes, as they too are drawn in and broken down in the natural, catabolic process during exercise training.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eWhile this situation is quite adequate during a training session, it’s precisely the opposite of what we want afterwards. At that point, we want the available pool of amino acids to increase, protein degradation to slow or stop, and muscle protein synthesis to increase. Enter protein supplements. Protein powders are a quick, convenient way to rapidly increase the available pool of amino acids in skeletal muscle.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eHowever, not all proteins are created equal when assessed within the matrix of molecular triggers, enzymes, and amino acids that constitute skeletal muscle protein synthesis. Low quality blends, fillers, masking agents, and the like reduce the net protein content of many protein products, ultimately reducing lean muscle impact.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eA quality protein supplement not only contains a high amount of protein, but the protein sources from which it draws need to be themselves high quality – and the benefit a particular protein source has can be assessed by analyzing its amino acid profile. Human skeletal muscle makes the most use out of a few amino acids (the BCAAs among them), and so a quality protein needs to have an amino acid profile that is optimal for this context.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eWe chose the protein blend for PROTRON with optimization in mind. Our mix of cold-processed undenatured whey protein concentrate, crossflow microfiltered whey protein isolate, and milk protein isolate has a complete amino acid profile that has been shown in research to increase nitrogen retention, lean muscle impact, and satiating ability (the feeling of fullness). This blend has also been specifically configured to provide both rapid \u003ci\u003eand\u003c\/i\u003e sustained additions to your body’s amino acid profile – meaning your recovery is not only supported immediately after a session, when you most need it, but over time as well.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eBest of all, we have a \u003ci\u003efully transparent \u003c\/i\u003elabel for PROTRON. Meaning that not only do we disclose the protein sources themselves and their specific yields, but we have also disclosed the entire formula’s amino acid profile. You can see, for example, that each serving yields a full 2.6g of leucine – a leucine dose supported in the literature to maximally increase muscle protein synthesis.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eHere is a more complete breakdown of each protein source:\u003c\/p\u003e\n\u003cp class=\"p3\"\u003e\u003cb\u003eCold-processed undenatured whey protein concentrate\u003c\/b\u003e: Whey protein concentrate is probably the most common form of whey protein you will find. However, how it is processed is where the benefit truly lies. This process of cold processed undenaturization preserves the molecular structure of the amino acid particles as well as the immune boosting benefits that it contains. This undenatured protein is also a rich source of amino acids, including those needed for the synthesis of glutathione, which is an important antioxidant that can be depleted by stress (exercise stress included). This makes it a great foundation for your post workout recovery nutrition.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003e\u003cb\u003eCrossflow microfiltered whey protein isolate:\u003c\/b\u003e \u003cbr\u003eWhey protein isolate is an extremely “clean” form of whey protein. It yields a higher number of amino acids, half of which are from the essential amino acids (cannot be made by the body). Microfiltration eliminates a large majority of the fat and lactose from the whey, which makes it easily digestible and quickly absorbed into the body. This crossflow process uses a highly intricate method to isolate the protein. It is not subjected to chemicals and is thus left in its most natural state.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003e\u003cb\u003eMilk Protein Isolate:\u003c\/b\u003e \u003cbr\u003eMilk protein isolate is obtained through the partial removal of non-protein materials from skim milk (lactose and other minerals). What you are left with is a dry product that contains more than 90% protein by weight. This product contains both casein and whey proteins in their original proportions found in milk, without combining separately produced casein and whey proteins. It contains very little fat and lactose and has a very high amino acid composition making it a perfect addition to this blend.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eThis blend has also been specifically configured to provide both rapid and sustained additions to your body’s amino acid profile – meaning your recovery is not only supported immediately after a session but will also carry you to your next meal. On top of that, our flavors are out of this world! We’ve also boosted this protein blend with digestive enzymes that will provide you with all the confidence that those nutrients you just supplied your body with will do their part in your quest for the optimal result!\u003c\/p\u003e\n\u003cp class=\"p3\"\u003e\u003cspan class=\"s2\"\u003e\u003cb\u003eDigeSEB\u003c\/b\u003e\u003c\/span\u003e\u003cspan class=\"s3\"\u003e\u003cb\u003e\u003csup\u003e®\u003c\/sup\u003e\u003c\/b\u003e\u003c\/span\u003e\u003cspan class=\"s2\"\u003e\u003cb\u003e Digestive enzyme blend:\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eOne can easily make the argument that dietary enzymes – and digestive enzymes – are the most consistently underrated and overlooked component to a supplementation regimen. These powerful little protein structures influence or outright control a vast, complex network of bodily functions. In a fitness-specific context, digestive enzymes play a crucial role in the breaking down of dietary carbohydrates, fats, and proteins into their constitutive parts, and therefore allow your body to use them in various processes (glycogenesis, protein synthesis, etc.).\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eDespite their critical function, many supplement companies overlook the necessity of digestive enzymes and do not include sufficient levels (and kinds) of enzymes in their products. For a whey product, in particular – a compound that requires \u003ci\u003esignificant \u003c\/i\u003edigestion and breakdown – this is madness.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eAs usual, we take a much more comprehensive, clinical approach than the average. In the PROTRON supplement, we have included a digestive enzyme blend called DigeSEB\u003cspan class=\"s1\"\u003e\u003csup\u003e®\u003c\/sup\u003e\u003c\/span\u003e comprised of amylases, proteases, lactases, amylases, and cellulases, allowing for a full and complete breakdown of all PROTRON’s components. Research suggests that whey absorption through the blood is heavily impacted by its gastric digestibility. Using DigeSEB\u003cspan class=\"s1\"\u003e\u003csup\u003e®\u003c\/sup\u003e\u003c\/span\u003e ensures that the protein – along with its milk and whey sugars and fats – are completely broken down.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eDigeSEB\u003cspan class=\"s1\"\u003e\u003csup\u003e®\u003c\/sup\u003e\u003c\/span\u003e ensures that the PROTRON supplement not only provides gourmet taste and clinical ingredients within the protein itself, but that your protein also increases the effectiveness of your pre- and post-workout nutrition in general.\u003c\/p\u003e\n\u003cp class=\"p5\"\u003e\u003cspan class=\"s2\"\u003e\u003cb\u003eCoconut Oil Creamer (Medium Chain Triglycerides):\u003cbr\u003e\u003c\/b\u003e\u003c\/span\u003eCoconut oil made of 100% Medium chain triglycerides has been shown to have the greatest health benefits. MCTs are made up of a chemical structure that allows them to quickly and effectively bypass gastric uptake for transport directly to the liver for oxidation and then used for energy. Their unusual chemical structure and metabolic process has resulted in MCTs being a focus for a wide range of therapeutic and exercise supplement uses.\u003c\/p\u003e\n\u003cp class=\"p5\"\u003eIn the context of exercise science, recent research has shown that MCTs significantly (up to 65%) increase resting energy expenditure, along with dose-dependently reducing fatty acid deposition in adipose tissue. These results suggest that MCTs are effectively increasing the body’s metabolic response to food intake.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/TF-Protron-MixedBerryCheesecake-17x4.75.pdf?v=1726132935\"\u003eMixed Berry Cheesecake Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/TF-Protron-PBCookiesNCream-17x4.75.pdf?v=1726133568\"\u003ePB Cookies 'N Cream Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/TF-Protron-VanillaHoneyGraham-17x4.75.pdf?v=1726133292\"\u003eVanilla Honey Graham Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003ch3 class=\"p7\"\u003e\u003cspan class=\"s2\"\u003e\u003cb\u003eReferences:\u003c\/b\u003e\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"p7\"\u003e\u003cspan class=\"s2\"\u003e\u003cb\u003e\u003cbr\u003e\u003c\/b\u003e\u003c\/span\u003eBabayan, V. K. (1987) Medium-chain triglycerides and structured lipids. Lipids 22:417-420.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eBach, A. C. \u0026amp; Babayan, V. K. (1982) Medium-chain triglycerides: an update. Am. J. Clin. Nutr. 36:950-962.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eScalfi, L, Coltorti, A. \u0026amp; Contaldo, F. (1991) Postprandial thermogenesis in lean and obese subjects after meals supplemented with medium-chain and long-chain triglycerides. Am. J. Clin. Nutr. 53:1130-1133.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eSeaton, T. B., Welle, S. L, Warenko, M. K. \u0026amp; Campbell, R. G. (1986) Thermic effect of medium-chain and long-chain triglycerides in man. Am. J. Clin. Nutr. 44:630-634.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eDulloo, A. G., Fathi, M., Mensi, N. \u0026amp; Girardier, L. (1996) Twenty-four-hour energy expenditure and urinary catecholamines of humans consuming low-to-moderate amounts of medium-chain triglycerides: a dose-response study in human respiratory chamber. Eur. J. Clin. Nutr. 50:152-155.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eFlatt, J. P., Ravussin, E., Acheson, K. J. \u0026amp; Jequier, E. (1985) Effects of dietary fat on postprandial substrate oxidation and on carbohydrate and fat balances. J. Clin. Investig. 76:1019-1024.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eHill, J. O., Peters, J. C., Yang, D., Sharp, T., Kaler, M., Abumrad, N. N. \u0026amp; Greene, H. L. (1989) Thermogenesis in humans during overfeeding with medium-chain triglycerides. Metabolism 38:641-648\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eWhite, M. D., Papamandjaris, A. A. \u0026amp; Jones, P.J.H. (1999) Enhanced postprandial energy expenditure with medium-chain fatty acid feeding is attenuated after 14 d in premenopausal women. Am. J. Clin. Nutr. 69:883-889.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eAstbury NM, et al. Dose-response effect of a whey protein preload on within-day energy intake in lean subjects. Br J Nutr. (2010)\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eFrestedt JL, et al. A whey-protein supplement increases fat loss and spares lean muscle in obese subjects: a randomized human clinical study. Nutr Metab (Lond). (2008)\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eZhu K, et al. The effects of a two-year randomized, controlled trial of whey protein supplementation on bone structure, IGF-1, and urinary calcium excretion in older postmenopausal women. J Bone Miner Res. (2011)\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eRennie MJ, et al. Control of the size of the human muscle mass. Annu Rev Physiol. (2004)\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eAnabolic signalling deficits underlie amino acid resistance of wasting, aging muscle\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eNutrient signalling in the regulation of human muscle protein synthesis\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eLeucine supplementation improves muscle protein synthesis in elderly men independently of hyperaminoacidaemia\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eTang JE, et al. Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men. J Appl Physiol. (2009)\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eWhey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older men\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eDangin M, et al. The digestion rate of protein is an independent regulating factor of postprandial protein retention. Am J Physiol Endocrinol Metab. (2001)\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eEngelen MP, et al. Casein protein results in higher prandial and exercise induced whole body protein anabolism than whey protein in Chronic Obstructive Pulmonary Disease. Metabolism. (2012)\u003c\/p\u003e\n\u003cp class=\"p3\"\u003ePal S, Ellis V, Dhaliwal S. Effects of whey protein isolate on body composition, lipids, insulin and glucose in overweight and obese individuals. Br J Nutr. (2010)\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eHaraguchi FK, et al. Evaluation of biological and biochemical quality of whey protein. J Med Food. (2010)\u003c\/p\u003e\n\u003cp class=\"p3\"\u003ede Aguilar-Nascimento JE, Prado Silveira BR, Dock-Nascimento DB. Early enteral nutrition with whey protein or casein in elderly patients with acute ischemic stroke: a double-blind randomized trial. Nutrition. (2011)\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eCandow DG, et al. Effect of whey and soy protein supplementation combined with resistance training in young adults. Int J Sport Nutr Exerc Metab. (2006)\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Milk Chocolate Cookies 'n Cream (Starscream)","offer_id":53256727068982,"sku":"850057789645","price":228.57,"currency_code":"AED","in_stock":true},{"title":"Mixed Berry Cheesecake (Optimus Prime)","offer_id":53256727101750,"sku":"850057789447","price":228.57,"currency_code":"AED","in_stock":true},{"title":"PB Cookies 'N Cream (Megatron)","offer_id":53256727134518,"sku":"850057789461","price":228.57,"currency_code":"AED","in_stock":true},{"title":"Vanilla Honey Graham (Bumblebee)","offer_id":53256727167286,"sku":"850057789454","price":228.57,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/PROTRON_MILKCHOCOLATE_FRONT_9df3aeaf-4ae7-4477-a5e5-9362dc64bf7b.png?v=1762807448"},{"product_id":"transformers-allspark","title":"Transformers® Allspark EAA Hydration \u0026 Recovery Supplement","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eFull Blend of Electrolytes\u003c\/strong\u003e - Can replace key electrolytes lost during intense training.*\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFull Serving of EAAs\u003c\/strong\u003e - Can Support recovery and muscle protein synthesis.*\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eElevATP®\u003c\/strong\u003e - Can increase levels of endogenous ATP.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eVitamin C (as ascorbic acid)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eVitamin C is historically best-known for the treatment and prevention of scurvy, though it has many other roles in the body. For example, vitamin C catalyzes or is a cofactor in eight enzymatic reactions involved in the synthesis of collagen, the nutrient carnitine, and several neurotransmitters necessary for the proper function of the brain.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIn the contemporary context, vitamin C is best known as a potent antioxidant. In addition to its intrinsic activity as an antioxidant, vitamin C has been shown in in vitro trials to regenerate alpha-tocopherol (vitamin E). As an antioxidant, vitamin C combats the detrimental effects of a group of compounds called radical oxygen species that, when produced, degrade the lipid membrane of the cell and may cause internal damage. By “scavenging” these free radicals, vitamin C and other antioxidants form a defense against excess cellular damage.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eCalcium (as calcium carbonate, calcium citrate, dicalcium malate (DimaCal®)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWhile best-known as the main bioactive in milk, and a compound that contributes to strong bones, calcium has numerous physiological effects in the body. As a key electrolyte it is responsible for mediating vascular contraction and vasodilatation, muscle function, nerve transmission, intracellular signaling, and hormonal secretion. Homeostatic regulation of calcium, which the body cannot produce, also requires sufficient levels of vitamin D. In the context of muscular contraction and relaxation, if calcium is required for strong contractions, magnesium is required for efficient relaxation of those muscle fibers.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eDimaCal®\u003cstrong\u003e \u003c\/strong\u003eis a trademarked form of dicalcium malate, which is calcium bonded with malic acid. It has been shown in studies to be a much better absorbed form of calcium and can maintain serum calcium levels for a much longer period. This can lead to a better maintained electrolyte level and greater performance where calcium is required.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eMagnesium (as magnesium carbonate, magnesium citrate, magnesium bisglycinate chelate, magnesium chloride, magnesium lysinate glycinate chelate)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eMagnesium, an often-overlooked electrolyte, is the second most abundant intracellular cation (after potassium). It is a cofactor to over three hundred enzymatic reactions in the body and is required for cellular energy metabolism, functioning of the sodium\/potassium adenosine triphosphatase pump, nerve conduction, and ion transport. Magnesium is also required for the use of the body’s energy currency, ATP. To become biologically active, ATP must be bound to magnesium to form Mg-ATP. In addition, magnesium is necessary for the proper function of cells with calcium and potassium gated ion channels such as heart and muscle cells. Working alongside calcium, magnesium plays a crucial role in the body by regulating muscular contractions as well as cramp prevention. In the context of muscle health and rehydration, the longer and more intense a bout of physical activity is, the more magnesium is lost primarily through sweat and urine. This loss of electrolyte balance requires its replenishment so that physical performance can remain at its peak throughout the duration of the activity reducing the risk of injury or bodily harm. Regardless of the type of sport or exercise, muscular contractions and energy production could not occur consistently without the presence of magnesium.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eZinc (as zinc bisglycinate chelate)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eAs an essential mineral, like magnesium, zinc is also involved in a wide range of essential biological functions in the human body – and a requirement in the catalytic activity of over one hundred enzymes.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eMost notably, zinc is vital for immune function, protein synthesis, cellular division, and DNA synthesis. For immune function, zinc is required for the function of a group of immune cells known as neutrophils and macrophages, which eliminate pathological cells and their products from the body.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWith magnesium, sufficient levels of zinc are also necessary for the production and maintenance of healthy levels of testosterone.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eChloride (as magnesium chloride)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eChloride is one of the most important electrolytes in the human body. Like sodium and potassium, which will be discussed below, chloride creates specific channels in cell membranes which help to carry out different vital tasks. It is responsible for balancing the fluids on the inside of the cells with the fluids on the outside of the cells, as well as maintaining proper blood volume, blood pressure, and fluid pH. Chloride is also important for muscle and heart contraction as well as to aid in the carrying of nerve impulses between our nerve cells and our brain and the rest of the body. Additionally, chloride is needed to help red blood cells exchange oxygen and carbon dioxide in the lungs as well as playing a role in the digestion of foods by supporting hydrochloric acid production in the stomach. We often lose chloride through sweat and perspiration, which comes in the form of water and salt. Replenishment of chloride can come from utilizing salt (often found as sodium-chloride, or table salt), cheese, canned fish, and some processed meats. Overconsumption of some of these foods may not be beneficial for some individuals, so supplementation may be the best way for these individuals to replenish chloride in their bodies.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eSodium (as sodium citrate, sodium bicarbonate)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eSodium, like chloride above, is one of the most essential electrolytes for our body to utilize. As sodium is often found bound to chloride as sodium-chloride (salt), their function and benefits are going to be very similar in nature. Sodium helps to keep the water (amount of fluid outside of the body’s cells) and electrolyte balance of the body, while also aiding in the contraction and relaxation of muscles as well as conducting nerve impulses. While only 500mg of sodium is needed per day for these functions to occur, we as active individuals need far more sodium to maintain these functions. We mostly lose sodium through sweat and urine, so the more active we are\/the more we sweat and the more we urinate, the more sodium is lost. Acquiring enough sodium through food and drink is crucial to establishing equilibrium again to maintain proper functioning and electrolyte balance within the body. The standard American diet is often overloaded with sodium and coupled with inactivity, which can lead to poor health and dysfunction. It is important to engage in physical activity of some kind most days and to eat a diet that is balanced in nutrients to maintain proper health. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003ePotassium (as potassium citrate, coconut water concentrate, potassium glycinate complex)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePotassium, as sodium’s counterpart, acts as a critical electrolyte primarily by helping to maintain normal levels of fluids inside of our cells. Additionally, it helps muscles to contract and relax, aid in strong nerve function, as well as support normal blood pressure. It works very closely with sodium to create the membrane potential needed for the electrical currents that generate these functions to pass from one cell to the next. While the potassium levels in our body are regulated carefully, a diet lacking enough potassium (especially when combined with excess sodium) or one that contains too much potassium can eventually lead to certain types of dysfunctions and poor health status. When potassium levels in the body increase, the adrenal glands release the hormone aldosterone, which causes the kidneys to excrete excess potassium through the urine. When potassium levels are too low, aldosterone levels are suppressed, which can lead to conservation of potassium thus interfering with balance and negatively affecting transport channels that affect vital bodily functions. Potassium can be gotten from the diet in the form of fresh fruits and vegetables, such as sweet potatoes, beans, tomatoes, spinach and broccoli but supplementing can be an essential application as well to support an active lifestyle where excretion is higher than can be replenished through diet.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eVegan Fermented BCAA\/EAA Blend (5g)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIf one were to think of the body as a construction project, amino acids would be the most basic building materials: raw lumber, mortar, bricks, and so on. While the assembly of these building blocks is of course critically important to the function of the building – and one of the amino acids, leucine, controls its own assembly – the quality and availability of the materials themselves is more important. Not enough concrete? The foundation cracks and the building falls.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eYour body is the exact same way. It is comprised of various amino acids, both essential and non-essential, that comprise the cellular basis of each cell in your body. When it comes down to skeletal muscle, the most important are the EAAs – or essential chained amino acids. Comprised of nine amino acids, these compounds effectively control the rate at which your muscle grows (hypertrophies), its contractile force, its endurance, and so on – to say they are massively important is an understatement. For this reason, they form the basis of any competently designed supplement protocol.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCollectively, as stated above, the essential amino acids are famous for their role in skeletal muscle protein synthesis and metabolism. Of the nine, leucine is both the most physiologically important with respect to muscle mass, and the most extensively studied. Data on leucine demonstrate this amino acid plays critical roles in stimulating skeletal muscle protein synthesis, and ribosomal biogenesis and assembly (the literal building of muscle tissue), along with playing a lesser role in insulin signaling and gluconeogenic processes. As a result of these diverse roles, leucine has been demonstrated to significantly stimulate skeletal muscle protein synthesis, and attenuate protein degradation, by both insulin-mediated and non-insulin mediated mechanisms.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eLeucine’s insulin-mediated effects are the result of its activation of the classical insulin receptor substrate (IRS)\/phosphatidylinositol (PI) 3-kinase (PI3K)\/Akt\/mTOR signal transduction pathway. In this pathway, the bonding of a substrate (glucose) eventually activates a compound known as Akt. Once phosphorylated and activated, Akt signals the release of the famous mammalian target of rapamycin (mTOR). mTOR then increases the translation of muscle-cell ribosomal proteins that increase ribosome biogenesis, which is the literal production of proteins. Leucine has additionally been shown to positively regulate protein synthesis independent of insulin. In certain trials where rapamycin and leucine were co-administered, rapamycin showed only partial inhibition of leucine’s effects on muscle protein synthesis.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIn more practical terms, there is a significant body of evidence demonstrating the positive effect of amino acids on athletic performance. Extensive studies in exercise-trained populations reveal that, collectively, amino acids may:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eReduce total muscle soreness after intense resistance training, and\/or further delay its onset.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eDecrease muscle recovery time between bouts of intense resistance exercise training.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eIncrease lean body mass when used daily, in conjunction with diet and exercise.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eL-Taurine\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eThrough traditionally referred to as an amino acid due to its chemical structure, taurine is not an amino acid in the sense that leucine, alanine, or glutamine are. Its chemical status aside, taurine is considered one of the body’s most essential chemical compounds, as cardiovascular function, muscle development and function, along with optical and nervous systems in the body depend on its abundance. While data on taurine typically occurs with taurine in supplement combinations (with caffeine and other amino acids), these data nevertheless suggest that dietary supplementation with taurine may have beneficial effects on mental focus and alertness and may assist during times of increased physical exertion.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eCoconut Water Concentrate (Cocos nucifera)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCoconut water, like the name implies, is the liquid that is found within the coconut itself. Often having a slightly sweet, nutty flavor, it also contains an adequate number of vitamins, minerals, and electrolytes like potassium, sodium, and magnesium. All these electrolytes, like discussed in sections above, can help to boost hydration status and replenish nutrients lost through exercise or rigorous everyday activities. Potassium is the highest concentration in coconut water at 600mg per cup (16% DV), which as discussed about it has a vital role in optimally functioning kidneys and strong muscle contractions. Potassium can also work to keep fluid levels and other electrolytes balanced during exercise. The high concentration of potassium in coconut water specifically can balance our sodium’s effects on blood pressure, and even lower blood pressure slightly, which can have its own benefits towards training and overall health and circulatory health. In addition to the added electrolytes that coconut water can provide, it also can provide a potent number of antioxidants that can aid in the neutralization of free radicals that can rapidly take over during intense training. By eliminating these free radicals, muscles will be able to perform longer and more efficiently, as well as be able to recover adequately. While general water consumption can be adequate as well, the added electrolytes coconut water can supply provides an added benefit that can improve performance and overall recovery.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eElevATP® (Ancient Peat Extract and Apple Extract)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eAdenosine triphosphate and other ATP metabolites are involved in a number of biological processes including cardiac function, blood flow, muscle contraction and neurotransmission. ATP is the primary molecule that acts as a carrier for energy within cells. It has also often been studied that increased levels of ATP have shown increases in health and performance. Supplementation with exogenous ATP has often shown its ability to increase ATP concentrations in blood. Oral supplementation with ancient peat and apple extracts have exhibited their ability to increase intracellular and intramuscular ATP levels. ElevATP® is a blend these specific polyphenols that can work to increase endogenous ATP levels without a simultaneous increase in serum lactate. The significance of this is that usually with an increase in endogenous ATP there is an increase in intracellular free radicals. When these free radicals are not present, oxidative stress is mitigated and there is more potential for the beneficial increases in ATP to take center stage. These increases of ATP are essential as when available energy is increased it can have positive benefits in terms of increased power, strength, and overall exercise performance. One study looked at dosing ElevATP® against placebo and showed that the group who received ElevATP® saw a blood ATP increase of 45% on average along with no increase in oxidative blood glucose. This type of result has been shown repeatedly in studies and has given ElevATP® the reputation to be a beneficial compound for the goals of improving endurance, strength, power, and other training specific adaptations.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eIonic Trace Minerals (as Concentrace® AC)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eOur bodies are high functioning machines and require a lot of support to continue to perform at a high-level day in and day out. A lot of these needs are difficult to be acquired by diet alone, so supplementation is critical. Minerals are included in these daily needs and are vital to the body’s many processes. ConcenTrace® AC is a high-quality trace mineral complex providing a comprehensive blend of nutrients that are often hard to acquire from diet alone. Its manufacturing process makes it up to 26x more concentrated than other colloidal trace minerals, adding to its benefits. These minerals contained in the product are catalysts for all the vitamins and other nutrients our body requires to function at an optimal level and maintain health. Some of these functions include electrolyte replacement, maintaining pH balance in the body, nourishing hair and skin, strengthening bones and joints, regulating the digestive system, and improving athletic performance.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eAstraGin® (Astragalus membranaceous and Panax notoginseng root extracts)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eAstraGin® is a trademarked combination of \u003c\/span\u003e\u003cspan\u003eAstragalus membranaceous\u003c\/span\u003e\u003cspan\u003e and \u003c\/span\u003e\u003cspan\u003ePanax notoginseng\u003c\/span\u003e\u003cspan\u003e that has been widely used in the supplement manufacturing industry for due to its clinically studied benefits for improving absorption of nutrients, peptides, and amino acids. Some statistics include increased absorption of creatine, leucine, citrulline, and other peptides by up to 67%, increased curcumin absorption by 92%, increases polyunsaturated fatty acids (from flax and fish oil) by 58% and 100% respectively, as well as can increase ATP production in the liver by 18%. AstraGin® has been shown capable of increasing muscle protein synthesis and increased mTOR through enhanced leucine absorption, which has an influence on improved glucose metabolism and mitochondrial functions. In addition to this benefit, AstraGin’s® ability to enhance polyunsaturated fatty acid absorption while also inhibiting saturated fatty acid absorption, thus reducing the risk of impaired glucose metabolism and mitochondrial function, can enhance ATP synthesis through mitochondrial respiration, and increase oxidative phosphorylation.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIt has been further studied how Astragalus and \u003c\/span\u003e\u003cspan\u003ePanax notoginseng\u003c\/span\u003e\u003cspan\u003e specifically can protect mitochondria and enhance their function towards anti-aging. The proposed mechanism leads to Astragalus acting as a free radical scavenger, which can inhibit mitochondrial permeability transition and increase the activity of antioxidants against the peroxidation of membrane lipids. \u003c\/span\u003e\u003cspan\u003ePanax notoginseng\u003c\/span\u003e\u003cspan\u003e also works in a similar fashion through decreased free radical production. This lipid peroxidation has been shown to be a major cause of decreases in mitochondrial function. In addition to this, ensuring a highly permeable environment around the mitochondrial membrane is crucial for maintaining mitochondrial functions. This permeability allows for the passage of key electro chemicals to cross the gradient allowing for the process of energy development for the cells.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/TF-Allspark-MixedBerryKiwi-11.25x5.25.pdf?v=1726131233\"\u003e\u003cspan\u003eMixed Berry Kiwi Label\u003c\/span\u003e\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/TF-Allspark-SourLemonCandy-11.25x5.25.pdf?v=1726131325\"\u003e\u003cspan\u003eSour Lemon Candy Label\u003c\/span\u003e\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/TF-Allspark-BloodOrangePassionFruit-11.25x5.25.pdf?v=1726131611\"\u003e\u003cspan\u003eBlood Orange Passion Fruit Label\u003c\/span\u003e\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/REFFERENCES-Transformers-Allspark.pdf?v=1727078181\" target=\"_blank\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Grape Lemonade (Starscream)","offer_id":53256728183094,"sku":"850057789638","price":209.52,"currency_code":"AED","in_stock":true},{"title":"Mixed Berry Kiwi (Optimus Prime)","offer_id":53256728215862,"sku":"850057789416","price":209.52,"currency_code":"AED","in_stock":true},{"title":"Sour Lemon Candy (Bumblebee)","offer_id":53256728248630,"sku":"850057789423","price":209.52,"currency_code":"AED","in_stock":true},{"title":"Blood Orange Passion Fruit (Megatron)","offer_id":53256728281398,"sku":"850057789430","price":209.52,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/ALLSPARK_GRAPELEMONADE_FRONT_77410880-1289-428e-8aae-b059b3c9a51f.png?v=1762807450"},{"product_id":"daily-health-pack","title":"Daily Health Pack","description":"\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eWe understand that being consistent with taking all your supplements can be tough, especially when your lifestyle is busy and schedule is full. At Core Nutritional’s®, we recognize this and put together a convenient daily packet that has everything you need to support your Crush It® lifestyle inside and outside of the gym. We’ve packed a combination of micronutrients, omega-3, probiotics, greens and reds, and products to support vital joints and organs, that can be highly beneficial to their overall function. Overall, a convenient daily pack of these supplements can help individuals maintain their health, support key body functions, and optimize well-being, even during a hectic and unpredictable lifestyle.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eB Vitamins (Thiamine, Riboflavin, Niacin, B6 [Pyridoxine], Folic Acid, B12, Biotin, and Pantothenic acid)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eB vitamins are a group of eight essential vitamins with several critical functions in the body. Though both molecularly and physiologically distinct, they are also deeply interrelated in their effects, synthesis, and metabolism. Among the B-complex’s many critical roles are energy (protein, carbohydrates, and fat) metabolism, supporting and maintaining the healthy function of the adrenal glands, skeletal muscle function, and digestion.\u003c\/p\u003e\n\u003cp\u003eWhile rates of metabolism and clearance differ between each B vitamin, all B vitamins are water-soluble and are thus not stored in fat. As a result, the body simply excretes excess B vitamins in the urine and requires replenishment (from food or supplements) to maintain the cell functions to which B vitamins contribute.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin A (as retinyl palmitate)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBeta carotene is itself not an essential vitamin but is rather the precursor to the fat-soluble and essential vitamin, vitamin A (Retinol). Like B vitamins, the term vitamin A refers to the compound class retinoids, comprised of retinol, retinal (also called retinaldehyde), retinoic acid, and provitamin A compounds such as beta carotene.\u003c\/p\u003e\n\u003cp\u003eAs their names suggest, retinoids are critical to the function of human eyes and therefore to the maintenance of circadian rhythms (our “biological clock”). Vitamin A combines with proteins in the eye to form light-sensing cells that both facilitate vision and regulate our sleep-wake cycles.\u003c\/p\u003e\n\u003cp\u003eBeyond its role in sight, vitamin A is also essential for cellular growth and differentiation and the immune system.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin C (as Ascorbic Acid)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVitamin C is perhaps historically best-known for the treatment and prevention of scurvy, though it has many other roles in the body. For example, vitamin C catalyzes or is a cofactor in eight enzymatic reactions involved in the synthesis of collagen, the nutrient carnitine, and several neurotransmitters necessary for the proper function of the brain.\u003c\/p\u003e\n\u003cp\u003eIn the contemporary context, vitamin C is best known as a potent antioxidant. In addition to its intrinsic activity as an antioxidant, vitamin C has been shown in in vitro trials to regenerate alpha-tocopherol (vitamin E). As an antioxidant, vitamin C combats the detrimental effects of a group of compounds called radical oxygen species that, when produced, degrade the lipid membrane of the cell, and may cause internal damage. By “scavenging” these free radicals, vitamin C and other antioxidants form a defense against excess cellular damage.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin D3 (as Cholecalciferol)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVitamin D, in its various forms, is not an essential nutrient – as it is produced endogenously within the body, as a reaction to the skin’s exposure to the sun – and thus not commonly considered a vitamin. Despite its technical classification, vitamin D (a hormone), is nevertheless an import and biologically-active compound, necessary for the calcium homeostasis and metabolism, along with increasing the absorption of magnesium and phosphate.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin E (as dl-alpha tocopherol acetate)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVitamin E is another technical misnomer, as the term refers to a group of compounds known as tocopherols with eight biologically-active constituents: alpha-, beta-, gamma-, and delta-tocopherol and alpha-, beta-, gamma-, and delta-tocotrienol. Alpha-tocopherol is the principal bioactive in humans, though the presence of other tocopherols has been linked to beneficial effects.\u003c\/p\u003e\n\u003cp\u003eAs a result of its robust antioxidant activity, vitamin E assists in the maintenance and support of several physiological processes, though most notably sight and the immune system. Emerging research also suggests that the alpha-tocopherol form of vitamin E inhibits an enzyme known as protein kinase C, and therefore contributes to the healthy regulation of smooth muscle cell growth and differentiation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCalcium (as dicalcium malate (DimaCal®)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWhile best-known as the main bioactive in milk, and a compound that contributes to strong bones, calcium has numerous physiological effects in the body – including mediating vascular contraction and vasodilatation, muscle function, nerve transmission, intracellular signaling, and hormonal secretion. Homeostatic regulation of calcium, which the body cannot produce, requires sufficient levels of vitamin D.\u003c\/p\u003e\n\u003cp\u003eWhen present in sufficient amounts, calcium is necessary for the adequate formation, function, and remodeling of both bone and teeth. Insufficient levels of calcium are associated with degenerative bone and joint disorders such as osteoporosis, wherein bone accretion slows or stops; thereby reducing bone mass and density and decreasing bone strength.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIodine (as potassium iodide)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIodine is a trace element naturally present in certain foods, including kelp. Iodine is a critical component for fetal development, especially during early pregnancy, as maternal T4 (thyroxine) is the sole source of fetal thyroid hormone. After birth, especially if breast-feeding, iodine remains an important constituent of a balanced-diet to maintain adequate T3 (triiodothyronine) and T4 (thyroxine) levels in the mother and for the proper cognitive development in the child.\u003c\/p\u003e\n\u003cp\u003eAs implied, however, the most important of iodine’s functions is assisting the body to produce and maintain healthy levels of both thyroid hormones and TSH (thyroid stimulating hormone, released by the pituitary). The thyroid hormones, in turn, regulate several critical biochemical reactions, including protein synthesis, and, along with norepinephrine\/epinephrine, largely determine the body’s metabolic rate.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMagnesium (as Di-Magnesium Malate)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIt is difficult to overstate the biological necessity of magnesium. Magnesium is a co-factor in over 300 enzymatic reactions that regulate essential physiological functions such as protein synthesis, glucose homeostasis, muscle and nerve function, and the maintenance and support of healthy blood pressure levels.\u003c\/p\u003e\n\u003cp\u003eMagnesium is also required for the use of the body’s energy currency, ATP. To become biologically active, ATP must be bound to magnesium to form Mg-ATP. In addition, magnesium is necessary for the proper function of cells with calcium and potassium gated ion channels such as heart and muscle cells.\u003c\/p\u003e\n\u003cp\u003eIn men, magnesium (along with zinc) is necessary for the maintenance of healthy levels of testosterone.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eZinc (as Zinc Aspartate)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAs an essential mineral, like magnesium, zinc is also involved in a wide-range of essential biological functions in the human body – and a requirement in the catalytic activity of over 100 enzymes.\u003c\/p\u003e\n\u003cp\u003eMost notably, zinc is vital for immune function, protein synthesis, cellular division, and DNA synthesis. For immune function, zinc is required for the function of a group of immune cells known as neutrophils and macrophages, which eliminate pathological cells and their products from the body.\u003c\/p\u003e\n\u003cp\u003eWith magnesium, sufficient levels of zinc are also necessary for the production and maintenance of healthy levels of testosterone.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCopper (as Copper Bisglycinate Chelate)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCopper is a trace element necessary for the production, function, and maintenance of a diverse range of compounds involved in physiological function.\u003c\/p\u003e\n\u003cp\u003eThe brain, the heart, bone, and connective tissue specifically require copper or the enzymes it catalyzes to properly grow and differentiate their various cell types. Like many of the ingredients in Core MULTI, copper is also required for the homeostasis of other minerals, specifically zinc.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eManganese (as Manganese Citrate)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eManganese is a required element for not only humans, but all living organisms. Manganese primarily acts as an antioxidant, specifically scavenging a radical oxygen species known as superoxide.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eChromium (as Chromium Picolinate)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eChromium is an essential, though little understood, trace element found in certain foods and industrial compounds. Only one of chromium’s two forms, the form used in Core MULTI, chromium 3+, is biologically active.\u003c\/p\u003e\n\u003cp\u003eWhile not as well-defined as other trace elements, chromium’s physiological actions nevertheless seem pivotal to the production and transmission of healthy levels of insulin. Emerging research also seems to suggest that chromium is directly involved in the metabolism of carbohydrates.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMolybdenum (as Molybdenum Glycinate Chelate)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMolybdenum is an essential trace element, involved in at least four enzymatic reactions necessary for urea excretion and several other physiological functions.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch3\u003eGREENS\u003c\/h3\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eChlorella and Spirulina Powder:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eChlorella and spirulina are the organisms behind the most common forms of green and blue\/green algae, respectively. Chlorella has been variously classified as either a plant or a protist, while spirulina is a kind of cyanobacteria and thus classified as a bacterium. Regardless of the taxonomical differences between chlorella and spirulina, emerging evidence suggests that both have a range of benefits for human health.\u003c\/p\u003e\n\u003cp\u003eThe first benefit is that the macronutrient constituents in the plants themselves are favorable. Spirulina is a source of high-quality protein, γ-linolenic acid, and phycocyanin content. Chlorella, in turn, contains a variety of bioactives, including nucleic acids, amino acids, vitamins, minerals, polysaccharides, glycoproteins, and β-glucans.\u003c\/p\u003e\n\u003cp\u003eIn addition to their macronutrient content, both chlorella and spirulina contain bioactive compounds that emerging evidence suggests have potential health effects. Polypeptide chains isolated from chlorella, for example, were shown in in vitro and animal models to be potent ACE inhibitors. ACE (angiotensin converting enzyme) is an enzyme that catalyzes the conversion of inactive Angiotensin I (AG-I) to the active Angiotensin II (AG-II). In turn, AG-II binds to the Angiotensin II receptor in smooth muscle and elicits the production of aldosterone – creating a hypertensive effect through direct and indirect means. While still preliminary, evidence suggests that the isolated polypeptides in chlorella may be ACE inhibitors.\u003c\/p\u003e\n\u003cp\u003eSimilar trials on the reduction of HbA1C, for example, demonstrate that these microalgae and their constituent parts may indeed be superfoods.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhytoServ® Fruit Blend and Veggie Blend\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePhytoServ® is a proprietary blend of plant-based extracts that condenses voluminous micronutrient sources into easy to deliver clinical doses that provide powerful antioxidant containing phytonutrients that can protect the body’s immune system from the harmful effects of oxidative stress. In the Fruit Blend you will receive a combination of:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eGrape Seed Extract\u003c\/li\u003e\n\u003cli\u003eWild Blueberry Extract\u003c\/li\u003e\n\u003cli\u003eRaspberry Extract\u003c\/li\u003e\n\u003cli\u003eCranberry\u003c\/li\u003e\n\u003cli\u003ePrune\u003c\/li\u003e\n\u003cli\u003eTart Cherry\u003c\/li\u003e\n\u003cli\u003eWild Bilberry Extract\u003c\/li\u003e\n\u003cli\u003eStrawberry\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003eIn the Veggie Blend you will receive:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eBroccoli Sprout\u003c\/li\u003e\n\u003cli\u003eOnion Extract\u003c\/li\u003e\n\u003cli\u003eTomato\u003c\/li\u003e\n\u003cli\u003eBroccoli\u003c\/li\u003e\n\u003cli\u003eCarrot\u003c\/li\u003e\n\u003cli\u003eSpinach\u003c\/li\u003e\n\u003cli\u003eKale\u003c\/li\u003e\n\u003cli\u003eBrussels Sprout\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003eIn the Core DAILY HEALTH PACK, we have included both the Fruit Blend and Veggie Blend so there are no gaps to your micronutrient protection.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch3\u003eBRAIN\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAlpha-GPC 50%\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eOf the known choline pro-drugs or precursors, Alpha GPC appears to have exert the greatest influence on circulating choline levels. Choline is an essential nutrient involved in numerous metabolic pathways, including DNA regulation and repair, protein function, and metabolism. Perhaps most importantly, the critical neurotransmitter acetylcholine is produced directly from free choline via cholinergic neurons. Acetylcholine is then responsible for several functions itself, most crucially as the compound which induces muscular contraction, and as the neuromodulator partially responsible for modulating risk\/reward, arousal, and enhancing memory.\u003c\/p\u003e\n\u003cp\u003eCholine’s essential role as a substrate for acetylcholine, and therefore brain development, is well documented in animal models. These studies demonstrate that levels of free maternal choline have a direct and fundamental impact on prenatal brain development, with the enhancements or deficits lasting into adulthood. Choline’s enhancing effect is particularly prominent in the hippocampus. In humans, the hippocampus is primarily involved in the consolidation of memory (taking short, episodic memory and translating it into long-term memory) and the learning of new information. Acetylcholine is a critical component in these processes, as mentioned above, and choline may therefore play a potential role in these processes as well by providing the substrate for acetylcholine synthesis.\u003c\/p\u003e\n\u003cp\u003eWhether through these, or other independent mechanisms, a recent trial using Alpha GPC demonstrated a statistically significant increase to power output. In a placebo-controlled, double-blind, randomized trial, 14 healthy volunteers, split into an Alpha GPC or placebo group, were tested on various exercises. In comparison to the placebo group, the Alpha GPC group experienced a 14% increase to bench press. The researchers hypothesize that the peak power increase was the result of a substantial acute increase to growth hormone, one of the observed effects of Alpha GPC supplementation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBacopa Extract (50% Bacopasides) (Bacopa monnieri L.) (Leaf)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBacopa monnieri, also known as the water hyssop commonly, or as Brahmi in Ayurvedic texts, is a small creeping herb endemic to sub-tropical India. The herb has been used in traditional Indian medicine for well over one thousand years, with its first recorded usage coming in the 6th century A.D. In this traditional context, BM has been used for a wide-range of purposes, including as a treatment of asthma and epilepsy.\u003c\/p\u003e\n\u003cp\u003eMore recently, BM has been the subject of numerous cognition and memory trials, as the plant has a well-established nootropic effect. Likely through modulation of the serotonin reuptake system, clinical trials in healthy humans have demonstrated that BM possesses a significant effect on the retention of newly-learned information. In several trials utilizing a 300mg daily serving, BM was also shown to decrease the recall delay of newly learned information and reduce short term forgetfulness – suggesting that the herb’s effect on the serotonic and cholinergic systems are increasing the encoding (the literal storing) of memory information.\u003c\/p\u003e\n\u003cp\u003eBeyond cognition and memory encoding, BM has also been demonstrated to function as a potent adaptogen and relaxant – which in the Core DAILY HEALTH PACK brain formula may help to smooth the effect curve of the product’s stimulants, reducing jitteriness or, “crash.”\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCoffee Fruit Extract (Coffea arabica) (Fruit) (CognatiQ®)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCognatiQ®, an extract derived from the whole fruit Coffea arabica plant, is a clinically proven ingredient shown to stimulate the production of the neuroprotein, Brain-Derived Neurotrophic Factor (BDNF). BDNF has been shown to be crucial in the development, maintenance and repair of neurons and also protect against neuro-degeneration. One study comparing other coffee, caffeine, and polyphenol compounds, showed that they were not statistically significant in increasing BDNF % compared to CognatiQ®. The unique polyphenol profile found in CognatiQ® showed to be superior in increasing BDNF concentration.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHuperzia serrata Extract (std. 1% Huperzine A)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eHuperzia serrata is a compound found in the plant families of Huperziaceae, Lycopodiaceae, and Selaginella and is endemic to China. The Lycopodium alkaloid Huperzine-A, found in Core ZONE, was first isolated from a folk medicinal preparation in 1984.\u003c\/p\u003e\n\u003cp\u003eThis potent compound has been evaluated in numerous in vitro, in vivo, and human trials. These data suggest that Huperzine A’s mechanisms of action are most potent in the cortex, hippocampus, and striatum (at least in rats) – key regions in the brain responsible for forming, coordinating, and recalling memory. These effects are assisted by Huperzine A’s high oral bioavailability. Studies using microdialysis technique in rats, for example, showed that the response to Huperzine A was dose-dependent and substantially lowered the level of ACh in cortex.\u003c\/p\u003e\n\u003cp\u003eHuperzine A has also shown promise in humans. Referred to as an inhibitor of acetylcholinesterase, Huperzine A has shown positively impact cognition and memory. This is partly due to its inhibitory factors on acetylcholinesterase (an enzyme that breaks down acetylcholine), which results in an increase in acetylcholine. Acetylcholine is known as a learning neurotransmitter so increased levels can be beneficial towards memory, and other neural improvements. In another study on memory and learning performance, 34 pairs of middle school students complaining of memory inadequacy were given a small dose of Huperzine A. The students were then match paired along several vectors and provided tests on working memory. The results of this study exhibited that HupA markedly improved the memory function of adolescent students.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch3\u003eJOINT\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eTurmeric Extract (95% curcuminoids) (Curcuma longa) (Root)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eTurmeric is a root endemic to certain regions of Southeast Asia and India, and has been a staple in the Siddha traditional medicinal system for thousands of years. Turmeric is noted in Siddha texts for various uses, including as an ancient equivalent of an anti-microbial agent.\u003c\/p\u003e\n\u003cp\u003eMore recently, numerous studies seem to suggest that its primary bioactive constituent, curcumin, powerfully inhibits the enzymes that synthesize inflammatory compounds such as prostaglandins and leukotrienes. Basic research and molecular studies have now firmly established curcumin’s ability to dose-dependently and potently inhibit a transcription factor known as NF–kB – a molecule involved in the proliferation of pro-inflammatory cytokines, soft tissue destruction, and autoimmune responses.\u003c\/p\u003e\n\u003cp\u003eThough Turmeric contains approximately 5% curcumin by weight, we have used a highly standardized extract of 95% - recognizing that the wealth of research on curcumin demands that it be included in clinical serving sizes.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethylsulfonylmethane (MSM)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMSM is a naturally occurring, organosulfur molecule that can be synthesized both naturally and synthetically from DSMO. While the majority of MSM present in the human body is ingested – either deliberately or accidentally – the compound does have a natural presence in certain tissues and fluids in the body, including cerebrospinal fluid. MSM appears to assist healthy biochemical communication between cells that may assist joint flexibility and mobility. While still emerging, certain data on MSM appears to show a promising role for the compound in the maintenance of proper joint function. Several studies demonstrate joint function increases on the WOMAC scale ranging from 20-35%, while animal data suggests equally significant results. Though not every trial on MSM reveals such significant results, a meta-analysis conducted in 2011 found that the overwhelming majority of clinical MSM trials featured function improvements over placebo.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBioPerine® Black Pepper Extract (Piper nigrum) (Fruit)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBioPerine® is a patented standardized extract from the fruit of Piper nigrum (black pepper). It’s studied benefits have continually shown improvements in bioavailability of nutrients it is surrounded by. When it comes to post exercise nutrition, efficiency and speed with which nutrients can enter the system and get to their target is of the upmost importance. The “window of opportunity” is much larger than what has been previously thought, but when your results weigh heavily on post-exercise nutrition, maximal absorption and use of nutrients is extremely important.\u003c\/p\u003e\n\u003cp\u003eBioPerine® primarily works through mechanisms and channels that can inhibit intestinal motility and dilate blood vessels of the intestines (where absorption of nutrients occurs). This physiological action may cause increased absorption and digestion of nutrients.\u003c\/p\u003e\n\u003cp\u003eSeveral studies looking at BioPerine®’s impact on oxidative stress have been performed. One study conducted on rats in 2013 looked at the influence of piperine on rats with developed disorders such as hypertension, increased inflammatory markers, and increased plasma liver enzymes after being fed a high carbohydrate and high fat diet. The results showed that after 16 weeks of supplementation with piperine these rats experienced normalized blood pressure, improved glucose tolerance, reduced markers of oxidative stress and inflammation, and improved liver function.\u003c\/p\u003e\n\u003cp\u003eWith more promising research being done on the effects of BioPerine® in the context of nutrient absorption, bioavailability, and its influence on certain health markers, it is only fitting that we include it in Core Life Line’s Liver support product.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch3\u003eHEART AND LIVER\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eMilk Thistle Extract (Silybum marianum) (Seed)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSilybum marianum, also known as milk thistle, is a medicinal thistle from the aster or daisy family that has been used in traditional medicines for many centuries for treatment of many different diseases. Many of these treatments have been to protect the liver and associated organs from damage\/further damage. There is evidence to support that milk thistle, and specifically the silymarin compound that is found within it, exhibits a mechanism of action for hepatoprotection from free radicals through antioxidant activity, enhanced protein synthesis, and possible anti-inflammatory or immunomodulating effects. These free radicals are generated through the damage to cellular membranes called lipoperoxidation. Additionally, silymarin also enhances liver glutathione production through the inhibition of hepatocyte glutathione reduction. This can further contribute to the antioxidant support and defense for the liver. Several studies have shown improvements in liver function in individuals with certain liver diseases leading to these proposed benefits. In one in vitro human study, silymarin was shown to inhibit T-cell proliferation and proinflammatory cytokine secretion in a dose-dependent manner. Higher doses of silymarin were shown to specifically control hepatic inflammation responses in chronic liver diseases. It is important to note that in relation to liver diseases, milk thistle has been studied as a complimentary treatment method to traditional treatments and that it is important to live a healthy lifestyle to prevent these diseases as much as possible.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHawthorn Berry Extract (Crataegus pinnatifida) (Fruit)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eHawthorne has been utilized for many centuries for its wide range of health benefits. One of these primary benefits is how it positively affects the cardiovascular system. The berries, or fruit, of the plant contain high amounts of bioflavonoids and proanthocyanins, substances shown to contain most of the health promoting qualities. These antioxidants have several mechanisms of action on the cardiovascular system. Hypotensive (lowering blood pressure) improvements can be seen through vasorelaxation through the stimulation of nitric oxide production. Several studies have investigated this benefit on blood pressure as well. One human study conducted on individuals with high blood pressure showed that the administration of 1200mg of Hawthorn Berry (slightly more than what we use in this product), noticed substantial improvements in blood pressure when compared to placebo.\u003c\/p\u003e\n\u003cp\u003eHawthorne Berry can also play a role in preventing atherosclerosis, or a buildup of plaque in the blood vessels that occurs due to an imbalance in blood fat levels (typically high triglycerides and low HDL cholesterol). If this plaque continues to accumulate, it can lead to blockages in the blood vessels carrying blood to vital organs, ultimately resulting to heart attack or stroke. Anti-atherosclerotic improvements can be seen through the downregulation of capsase-3 gene expression. The capsase-3 gene is known for being a proapoptotic (cell killing) gene that has been reported in heart failure and myocardial infarction (heart attack). The regulation of lipoprotein lipase (regulates the delivery of fats to body tissues) expression and raised excretion of bile acids can also benefit the arteries. Several animal studies have examined the positive impact of Hawthorne Berries on cholesterol. One study on mice showed that mice given the extract resulted in a lower total and LDL cholesterol, as well as between 30-45% lower liver triglyceride levels compared to mice that were not administered the extract.\u003c\/p\u003e\n\u003cp\u003eOn cardiac cells, these antioxidants downregulate capsase-3 gene expression and inhibit 3’,5’-cyclic adenosine monophosphate phosphodiesterase, which can result in an increase in coronary flow, increase in relaxation velocity, and cause a positive inotropic effect (increase the strength of heart muscle contraction).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCoenzyme Q 10 (ubiquinone)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCoenzyme Q10, which is synthesized in the mitochondrial inner membrane, is an essential compound that plays many vital roles in the human body. Of these many roles, it is a key component in the electron transport chain in mitochondria necessary for ATP production. CoQ10 can also act as an intercellular antioxidant, protecting the plasmatic membrane against peroxidation. CoQ10 deficiency has been associated with less-than-optimal health status in organisms and has contributed to certain degenerative states involving blood sugar, the cardiovascular system, and musculoskeletal system. In relation to the cardiovascular system, oxidative stress is one of the main causes of cardiac decline. The antioxidant properties of CoQ10 are of particular importance in establishing normal function. It has been shown that individuals suffering from cardiac related abnormalities have significantly lower levels of CoQ10 as opposed to those with higher levels. With antioxidant effect and free radical neutralization being the primary mechanism of action, CoQ10 exhibits a secondary mechanism of action of well in playing a large role in the heart’s energetic needs. The process of cardiac contraction requires the release of Ca2+ from the SR and the following activation of the contractile proteins requires energy. It is believed that when there is myocardial failure, it is caused by a reduction in the production of energy from the mitochondria. This goes back to CoQ10s property of being a main component in the transport of electrons that are needed for ATP production. These two mechanisms of action have a particular importance for one’s quality of life as well as in maintaining proper cardiovascular function.\u003c\/p\u003e\n\u003ch3\u003e\u003cbr\u003e\u003c\/h3\u003e\n\u003cp\u003ePROBIOTIC\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBromelain (Ananas comosus) (pineapple stem)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBromelain is a collection of protein-digesting enzymes found in pineapple juice and in the stem of pineapple plants. It has been shown to have a myriad of health benefits including speed of recovery, antioxidant properties, and assisting cardiovascular and circulatory health. The mechanism of the anti-inflammatory activity is not very well understood, but like curcumin and Boswellia it appears to support inflammatory marker balance. Numerous studies have shown bromelain’s ability to assist and speed recovery time following various health related procedures.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInulin\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eInulin is a readily fermentable fiber by intestinal bacteria that can generate short chain fatty acids, which possess anti-inflammatory, immunoregulatory, cardioprotective, hepatoprotective, and neuroprotective benefits. Inulin is especially beneficial when it comes to its effectiveness on the gut, such as reduced pH of the intestines, thus providing relief from GI distress and constipation which can lead to increased stool volume. Inulin has also shown effectiveness on reducing adipocyte size as well as improved glucose tolerance and an increase in energy expenditure.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDigestive Enzyme Blend (DigeSEB®)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eOne can easily make the argument that dietary enzymes – and, digestive enzymes – are the most consistently underrated and overlooked component to a supplementation regimen. These powerful little protein structures influence or outright control a vast, complex network of bodily functions. In a fitness-specific context, digestive enzymes play a crucial role in the breaking down of dietary carbohydrates, fats, and proteins into their constitutive parts, and therefore allow your body to use them in various processes (glycogenesis, protein synthesis, etc.).\u003c\/p\u003e\n\u003cp\u003eDespite their critical function, many supplement companies overlook the necessity of digestive enzymes and do not include sufficient levels (and kinds) of enzymes in their products.\u003c\/p\u003e\n\u003cp\u003eAs usual, we take a much more comprehensive, clinical approach than the average. In Core Life Line’s Gut product, we have included a digestive enzyme blend comprised by:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eProteases- breaks down proteins and other peptides\u003c\/li\u003e\n\u003cli\u003eLactases- breaks down lactose\u003c\/li\u003e\n\u003cli\u003eAmylases- breaks down starches into useable sugars, such as glucose and maltose\u003c\/li\u003e\n\u003cli\u003eLipases- breaks down fats\/lipids which allow for a full and complete breakdown of all your daily dietary components.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eProbiotic Blend (10 Billion CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eUnder normal conditions, our gut microbiota – the constellation of intestinal flora that play innumerable physiological roles – are balanced between “good” and “bad” bacteria. The good bacteria confer immunity to us from pathogens, improve digestion of food, help regulate mood and more – while the “bad” bacteria cause a range of pathological conditions, invite pathogens, and generally wreak havoc on our bodies. The point of a well-designed probiotic is maintaining this intestinal balance in the “good” direction.\u003c\/p\u003e\n\u003cp\u003eUsing a probiotic supplement helps offset the microbiotic impact of stressors such as illness, medications (antibiotics), hormonal variations, and an incomplete diet. While the evidence is still emerging, the potential health benefits of probiotics have been seen in many conditions.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch3\u003eOMEGA 3\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eNitrogen Barrier Production\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eOil derived from marine animals – commonly referred to as “fish oils” – are widely consumed for the high amounts of polyunsaturated fatty acids (such as DHA and EPA) that they contain and the potential health benefits that these fatty acids confer. Unfortunately, polyunsaturated fatty acids are notoriously unstable: they are composed of double-bonds between carbon atoms, a chemical structure that is notoriously susceptible to oxidation. (Oxidation is the process of producing oxygen species because of a compound’s exposure to oxygen.)\u003c\/p\u003e\n\u003cp\u003eFor fish oil, oxidation has a few deleterious effects – principally, the production of hydroperoxides (the first step in oxidation) and secondary oxygen products not only produce the rancid, “fish” smell typically associated with lower quality fish oil products; but perhaps more importantly, in breaking the double bond structure of the fish oil, these oxygen species degrade the integrity of the product and thus reduce their potential health benefits. The oxidation degradation is unfortunately widespread. One study found that 50% of 171 fish oil supplements in Canada exceeded the limits for at least one measure of oxidation, and 39% exceeded the international voluntary safety recommendations for total oxidation (TOTOX value).” Another study found that approximately 29% of fish oil supplements in the United States similarly exceeded recommended values.\u003c\/p\u003e\n\u003cp\u003eLuckily, research has shown that reducing the exposure of fish oils to oxygen and environmental factors (humidity and temperature fluctuations) during the production process can significantly mitigate oxidation. One of the most effective ways to reduce oxygen exposure is to blanket the oil, as soon as its processed and produced, in an inert gas such as argon or nitrogen – thereby preventing the fish oil from encountering oxygen at all. While exact values will vary by product, research has shown that both primary oxidation (the production of hydroperoxides, measured in peroxide value, PV) and secondary oxidation (measured in TOTOX (total oxidation value) and a-nsidine values) are vastly reduced through a nitrogen blanket or barrier.\u003c\/p\u003e\n\u003cp\u003eIn sum, producing fish oils under a nitrogen blanket or barrier not only reduces the rancid smell typically associated with fish oil products; but vastly extends their shelf life and integrity.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTriglycerides vs Ethyl Ester Forms\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWe have established that how fish oils are produced may impact their viability as a dietary supplement. But the production process is not the only salient factor in fish oil efficacy and viability – the form that a fish oil takes is paramount, as well. Specifically, the differences between triglycerides and ethyl esters may be formative in how fish oils are absorbed and confer their potential health benefits.\u003c\/p\u003e\n\u003cp\u003eFirst, a little primer on what triglycerides and ethyl esters are. Triglycerides are a molecular form common to almost all plant and animal species: a glycerol backbone with three fatty acids (in the case of fish oils, EPA, and DHA) attached to them. For example, the “stuff” of human adipose (fat) tissue is triglycerides. Ethyl Esters, on the other hand, lack a glycerol backbone – they are a single fatty acid molecule attached to an ethanol molecule. Unlike triglycerides, ethyl esters are not a natural molecular form and formed solely through chemical synthesis.\u003c\/p\u003e\n\u003cp\u003eWhile the difference between triglycerides and ethyl esters as applied to fish oil may seem academic, it in fact has profound implications for the absorption and bioavailability of these oils. In very condensed form, the issue is twofold: how the fish oil is taken up into the bloodstream (absorption) and how it is made available to cells once that has occurred (bioavailability). In both contexts, there is evidence that triglycerides are superior to the ethyl ester form.\u003c\/p\u003e\n\u003cp\u003eFor bioavailability, the issue is how the small intestine breaks down each form of fish oil. As a natural product, our bodies are intrinsically capable of breaking down triglycerides via bile salts and pancreatic lipase. Once ingested, pancreatic lipase and bile salts are released, and in the small intestine, the triglyceride is broken down into so-called emulsion droplets – which can then easily be broken up, detaching the two fatty acid molecules from the glycerol backbone. Not so with ethyl esters. Not only is pancreatic lipase (by some estimates) 50% less effective in breaking down ethyl esters; but once digested, ethyl esters must be converted into triglycerides through the liberated fatty acids attaching to a glycerol molecule. Essentially, your body must reverse the entire metabolism of ethyl esters, then go through the normal triglyceride metabolism.\u003c\/p\u003e\n\u003cp\u003eThe biochemical differences between triglycerides and ethyl esters have been demonstrated in trials examining bioavailability and absorption efficiency. One study found that, when ingested in triglyceride form, EPA and DHA levels were 340% and 271%, respectively, as compared to the ethyl ester form. Additional research has found a 25% increase in plasma EPA and DHA levels over a six-month period; that ethyl esters are “poorly absorbed” by man; and that triglyceride form fish oils suffer less oxidation (on shelf) than the ethyl ester form.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch3\u003eEPA and DHA\u003c\/h3\u003e\n\u003cp\u003eNow that we know why producing fish oils under nitrogen barrier protects the integrity of fish oil, and why triglycerides are superior to ethyl esters, we have only one major question left: what benefits do fish oils (specifically, EPA and DHA) pose to humans?\u003c\/p\u003e\n\u003cp\u003eEicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have myriad health benefits, but their best-studied (and approved by the FDA) use is to balance and maintain healthy triglyceride levels. Triglycerides, as we mentioned, are produced naturally by most animals. They are necessary for a wide range of physiological function, but their overabundance is implicated in several pathological conditions. Consequently, ingesting external forms of triglycerides – such as fish oils – can help balance triglycerides and maintain healthy levels. In perhaps the most robust meta-analysis to date, researchers examined 11 randomized human trials, comprised of 485 total individuals with a mean age of 25 to 49. The meta-analysis found robust evidence that DHA, specifically, exerts a significant triglyceride lowering and balancing effect. A similar meta-analysis focused on EPA found that its effects were comparable to DHA.\u003c\/p\u003e\n\u003cp\u003eBoth polyunsaturated fatty acids are best known for their triglyceride-lowering function, each exerts other interesting effects as well. Significant evidence suggests that EPA and DHA may mitigate the production of pro-inflammatory cytokines, molecules responsible for inducing the inflammation cascade in the body. Others studies suggest high levels of brain DHA are associated with verbal fluency and memory in healthy, normal adults – with one study finding that 6 months of DHA supplementation in young, healthy adults increased working memory assessed by recall.\u003c\/p\u003e\n\u003cp\u003eOne of fish oil’s (specifically, EPA’s) effects that may be of interest to fitness and physique athletes is its ability to induce AMPk (adenosine monophosphate kinase). AMPk, otherwise known as the “master metabolic switch,” is a heterotrimeric enzyme responsible for energy catabolism in muscle and fat cells. When activated, AMPk increases lipolytic (the catabolism of fat tissue) signaling as a means of energy provision. Several studies demonstrate that high levels of EPA indirectly stimulate AMPk activation via decreasing PPARy.\u003c\/p\u003e\n\u003cp\u003eThough less well-studied or confirmed, emerging research suggests that DHA and EPA levels may be formative in maintaining healthy and normal moods, due to altering certain neurological proteins. These literatures require follow-up and replication, but show promise in establishing a new purpose for DHA and EPA supplementation.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-DAILY-HEALTH.jpg?v=1704444343\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/103453_Core_Multipac_Dispenser_DIE-FIN.pdf?v=1704444506\"\u003eDaily Health Pack Label \u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/REFFERENCES-HEALTH-PACK.pdf?v=1704360395\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":53256730444086,"sku":"850051031320","price":323.81,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/Daily_Healthpack_5_a8e2eb48-4761-4d92-8d8b-750631b9121f.png?v=1762807463"},{"product_id":"core-bolic-v2","title":"Bolic v2","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003eCan Increase Muscle Protein Synthesis\u003c\/li\u003e\n\u003cli\u003eMay Increase Lean Body Mass\u003c\/li\u003e\n\u003cli\u003eCan Improve Athletic Performance\u003c\/li\u003e\n\u003cli\u003eCan Boost Recovery \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eIntroducing Core BOLIC V2: Unleash Your Full Potential with Nature's Power\u003c\/p\u003e\n\u003cp\u003eIn the pursuit of peak physical performance, rapid recovery, and overall well-being, we present to you Core BOLIC V2—an innovative fusion of heavily studied ingredients meticulously crafted to elevate your capabilities. At its core are three remarkable components: PeptiStrong™, Maral Root Extract, and Camellia sinensis Extract, (fortified by the bioenhancing prowess of BioPerine®. Together, these elements unlock a world of possibilities that extend beyond the ordinary.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePeptiStrong™, hailing from fava beans (Vicia faba), takes center stage as a game-changing ingredient. It harbors a treasure trove of bioactive peptides, potent natural compounds also found in collagen, insulin, and glutathione. Patented and extensively researched, these peptides have displayed remarkable effects muscle protein synthesis, recovery, and overall muscle hypertrophy.\u003c\/li\u003e\n\u003cli\u003eMaral Root Extract, sourced from Rhaponticum carthamoides, is a revered natural ingredient renowned for its adaptogenic properties and myriad health benefits. Maral Root Extract is a game-changer for endurance, as it elevates adenosine triphosphate (ATP) production, extending exercise durations and delaying fatigue. Its ability to stimulate muscle protein synthesis, enhance muscle recovery, and improve muscular strength empowers you to achieve more during your workouts.\u003c\/li\u003e\n\u003cli\u003eCamellia sinensis Extract (Bean), standardized to an impressive 90% Epicatechin, adds another layer of excellence to Core BOLIC V2. Epicatechin shines in promoting muscle growth, strength, nitric oxide production, and overall heart and brain health. Furthermore, its nitric oxide-boosting capabilities translate to better blood flow, facilitating nutrient absorption and delivering an impressive pump during workouts.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBioPerine®, a patented extract from Piper nigrum (black pepper) enhances bioavailability as well as elevates the effectiveness of Core BOLIC V2’s ingredients by inhibiting intestinal motility and dilating blood vessels in the gut—where nutrient absorption thrives.\u003c\/p\u003e\n\u003cp\u003eSo, as you can see, Core BOLIC V2 not only increases exercise performance, but makes the underlying anabolic response (muscle growth and protein synthesis) to exercise more efficient – ensuring that your hard work is paying off!\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFava Bean (Vicia faba) Hydrolysate (as PeptiStrong™)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePeptiStrong™ is an ingredient derived from fava beans that contains extremely beneficial natural compounds called bioactive peptides. Other sources of naturally occurring bioactive peptides are collagen, insulin, and glutathione, all of which have crucially beneficial properties. These peptides have undergone patent protection and extensive research, including both pre-clinical and clinical studies. The studies have shown positive effects on gene expression and the secretion of tumor necrosis factor alpha (TNF-a). In vitro experiments using murine skeletal muscle cells and human macrophages have validated the ability of the peptides within PeptiStrong™ to increase muscle protein synthesis and reduce TNF-a secretion. The study also assessed the bioavailability and stability of the peptides, which proved to be resistant to digestion, displayed good intestinal barrier transport, and remained stable in plasma.\u003c\/p\u003e\n\u003cp\u003eIn an in vivo study using a murine model of muscle atrophy, PeptiStrong™ treatment for 18 days resulted in a significant attenuation of muscle loss and increased expression of muscle fibers. The treatment also upregulated protein-synthesis-related genes in muscle tissue. Other protein hydrolysates of fava bean and food-derived hydrolysates did not exhibit the same level of efficacy in vitro. Thus, PeptiStrong™ demonstrated efficacy in attenuating muscle atrophy through various mechanisms, including inflammation reduction and muscle protein synthesis.\u003c\/p\u003e\n\u003cp\u003eA clinical study compared the effects of PeptiStrong™ and milk protein supplementation on muscle mass and strength loss during limb immobilization. The study involved 30 young men subjected to one-legged knee immobilization followed by recovery. PeptiStrong™ supplementation performed similarly to milk protein in modulating muscle size loss during immobilization and regain during remobilization. Notably, higher muscle protein synthesis rates were observed during remobilization in the PeptiStrong™ group.\u003c\/p\u003e\n\u003cp\u003eAnother study with 30 healthy male subjects investigated the effects of PeptiStrong™ supplementation on strength recovery and fatigue. The subjects were divided into groups receiving either a placebo or 2.4 grams of PeptiStrong™ daily. Delayed onset muscle soreness (DOMS) was induced using resistance exercise, and the subjects' strength recovery and fatigue were measured over three days. PeptiStrong™ supplementation significantly improved strength recovery, reduced fatigue, and positively influenced markers associated with muscle homeostasis. Myostatin expression was also found to be significantly reduced, indicating an anabolic response following intense exercise.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMaral Root Extract (Rhaponticum carthamoides) (10:1)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMaral Root Extract, derived from the plant Rhaponticum carthamoides, is a natural ingredient highly regarded for its adaptogenic properties and numerous health benefits. This herb has a rich history in traditional medicine and is known for its ability to enhance physical and mental performance, support stress resilience, boost energy levels, promote vitality, improve athletic performance, and aid in post-exercise recovery. One crucial aspect of athletic performance is the ability to maintain a high capacity throughout the event and be able to then recover efficiently. Maral Root Extract has shown potential in addressing both of these aspects. Let's first examine how this herb can enhance measures of athletic performance.\u003c\/p\u003e\n\u003cp\u003eWhen it comes to increasing endurance, two key factors play a significant role: oxygen and adenosine triphosphate (ATP). Oxygen is essential in breaking down carbohydrates, fats, and proteins and converting them into ATP, the primary energy source for the body. Maral Root Extract has been found to increase ATP production, which can allow individuals to exercise for longer periods and delay the onset of fatigue.\u003c\/p\u003e\n\u003cp\u003eFurthermore, studies suggest that Maral Root Extract supplementation may promote greater muscle protein synthesis. While the exact mechanisms of 20-hydroxyecdysone (a plant ecdysteroid) on muscle protein synthesis are not fully elucidated, it appears to involve a rapid increase in calcium in the cell (cytosol) causing activation of Akt\/PI3K signaling. This signaling promotes the metabolism, proliferation, cell survival, growth, and angiogenesis of cells. Along with these increases in muscle protein synthesis, Maral Root Extract has also been shown to aid in muscle recovery and improve muscular strength, enabling individuals to generate more power during workouts.\u003c\/p\u003e\n\u003cp\u003eMoreover, the active compounds present in Maral Root Extract, such as ecdysteroids and additional flavonoids, exhibit potential anti-inflammatory and antioxidant effects through their adaptogenic properties. These properties can help the body adapt to physical and mental stressors and can further contribute to improved muscle recovery, reduced exercise-induced muscle damage, and faster bounce back after intense training sessions.\u003c\/p\u003e\n\u003cp\u003eAdditionally, Maral Root Extract has been found to influence hormone levels, particularly testosterone and cortisol. It can help maintain a healthy testosterone-cortisol ratio, which is beneficial for muscle growth and recovery. Achieving hormonal balance can contribute to better exercise performance and body composition.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCamellia sinensis Extract (Bean) (std. to 90% Epicatechin)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eEpicatechin is a plant-based phytochemical, or flavanol, that is found in trace amounts in foods and liquids such as dark chocolate and green tea. Its physiological benefits have been studied for years and have resulted in promising results in relation to:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eEnhanced muscle growth and strength\u003c\/li\u003e\n\u003cli\u003eIncreased nitric oxide production (better pumps)\u003c\/li\u003e\n\u003cli\u003eLowered cholesterol levels due to antioxidant content\u003c\/li\u003e\n\u003cli\u003eImprovements in brain and heart health\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThese proposed benefits listed above and the compelling research surrounding them has led epicatechin to be involved in innovations where muscle growth and improved performance are the goal.\u003c\/p\u003e\n\u003cp\u003eHow does epicatechin work? Glad you asked. The proposed mechanism of action of epicatechin is through the inhibition of myostatin, which is a type of protein called a myokine that in essence acts as a regulating molecule released by muscles. Increased levels of myostatin have been linked to limiting the level of muscle growth. To combat an increased concentration of myostatin, epicatechin can work to increase another protein called follistatin which the body can then use to control metabolism, promote muscle growth, and boost fertility. Increased myostatin has been linked to the clinically obese and inactive as well as individuals who have some degree of insulin resistance. Studies have shown that aerobic activities, strength training, and some modifications to diet can, to a degree, decrease myostatin levels in muscle. When it comes to epicatechins ability to increase follistatin levels and further inhibit myostatin concentrations as few studies have been conducted for its efficacy.\u003c\/p\u003e\n\u003cp\u003eOne study conducted on males showed that just 170mg of epicatechin per day was able to increase follistatin by about 50% and decrease myostatin by about 17%, which also coincided with an increase in strength of about 7%.\u003c\/p\u003e\n\u003cp\u003eLooking at epicatechins nitric oxide boosting benefits, one animal study showed that nitric oxide and endurance was able to be increased even in the absence of exercise. This can aid in nutrient absorption and improved heart and muscle health outside of the gym but in the gym, it can also result in greater blood flow to muscles and stimulate a better pump in response to training.\u003c\/p\u003e\n\u003cp\u003eThe literature that has been presented on epicatechin in in vivo studies on muscle growth potential and improved overall health is promising and when combined with the other ingredients in this product, the body can be set up for the most beneficial environment for muscle growth, strength increases, and increases in performance.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e Bioperine® (Piper nigrum) (Fruit) (std. to 95% Piperine):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBioPerine® is a patented standardized extract from the fruit of Piper nigrum (black pepper). It’s studied benefits have shown improvements in bioavailability of nutrients it is surrounded by.\u003c\/p\u003e\n\u003cp\u003eBioPerine® primarily works through mechanisms and channels that can inhibit intestinal motility and dilate blood vessels of the intestines (where absorption of nutrients occurs). This physiological action may cause increased absorption and digestion of nutrients.\u003c\/p\u003e\n\u003cp\u003eSeveral studies looking at the impact of BioPerine® on nutrient absorption and several plant compounds have been done. One study looking at the efficacy of BioPerine® on serum concentrations of curcumin showed bioavailability was improved by more than 500%. Therapeutic effectiveness of curcumin has often been exhibited as low. Another study conducted over the course of 6 weeks on BioPerine® influence on serum selenium levels in humans showed an increase by 145% over the presupplementation value.\u003c\/p\u003e\n\u003cp\u003eWith promising research being done on the effects of BioPerine® in the context of nutrient absorption and bioavailability, it is only fitting that we include it in Core BOLIC V2.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-BOLIC-2023.jpg?v=1696576317\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/core_BOLIC_2023_8.5x3.25-FIN.pdf?v=1696493534\"\u003eCore BOLIC Version V2 Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core_BOLIC_V2_Product_References.docx?v=1696493236\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":53256732115254,"sku":"850051031214","price":276.19,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/BOLIC_FRONT_c21c3802-624f-4c18-8e4a-e18cc5564a82.png?v=1762807468"},{"product_id":"core-liver","title":"Liver","description":"\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eMilk Thistle Extract\u003c\/strong\u003e - hepatic stress suppression\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKatuki Extract\u003c\/strong\u003e - enhances bile production\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTUDCA\u003c\/strong\u003e - enhance liver protection\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eFor many athletes, the liver isn’t the first thing that comes to mind when they think about optimizing their gains and recovery. Yet the liver has an undeniable impact on your overall health and fitness. Its actions aid in the filtering of harmful substances from the blood, production of proteins that carry hormones, drugs and fatty acids throughout the body, creates bile to breakdown fats, and stores glycogen, vitamins and other minerals for use in everyday processes. Conversely, the consistently elevated levels of muscle damage, excessive protein intake and stimulant use typical for your average weightlifter places additional stresses on the liver, leading to increased oxidative stress, liver damage and elevated markers of liver function.\u003c\/p\u003e\n\u003cp\u003eThis dynamic opposition, where liver function is essential for overall fitness and growth while the very processes involved in body recomposition can cause damage and reduce function, requires an effective remedy to aid with short term fitness goals, as well as long term liver health and function. Enter Core LIVER - our comprehensive liver support and detoxification supplement.\u003c\/p\u003e\n\u003cp\u003eWith overall liver health and function in mind, we scoured the available clinical research studies to formulate a liver supplement provides remedial support and protection through multiple metabolic pathways and mechanisms. Overall, this formula helps to provide protection against free radicals and liver damage, enhances liver function, and aids in detoxification. Don’t neglect your liver health or Core LIVER and keep living the Crush It lifestyle.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMilk Thistle Extract (Silybum marianum) (seed) (80% silymarin)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSilybum marianum, also known as milk thistle, is a medicinal thistle from the aster or daisy family that has been used in traditional medicines for many centuries for treatment of many different diseases. Many of these treatments have been to protect the liver and associated organs from damage\/further damage. There is evidence to support that milk thistle, and specifically the silymarin compound that is found within it, exhibits a mechanism of action for hepatoprotection from free radicals through antioxidant activity, enhanced protein synthesis, and possible anti-inflammatory or immunomodulating effects. These free radicals are generated through the damage to cellular membranes called lipoperoxidation. Additionally, silymarin also enhances liver glutathione production through the inhibition of hepatocyte glutathione reduction. This can further contribute to the antioxidant support and defense for the liver. Several studies have shown improvements in liver function in individuals with certain liver diseases leading to these proposed benefits. In one in vitro human study in particular, silymarin was shown to inhibit T-cell proliferation and proinflammatory cytokine secretion in a dose-dependent manner. Higher doses of silymarin were shown to specifically control hepatic inflammation responses in chronic liver diseases. It is important to note that in relation to liver diseases, milk thistle has been studied as a complimentary treatment method to traditional treatments and that it is important to live a healthy lifestyle to prevent these diseases as much as possible.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eKatuki Extract (Picrorhiza kurroa) (rhizome and root)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eKatuki, known by its botanical name Picorrhiza kurroa, comes from the Scrophulariaceae family. Picorrhiza, coming from the Greek word ‘Picroz’, means ‘bitter’ and ‘rhiza’ meaning ‘root’. This bitter quality is what katuki has been touted for its therapeutic benefits and is said to be cooling, cleansing, and possess anti-bacterial properties. Katuki has been shown to possess potent hepatoprotective and hepatostimulative properties to offer support to the overall function of the vital liver organ. Katuki offers support by stimulating the secretion of bile, which assists the liver enzymes in coming back to homeostasis. Additionally, katuki contains a compound called picroliv, or kutkin. This compound is mainly a glucoside (derived from glucose and most commonly found in plants) and is normally isolated from the roots and rhizomes of Picorrhiza kurroa for the uses to treat certain liver ailments. In rodents, picroliv has shown efficacy that can be similar to silymarin in models that have shown hepatic damage. As mentioned above, silymarin is a highly effective compound used in the controlling of hepatic inflammation which can lead to hepatic trauma. When chronic oxidative stress, toxins, and free radicals that can wreak havoc on the liver can be controlled, the function of the liver can be enhanced, thus creating a cascading sequence of related optimally functioning actions. Some of these actions include:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003ethe filtering process of the bodies blood from any poisonous substances like alcohol and other drugs.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003ethe production of a blood protein called albumin that is helpful in carrying hormones, drugs, and fatty acids throughout the body as well as aiding in the bodies blood clotting abilities following injury.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003ethe production of bile, which is essential for the breakdown and digestion of fats and transport of other waste.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eThe storage of glycogen, vitamins, and other minerals that can be used for normal everyday processes\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eSetria® Glutathione\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eGlutathione is an amino acid containing molecule of L-glutamic acid, L-cysteine, and Glycine that is particularly concentrated in the liver. The liver has a unique ability to synthesize cysteine, a glutathione precursor, from endogenous sources through the trans-sulphuration pathway or through protein breakdown and food. It is vital to many different properties and is best known for being a powerful antioxidant. It also plays a key role in the detoxification reactions in the liver and in regulation of the thiol-disulfide status of hepatocytes. The ‘glutathione system’ comprises the enzymes that synthesize glutathione within a cell as dedicated enzymes that use glutathione for its antioxidant effects. Glutathione supplementation is thought to support this pool of glutathione present in cells and thus maintain the efficacy of the entire system. This supplementation can be even more important if chronic disease is seen as “drying up” this pool of antioxidant rich compounds. Free radicals and toxins can be a byproduct of many different things such as exercising or poor physical health, eating, and daily unhealthy lifestyle activities to name a few. When these molecules overcome the body at the cellular level, this constant barrage can have negative impacts on health and overall wellness. This overabundance of oxidative stress can contribute to pathogenesis of many liver diseases, as well as exacerbate preexisting conditions. Setria® L-Glutathione provides a potent supply of antioxidants that bind these free radicals, which can help keep them from causing lasting damage. There have been some conflicting reports on whether oral glutathione supplementation was a viable way of increasing serum glutathione levels as opposed to intravenous methods. One long-term, randomized, placebo-controlled study on the effects of oral glutathione supplementation showed that dosages as low as 250mg of Setria® Glutathione were able to:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eIncrease whole blood levels of glutathione by 17%\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eIncrease levels of glutathione in erythrocytes (white blood cells) by 29%\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThis study, as well as others, shows that supplementation of glutathione and precursors to glutathione can be a reliable compliment to traditional therapies for many hepatic and hepatic related conditions.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTUDCA (Tauroursodeoxycholic Acid)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eTUDCA gets its acronym as being the taurine conjugate of ursodeoxycholic acid (UDCA), a secondary bile acid that is produced only by intestinal bacteria. UDCA was originally FDA approved for the treatment of certain cholestatic liver diseases based on its ability to protect hepatocytes (liver cells) from hydrophobic bile acids. Cholestasis occurs when bile acids get backed up in the liver and there is room for metabolism. These bile salts can be damaging to the cell membranes of nearby tissues, in particular liver tissues, and can begin to signal for cell death (apoptosis). TUDCA works through a mechanism of action that shows its ability to inhibit liver cell apoptosis by interfering with the mitochondrial pathway of cell death, inhibit oxygen-radical production, and reduce endoplasmic reticulum stress. The endoplasmic reticulum acts as a highway between the nucleus of a cell and the cytoplasm and is heavily involved in protein and lipid synthesis. Through this reduction in ER stress, TUDCA has garnered a reputation as being a beneficial remedy for a wide range or metabolic diseases, and for being a neurological protection agent. Although TUDCA has been shown to possess wide ranges of benefits, its most common and practical use has continually been seen in the ability to provide protection and overall health for the liver.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBioperine® (Black Pepper Extract) (Piper nigrum) (fruit) (std. 95% piperine)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBioPerine® is a patented standardized extract from the fruit of Piper nigrum (black pepper). It’s studied benefits have continually shown improvements in bioavailability of nutrients it is surrounded by. When it comes to post exercise nutrition, efficiency and speed with which nutrients can enter the system and get to their target is of the upmost importance. The “window of opportunity” is much larger than what has been previously thought, but when your results weigh heavily on post-exercise nutrition, maximal absorption and use of nutrients is extremely important.\u003c\/p\u003e\n\u003cp\u003eBioPerine® primarily works through mechanisms and channels that can inhibit intestinal motility and dilate blood vessels of the intestines (where absorption of nutrients occurs). This physiological action may cause increased absorption and digestion of nutrients.\u003c\/p\u003e\n\u003cp\u003eSeveral studies looking at BioPerine®’s impact on oxidative stress have been performed. One study conducted on rats in 2013 looked at the influence of piperine on rats with developed disorders such as hypertension, increased inflammatory markers, and increased plasma liver enzymes after being fed a high carbohydrate and high fat diet. The results showed that after 16 weeks of supplementation with piperine these rats experienced normalized blood pressure, improved glucose tolerance, reduced markers of oxidative stress and inflammation, and improved liver function.\u003c\/p\u003e\n\u003cp\u003eWith more promising research being done on the effects of BioPerine® in the context of nutrient absorption, bioavailability, and its influence on certain health markers, it is only fitting that we include it in Core Life Line’s Liver support product.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-LIVER.jpg?v=1634282355\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/lifeline_LIVER_8.5x3.25-FIN.pdf?v=1634206553\"\u003eLiver Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Liver_Product_References.pdf?v=1634282554\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":53256733655350,"sku":"658580070564","price":247.62,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/LIVERFRONT_9c41b667-29f5-4f38-a249-9c62fec4ef1e.png?v=1762807479"},{"product_id":"core-heart","title":"Heart","description":"\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eHawthorne Berry Extract\u003c\/strong\u003e - blood vessel antioxidant support.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBergamot\u003c\/strong\u003e - healthy cholesterol support.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eResveratrol\u003c\/strong\u003e - enhanced overall cardiovascular function\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eEvery set, rep and mile, every breath, even your thoughts - ultimately every single one is driven by your heart. As the body’s engine and delivery system, no one escapes the undeniable need for a healthy cardiovascular system. For the driven athlete - such as those living the Crush It lifestyle - the aggregation of marginal gains provided by improving your cardiovascular health promises to elevate performance throughout your fitness regimen.\u003c\/p\u003e\n\u003cp\u003eAnd yet, few list improving cardiovascular function as a key priority within their fitness goals. You see, while the heart occupies the kind of rarified air reserved for central components of only the most vital bodily systems, its function is involuntary, its improvements invisible. You don’t have to think about beating your heart, it is done for you. What’s more, a well-maintained, highly trained heart muscle won’t get you noticed at the beach.\u003c\/p\u003e\n\u003cp\u003eThat said, however, our heart is one of the most important organs in the body and communicates, assists or supports literally every other major organ system. Without an efficient blood supply, your lungs will provide less oxygen to the muscles and access to key nutrients is reduced throughout the body, resulting in less effective workouts and suboptimal recovery. So, due to our passion for fitness, as well as our desire to help our customers improve and actualize their fitness goals, we've developed a clinically backed formulation for our new premier cardiovascular health supplement: Core HEART.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eZinc (as Zinc Bisglycinate Chelate TRAACS®)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eZinc is an essential micronutrient and mineral that has been shown to affect the heart by modulation of cardiomyocyte oxidative stress and maintenance of myocardial structure. When cross sectional studies have been conducted, zinc deficiency has frequently been found to be a common link in those who have suffered heart related traumas. Myocardial tissue requires zinc in small quantities to maintain the extracellular structure formed by matrix metalloproteinases and to serve as a cofactor in free radical oxidation reactions catalyzed by superoxide dismutase (an enzyme that helps break down potentially harmful oxygen molecules in cells. When chronic inflammation is present, plasma zinc deficiency may lead to a relative deficiency in antioxidant enzymes, ultimately contributing to apoptosis and myocardial necrosis. As the lack of cardio function and zinc levels tend to decline with age, ensuring zinc optimal zinc levels can be of an importance in maintaining cardiac optimal cardiovascular function as one ages\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin K2 (as MenaQ7®, Menaquinone-7)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAdequate intake of vitamin K2 has been shown to significantly benefit cardiovascular function. Lifestyles and eating habits in the traditional western diet can often contribute to an accelerated calcium deposit in blood vessel walls and soft tissues, which can lead to dysfunctional cardiovascular health. Calcium does serve many vital roles in the human body, such as muscle contraction, nerve signaling, blood clotting properties, and blood vessel contraction and expansion. It is also recommended in a supplemental form for those individuals who are suffering from bone related declines for support. So yes, calcium is beneficial for heart health and a wide variety of bodily functions. Where calcium can become less beneficial is when it is overconsumed and renders normal calcium concentrations in the blood ineffective. So, there is evidence to show that serum levels of calcium in the upper normal range increase risk of cardiovascular function declines due to elevated blood clotting and calcium deposition in blood levels.\u003c\/p\u003e\n\u003cp\u003eEnter, vitamin K2, which specifically has been shown to inhibit this arterial calcification and arterial stiffening through its ability to activate matrix GLA protein, which inhibits calcium from forming deposits on the vessel walls. Vitamin K2 also is essential for maintaining blood homeostasis, as well as optimal bone and heart health through its role in inducing calcium use by proteins. With vitamin K2 being almost non-existent in typical diets on the western part of the world (partly due to our traditional eating habits), supplementation can be crucial to lowering risk of cardiovascular function decline. One study conducted using supplemental Vitamin K2 showed that consistent use of small doses (specifically Mena Q7) were enough to improve bone mineral density, bone strength, and cardiovascular health through the mechanisms of action listed above. The increase of calcium usage for purposes of osteoblast usage, increasing arterial elasticity, and reduction in age related arterial stiffening make vitamin K2 an essential mineral for optimal cardiovascular function and health.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin D3 (as Cholecalciferol)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVitamin D, in its various forms, is not an essential nutrient – as it is produced endogenously within the body, as a reaction to the skin’s exposure to the sun – and thus not commonly considered a vitamin. Despite its technical classification, vitamin D (a hormone), is nevertheless an import and biologically-active compound, necessary for the calcium homeostasis and metabolism, along with increasing the absorption of magnesium and phosphate.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHawthorne Berry Extract (Crataegus oxyacantha) (fruit) (4:1)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eHawthorne has been utilized for many centuries for its wide range of health benefits. One of these primary benefits is how it positively affects the cardiovascular system. The berries, or fruit, of the plant contain high amounts of bioflavonoids and proanthocyanidins, substances shown to contain most of the health promoting qualities. These antioxidants have several mechanisms of action on the cardiovascular system. Hypotensive (lowering blood pressure) improvements can be seen through vasorelaxation through the stimulation of nitric oxide production. Several studies have investigated this benefit on blood pressure as well. One human study conducted on individuals with high blood pressure showed that the administration of 1200mg of Hawthorn Berry (slightly more than what we use in this product), noticed substantial improvements in blood pressure when compared to placebo.\u003c\/p\u003e\n\u003cp\u003eHawthorne Berry can also play a role in preventing atherosclerosis, or a buildup of plaque in the blood vessels that occurs due to an imbalance in blood fat levels (typically high triglycerides and low HDL cholesterol). If this plaque continues to accumulate, it can lead to blockages in the blood vessels carrying blood to vital organs, ultimately resulting to heart attack or stroke. Anti-atherosclerotic improvements can be seen through the downregulation of capsase-3 gene expression. The capsase-3 gene is known for being a proapoptotic (cell killing) gene that has been reported in heart failure and myocardial infarction (heart attack). The regulation of lipoprotein lipase (regulates the delivery of fats to body tissues) expression and raised excretion of bile acids can also benefit the arteries. Several animal studies have examined the positive impact of Hawthorne Berries on cholesterol. One study on mice showed that mice given the extract resulted in a lower total and LDL cholesterol, as well as between 30-45% lower liver triglyceride levels compared to mice that were not administered the extract.\u003c\/p\u003e\n\u003cp\u003eOn cardiac cells, these antioxidants downregulate capsase-3 gene expression and inhibit 3’,5’-cyclic adenosine monophosphate phosphodiesterase, which can result in an increase in coronary flow, increase in relaxation velocity, and cause a positive inotropic effect (increase the strength of heart muscle contraction).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOlive Extract (Olea europaea) (leaf) 20% Oleuropein)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eOlea europaea, more commonly known as the olive, is a species of a small tree in the family Oleaceae, native to the coastal areas of southeastern Europe, western Asia and northern Africa, as well as northern Iran at the south end of the Caspian Sea. As the fruits, oils, and extracts of Olea europaea L. are a dietary component for a significant portion of the world’s population, the plant has become associated with a wide-range of physiologic and metabolic benefits. These properties are largely attributed to the phenolic compounds of olive leaves, including: caffeic acid, verbascoside, oleuropein, luteolin 7-O-glucoside, rutin, apigenin 7-Oglucoside, and luteolin 4′-O-glucoside. Collectively, these olive polyphenols are responsible for a wide-range of postulated health benefits.\u003c\/p\u003e\n\u003cp\u003eOleuropein, in particular, is purported to have several pharmacological properties including antioxidant, anti-inflammatory, anti-atherogenic, and anti-microbial effects. Research shows that olive leaf extract can benefit the heart by helping to prevent LDL cholesterol from building up in the arteries. This process can increase blood flow and lower blood pressure, which can thus reduce the risk of heart disease.\u003c\/p\u003e\n\u003cp\u003eRed Yeast Rice (Monascus purpureus)\u003c\/p\u003e\n\u003cp\u003eRed yeast rice is traditional Asian preparation of the rice grain with an extensive history dating back to 300 BC. The rice is fermented in a culture of yeast called Monascus purpureus, which transfers in bright red coloration to the white rice grains. In part due to its centuries of use in traditional Chinese medicine, red yeast rice is widely recommended in regimens intended to help establish normal cardiac function and lipid profiles.\u003c\/p\u003e\n\u003cp\u003eMore recent studies suggest the fungal metabolites found within red yeast rice demonstrate a positive impact on cholesterol and cardiac function. Specifically, a fungal secondary metabolite found within red yeast rice, known as monacolin K, has been shown to of particular interest. The primary mechanism of action of monacolin K is inhibition of the key enzyme, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, involved in cholesterol synthesis. Upon further evaluation of the lipid lowering properties of red yeast rice, recent research revealed them to be multifactorial, including the ability to downregulate the rate limiting step of hepatic cholesterol biosynthesis in a dose-dependent manner, indirectly cause an upregulation or availability of LDL-receptors in the liver, and possibly increase the hepatic excretion of bile acids, thereby creating an increased need for the availability of intrahepatic cholesterol for use in the synthesis of additional bile. The reduced intrahepatic cholesterol concentrations result in the upregulation or availability of LDL-receptors in the liver. The purpose of these additional LDL-receptors is to pull cholesterol out of circulation and bring it into the liver as a replacement for the reduced production inside the liver. When this happens, the plasma cholesterol levels will decrease through a reduction in the hepatic synthesis of cholesterol and through an increase in the removal of circulating cholesterol from blood plasma into the liver for use. These actions can help restore cholesterol levels to where they benefit cardiac and other bodily function.\u003cstrong\u003e Note: If you are taking other statins or other cholesterol lowering medication, please consult with your physician prior to supplementing with Core HEART.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBergamot Fruit Extract (Citrus aurantium bergamia) (30% Polyphenols)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBergamot, a citrus fruit native to southern Italy, has often been used to improve immunity and cardiovascular function. These benefits have been traced back to the phytochemicals and flavonoids that are contained within bergamot. Multiple studies have been conducted to show the efficacy of orally administered bergamot on reductions in total cholesterol and LDL cholesterol 1, where the end goal is the restoration of overall cardiovascular function and vessel health. The primary mechanism of action for the therapeutic phytochemicals found within bergamot is the inhibition of oxidation of low-density lipoprotein particles. When oxidation occurs to LDL particles, it produces a harmful form of cholesterol because of the damage caused by free radicals. This oxidative damage has been specifically linked to altered cardiovascular blood flow and cardiovascular vessel diseases. Phytochemicals such as naringin, neoeriocitrin, and rutin have been shown in vitro to possess antioxidant properties and ability to lower the oxidation of LDL particles.\u003c\/p\u003e\n\u003cp\u003eIn addition to the animal studies, several human trials have been conducted analyzing the benefits of bergamots. One 2011 randomized, double blind, placebo controlled clinical trial looked at the impact of bergamot administration for 90 days on total cholesterol, LDL levels, and HDL levels in patients. The results showed that 500mg of bergamot reduced total cholesterol (20%) and LDL (23%), while increasing HDL levels (26%). This is just one example but results of other studies show promise in bergamot’s cholesterol improving benefits as well as optimizing overall cardiovascular function.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCurcumin (Curcuma longa) (root) (95% Curcuminoids)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eTurmeric is a root endemic to certain regions of Southeast Asia and India, and has been a staple in the Siddha traditional medicinal system for thousands of years. Turmeric is noted in Siddha texts for various uses, including as an ancient equivalent of an anti-microbial agent.\u003c\/p\u003e\n\u003cp\u003eMore recently, numerous studies seem to suggest that its primary bioactive constituent, curcumin, powerfully inhibits the enzymes that synthesize inflammatory compounds such as prostaglandins and leukotrienes. In particular, basic research and molecular studies have now firmly established curcumin’s ability to dose-dependently and potently inhibit a transcription factor known as NF–kB – a molecule involved in the proliferation of pro-inflammatory cytokines, soft tissue destruction, and autoimmune responses.\u003c\/p\u003e\n\u003cp\u003eThough turmeric contains approximately 5% curcumin by weight, we have used a highly standardized extract of 95% - recognizing that the wealth of research on curcumin demands that it be included in clinical serving sizes.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePolygonum cuspidatum Extract (root) (50% trans-Resveratrol)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eResveratrol is a polyphenolic stilbene produced by various plants. Trace amounts of resveratrol can be obtained from certain foods but the clinical doses used for studies involving cardiovascular function are at much higher concentrations than can be likely received through dietary means. While the half life of resveratrol is relatively low (4-8 hours) after oral administration, a large number of animal studies have shown beneficial effects for cardiovascular function. The specific mechanisms of action for resveratrol are somewhat unclear, but studies have shown many positive benefits tracing back to decreases in oxidative stress response, increases in endothelial function, leading to more efficient diastolic function, cardiac remodeling, myocardial energetics, and vascular function. The proposed mechanism for the inflammation mediating effects can be brought back to an increased activation of the silent information regulator factor 2 related enzyme 1 (SIRT1). SIRT1 has been shown to protect against cardiac decline related inflammation. When studied, cells from mice with a SIRT1 knockout have shown increased pro-inflammatory cytokine levels. With resveratrol being a known activator of SIRT1 in animals, it is led to believe that the same mechanism can be beneficial in humans. This mechanism, along with other benefits on blood pressure (increased NO production), make resveratrol a valuable compound in establishing normal cardiac function and baselines of cardiac health.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCoenzyme Q10 (Ubidecarenone)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCoenzyme Q10, which is synthesized in the mitochondrial inner membrane, is an essential compound that plays many vital roles in the human body. Of these many roles, it is a key component in the electron transport chain in mitochondria necessary for ATP production. CoQ10 can also act as an intercellular antioxidant, protecting the plasmatic membrane against peroxidation. CoQ10 deficiency has been associated with less-than-optimal health status in organisms and has contributed to certain degenerative states involving blood sugar, the cardiovascular system, and musculoskeletal system. In relation to the cardiovascular system, oxidative stress is one of the main causes of cardiac decline. The antioxidant properties of CoQ10 are of particular importance in establishing normal function. It has been shown that individuals suffering from cardiac related abnormalities have significantly lower levels of CoQ10 as opposed to those with higher levels. With antioxidant effect and free radical neutralization being the primary mechanism of action, CoQ10 exhibits a secondary mechanism of action of well in playing a large role in the heart’s energetic needs. The process of cardiac contraction requires the release of Ca2+ from the SR and the following activation of the contractile proteins requires energy. It is believed that when there is myocardial failure, it is caused by a reduction in the production of energy from the mitochondria. This goes back to CoQ10s property of being a main component in the transport of electrons that are needed for ATP production. These two mechanisms of action have a particular importance for one’s quality of life as well as in maintaining proper cardiovascular function.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBioperine® (Black Pepper Extract) (std. to 95% Piperine)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBioPerine® is a patented standardized extract from the fruit of Piper nigrum (black pepper). It’s studied benefits have shown improvements in bioavailability of nutrients it is surrounded by. In this specific product for Core HEART, it is included because it dramatically increases the bioavailability of curcuminoids (see above). Without Bioperine, the serum concentration and absorption rates of the active agents in curcumin would be significantly reduced.\u003c\/p\u003e\n\u003cp\u003eBioPerine® primarily works through mechanisms and channels that can inhibit intestinal motility and dilate blood vessels of the intestines (where absorption of nutrients occurs). This physiological action may cause increased absorption and digestion of nutrients.\u003c\/p\u003e\n\u003cp\u003eSeveral studies looking at the impact of BioPerine® on nutrient absorption have been done. One study looking at the efficacy of BioPerine® on serum concentrations of curcumin showed bioavailability was improved by more than 500%. Therapeutic effectiveness of curcumin has often been exhibited as low. Another study conducted over the course of 6 weeks on BioPerine® influence on serum selenium levels in humans showed an increase by 145% over the presupplementation value.\u003c\/p\u003e\n\u003cp\u003eWith promising research being done on the effects of BioPerine® in the context of nutrient absorption and bioavailability, it is only fitting that we include it in Core HEART.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-HEART.jpg?v=1634282355\"\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/lifeline_HEART_8.5x3.25_FIN-OL.pdf?v=1634206628\"\u003eHEART Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Heart_Product_References_1.pdf?v=1634282698\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":53256733688118,"sku":"658580070502","price":247.62,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/HEARTFRONT_b3f69a8b-6247-470b-a6a8-1950385800c6.png?v=1762807480"},{"product_id":"core-prostate","title":"Prostate","description":"\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eSaw Palmetto Extract\u003c\/strong\u003e - aims to maintain healthy prostate size.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStinging Nettle Extract\u003c\/strong\u003e - normal and healthy urinary flow and frequency.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLycopene\u003c\/strong\u003e - contributes to normal prostate function.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003ciframe src=\"https:\/\/www.youtube.com\/embed\/6OtivPyiieo\" width=\"560\" height=\"315\"\u003e\u003c\/iframe\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan data-contrast=\"none\"\u003eFrom an early age, men are taught to associate their virility, potency, and vigor with their sense of masculinity. Yet, as we age, the vital systems and metabolic pathways that help us maintain that virility slowly begin to decline. For some, this is an unavoidable part of aging that should be handled with grace and acceptance. For others, such as those living the Crush It lifestyle, this akin to meekly accepting defeat when other options are available. You see, it is critical to maintain a healthy, normal prostate function. While aging makes maintaining this function increasingly difficult, there are robust supplement regimens that can assist in promoting proper prostate health and function. \u003c\/span\u003e\u003cspan data-ccp-props='{\"201341983\":0,\"335559739\":160,\"335559740\":259}'\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan data-contrast=\"none\"\u003eWhile many supplements singularly focus on an individual ingredient, this oversimplified single ingredient approach ignores the complexity of this multi-faceted issue – an issue that undoubtedly requires a multi-faceted solution. So, in line with the product development philosophy we’ve maintained at Core Nutritionals since our inception, we’ve elevated a product category and delivered a comprehensive prostate health formula suitable to such a complex and significant issue. By scouring the available clinical research, we’ve found a veritable constellation of ingredients that address every major pathway involved in the promotion of a healthy prostate. And, with that, we give you the premier solution for maintaining an optimal functioning prostate: Core PROSTATE! \u003c\/span\u003e\u003cspan data-ccp-props='{\"201341983\":0,\"335559739\":160,\"335559740\":259}'\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePumpkin Seed Oil Powder (Cucurbita pepo)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePumpkin seed has been used in the medical treatment realm for decades, especially for its noted benefits towards prostate health improvement. The fatty acids contained in pumpkin seeds, especially delta-7-sterols, tocopherols, and other micronutrients have shown specific promise in optimizing normal prostate function. A 2014 randomized, double-blind, placebo-controlled study looked at the effects of different administrations on subjects. Subjects were split and received either sweet potato starch, pumpkin seed oil, saw palmetto oil, and pumpkin seed oil with saw palmetto oil. What the results showed was that the group given pumpkin seed oil noticed improvements in quality of life and improvements in maximal urinary flow. These same improvements were also shown in the combined pumpkin seed oil and saw palmetto oil group making them both reputable complimentary products that can benefit the health of the prostate.\u003c\/p\u003e\n\u003cp\u003eOne of the primary mechanisms of action for pumpkin seeds is to block the conversion of testosterone to dihydrotestosterone, inhibiting the enzyme 5-α-reductase. Dihydrotestosterone is classified as a powerful metabolite of testosterone with critical functions as an androgen. While androgens can be beneficial for men, when they get too high, they can negatively affect certain parts of the human body, including the prostate, leading to issues such as less than optimal prostate function. Maintaining normal levels of dihydrotestosterone in the prostate is therefore a paramount property to maintaining the normal function of the prostate.\u003c\/p\u003e\n\u003cp\u003eZinc is also critical to normal prostate function. In fact, a normal functioning prostate has the highest levels of zinc in the body. A 2011 human study found an increase in urinary zinc excretion. Pumpkin seeds are naturally high in zinc, leading to their consumption could be beneficial to extract their prostate health improving properties.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSaw Palmetto Extract (Serenoa repens) (fruit) (85% Total Fatty Acids)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSaw Palmetto is a traditional herb that grows in the Southern coastal regions of the United States that has been often used to maintain normal, healthy prostate function. Growth of the prostate is believed to happen through the action of 5α-reductase, which catalyzes the conversion of testosterone to dihydrotestosterone. Dihydrotestosterone binds to nuclear androgen receptors and activates the transcription of androgen-regulated genes that are mitogenic to both epithelial and stromal cells. Due to the fact that the development and growth of the prostate gland depend on androgen stimulation, the mechanisms of action of saw palmetto include several antiandrogenic effects, such as inhibition of 5α-reductase I and II and inhibition of binding of dihydrotestosterone (DHT) to the cytosolic androgen receptors, anti-proliferative effects and anti-inflammatory effects. Several studies have shown that saw palmetto, and the mechanisms of action listed above may positively influence the prostate by helping to maintain its optimal size and function, which then equates to a healthy urinary flow and frequency.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStinging Nettle Extract (Urtica dioica) (root) (20:1)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eStinging nettle has been widely used is traditional medicine for its benefits as a diuretic and to treat things like joint pain, eczema, arthritis, gout, and anemia. More recently, stinging nettle has been utilized for the purpose of maintaining normal urinary flow and contributing to a healthy, optimal functioning prostate. Stinging nettle has also showed effectiveness when used in combination with other herbs, like saw palmetto (above). Human studies have shown this effectiveness in these areas, like urinary flow maintenance, through their specific mechanisms of action, which were discussed in the paragraph above. The mechanism of action for stinging nettle is still somewhat unclear but it seems likely that sex hormone binding globulin (SHBG), aromatase (the key enzyme in estrogen biosynthesis), epidermal growth factor and prostate steroid membrane receptors are involved in the anti-prostatic effect. While the mechanism of action may be unclear at the present moment, the success of stinging nettle in human studies makes it a promising application for maintaining normal prostate health and function.\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cp\u003eInduce G1\/S arrest of the cell cycle\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003eInduce apoptosis\u003c\/li\u003e\n\u003cli\u003eInhibit angiogenesis Regulate sex hormones and\u003c\/li\u003e\n\u003cli\u003eIncrease antioxidant activity\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003ePygeum Bark Extract (Pygeum africanum) (3% Phytosterols)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe bark of Pygeum africanum, also known as the African prune tree native to tropical Africa, is a compound that has often been utilized for its benefits in maintaining prostate health. The mechanism of action for pygeum remains somewhat unclear. Studies utilizing pygeum bark have also shown promise in their benefits in support the maintenance of prostate health both in vitro and in vivo. In one in vitro study in particular, results showed that pygeum bark extract was able to inhibit the growth of PC-3 and LNCaP cells, as well as induce apoptosis and altered cell kinetics, and downregulated ERalpha and PKC-alpha protein. In vivo, utilizing TRAMP mice, the application of pygeum bark extract showed a significant reduction (35%) in prostate cancer incidence compared to mice fed another substance. Another analysis looking at 18 randomized controlled trials looked at the how pygeum africanum benefitted men and prostate health. Pygeum was shown to provide a large improvement in urinary function and flow measures when compared to other men in the study not administered pygeum. Men using pygeum africanum also noticed nocturia was reduced by 19%, residual volume of urine reduced by 24%, and peak urine flow increased by 23%. These results leave pygeum administration as a potentially beneficial application for those looking to maintain normal prostate function.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBeta-Sitosterol (40%)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eβ-sitosterol is the most abundant plant sterol in the human diet and is also the major component of several traditional medicines, including saw palmetto and devil’s claw. It is believed to help maintain prostate function by aiding in the and ease of urinary flow. A few studies have been conducted on BS effectiveness on urinary system function and flow with promising results. One randomized placebo-controlled study on men showed promising results on these issues. Results revealed that men administered β-sitosterol noticed a more efficient flow measure and increased prostate function. While β-sitosterol can benefit from more studies, the current studies show promise and ability to work in synergy with the other components of Core’s comprehensive prostate funtion formula.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eLycopene (Lycopersicon esculentum) (fruit)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eLycopene, a carotenoid found largely in tomato, pink grapefruit, and watermelon, is a natural and effective nutrient that has been able to show ability in supporting optimal prostate function. Several studies have been conducted showing lycopene’s effectiveness in maintaining this prostate function in both in-vivo and in-vitro conditions. Results of these studies showed that lycopene was able to inhibit prostatic IGF-I signaling, IL-6 expression, and androgen signaling. Lycopene was also able to show improvements in gap-junctional communication and oxidative defense genes, which can be essential for maintaining prostate function.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBoron (as Albion® Boroganic Glycine)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBoron is a mineral present in multiple fruits, vegetables, tubers, and drinking water, though it is not widely accepted as either an essential mineral or essential vitamin. Boron affects a few physiological functions in the body, particularly modulating hormonal homeostasis.\u003c\/p\u003e\n\u003cp\u003eWhile still emerging, recent data suggest that boron may play a role in potentiating free testosterone levels in healthy men. In one study, otherwise healthy men were provided an acute serving of boron and had their free and total levels of testosterone, alone with SHBG (sex hormone binding globulin) and DHT (dihydrotestosterone) levels measured. In that study, total testosterone was unaltered, but free testosterone was enhanced by 14%, while SHBG was significantly (9%) reduced. Boron has also shown substantial evidence in playing a role in supporting normal prostate function, specifically through lowering PSA (prostate specific antigen), which can be a marker for prostate abnormality advancement. Other studies have shown the effectiveness of adequate boron levels on optimizing prostate health. One human study concluded that men who ingested the greatest amount of boron in their diet were 54% less likely to be at risk of prostate related issues when compared to the lowest intake.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-PROSTATE.jpg?v=1633679693\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/lifeline_PROSTATE_8.5x3.25-FIN.pdf?v=1633427276\"\u003eProstate Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/REFFERENCES-Prostate.pdf?v=1633428194\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":53256733786422,"sku":"658580070571","price":247.62,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/PROSTATEFRONT_efa09470-b433-4b4e-a4a0-c04d8f3894bc.png?v=1762807482"},{"product_id":"gut","title":"Gut","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eCore Probiotic Blend™\u003c\/strong\u003e - Custom formulated blend of live organisms to provide the gut with beneficial bacterial support.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCore Biome® Tributryin\u003c\/strong\u003e - Postbiotic that aids in the body's inflammatory response and stimulating growth of new cells\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSunFiber®\u003c\/strong\u003e - Prebiotic fiber that can help increase the absorption of important macronutrients and vital minerals\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003ciframe src=\"https:\/\/www.youtube.com\/embed\/1gxM3sSUwQ0\" width=\"560\" height=\"315\"\u003e\u003c\/iframe\u003e\u003c\/p\u003e\n\u003cp\u003eThe gut, or gastrointestinal (GI) tract is one of the largest systems responsible for keeping our body in working order. Food and a wide variety of nutrients pass through the separate parts, being broken down and absorbed only to be shuttled to their final destination to begin to do their job. In addition to this food, countless numbers of microorganisms from the environment pass through the gut – some of which may be detrimental to health and alter the integrity of the GI tract. Core GUT was formulated to provide all around GI tract support with beneficial bacteria in a custom probiotic blend, a useable form of food for these microorganisms in a prebiotic, beneficial by-products in a post biotic, and digestive enzymes to aid in the breakdown of crucial nutrients. This combination of ingredients has been shown to support the growth of healthy gut bacteria*, enhance immune function*, provide support for gut lining integrity*, and display protective effects on gut environment*.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBifidobacterium 8.5 billion CFU\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBifidobacterium are labeled as probiotics and normally live in the intestines and stomach. They are essential for helping your body perform essential functions such as digestion and fighting off harmful bacteria. There are a wide range of Bifidobacterium as well so we will outline each individually below.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBifidobacterium breve (2 billion CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eOne of the most helpful probiotic bacteria in the human body. Widely used probiotic strain for pediatrics. Is widely present in the gut of breast-fed infants and is known to protect against human pathogens. Some other functions of B. breve are to ferment sugars, and to product lactic acid and acetic acid. Healthy amounts of this strain can improve gut related issues such as diarrhea, gas, allergies, and irritable bowel syndrome (IBS)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eBifidobacterium infantis (2 billion CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eThis specific probiotic strain that is often used to alleviate irritable bowel syndrome as well as general abdominal discomfort and bloating.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eBifidobacterium bifidum (2 billion CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eBifidobacterium bifidum has shown promise in improving irritable bowel syndrome (IBS) constipation, lung infections, ulcerative colitis, diarrhea, and certain intestinal infections. One human study in 2011 on the benefits towards IBS showed that significant relief was reported with the administration of B. bifidum when placed against placebo. You can find this specific bacterium in foods like yogurt with added cultures, kefir, buttermilk, cured meats, sourdough bread, and sauerkraut.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eBifidobacterium longum (2 billion CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eBifidobacterium longum is classified as a multifunctional probiotic strain that has been shown to be highly effective in alleviating GI distress, immunological and infectious diseases. These benefits have been shown to be attributed to its ability to stabilize the gut microbiota and improve the overall intestinal environment.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eBifidobacterium lactis (500 million CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eLactic acid bacteria are among the most populated microflora that live within the human large intestine. They are believed to be play an integral role in the homeostasis of the gut microbiome as well as are highly beneficial for overall health. This specific Bifidobacterium can be found in many yogurts, cheeses, and other fermented dairy products and can possess benefits ranging from improved digestion, increased uptake of dietary minerals, reduction in cholesterol, as well as improvements in natural immunity.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eLactobacillus 16.5 billion CFU\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAs arguably the most common probiotic group, Lactobacillus can aid the body in the breakdown of foods, absorption of key nutrients, and defend against destructive organisms that can cause distress and other diseases.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eLactobacillus acidophilus (4 billion CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eOne of the most common probiotic types that can be most commonly found in many fermented foods, and added to yogurts, and cheeses. This type of bacteria is found in the intestines and plays a vital role in boosting human health. This bacterium helps produce lactic acid. It goes through a process of producing an enzyme called lactase, which helps break down lactose into lactic acid. This bacterium has been extensively studied for its benefits of alleviating symptoms pertaining to IBS, diarrhea, bloating, and other GI distress.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eLactobacillus plantarum (2 billion CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eL. plantarum has a significant importance on boosting antioxidant activity as well as helping maintain intestinal permeability. It can work to suppress the growth of bacteria that produce gases in the intestines as well as benefit some who suffer from IBS.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eLactobacillus bulgaricus (2 billion CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eL. bulgaricus has been used mostly as a probiotic to help aid in the improvements of digestion, prevent diarrhea, and to relieve symptoms associated with IBS. Alongside L. acidophilus it has the potential to work by helping the body maintain normal consistency of the bacteria living in the stomach and intestines.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eLactobacillus casei (2 billion CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eNaturally found in the gut as well as some fermented foods, L. casei has been shown to positively regulate our digestive system by contributing to the reduction of diarrhea. It can also positively impact constipation, Crohn’s disease, inflammatory bowel disease (IBD), IBS, lactose intolerance, and ulcerative colitis.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eLactobacillus rhamnosus (2 billion CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eL. rhamnosus is able to promote immune-responsiveness by reducing the expression of several activation and inflammation markers on monocytes and by increasing the production of interleukin in macrophages. It produces a biofilm that can protect the mucosa and also produces soluble fibers that are beneficial to the gut.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eLactobacillus brevis (2 billion CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eL. brevis is a type of lactic acid bacteria found in milk-based products, fermented products, and in some plants as they decompose. Its benefits include alleviating diarrhea related symptoms in children and supporting natural killer (NK) cell activity in older individuals. These NK cells are a type of pathogen-killing cell that can fight off infections and stop the growth of cancerous cells.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eLactobacillus gasseri (500 million CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eL. gasseri is a unique strain of bacteria commonly found in the genital, urinary, and digestive systems of the body. It possesses many benefits but it has shown particular promise in aiding positive changes in weight and improvements in body composition. It has also shown promise in reducing blood and liver cholesterol, and reducing oxidative stress in the body. These benefits are most likely attributed from reduced inflammatory status present in adipose tissue.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eLactobacillus fermentum (500 million CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eL. fermentum has been reported to enhance immunologic response as well as prevent community-acquired GI and upper respiratory infections. This specific strain of Lactobacillus also produces potent antimicrobial peptides, which can then be used as a food preservative or as alternatives in antibiotics. It has been studied to provide the benefit of decreasing cholesterol levels in the blood stream and to potentially prevent alcoholic liver disease and colorectal cancer in humans.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eLactobacillus reuteri (500 million CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eThis well studied strain of Lactobacillus can colonize a large number of mammals and provide essential benefits. Found in the GI tract, urinary tract, skin, and breast milk, the benefits of this strain include the production of antimicrobial molecules that can inhibit the colonization of pathogenic microbes and strengthen the microbiota composition of its host. Other benefits include enhancing the immune system through the production of pro-inflammatory cytokines while promoting regulatory T-cell development and function, as well as strengthening the intestinal barrier. These T-cells help maintain intestinal homeostasis by controlling inflammation and inducing tolerance.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eLactobacillus paracasei (500 million CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eAs a potent strain with immune modulation properties, several studies have shown that L. paracasei can provide relief from inflammatory bowel disease as well as alleviate inflammatory symptoms associated with colitis and other colon related issues.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eLactobacillus salivarius (500 million CFU)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eThis probiotic species is widely found in the GI tract of mammals and has been shown to possess benefits that include relief from IBS related symptoms, pancreatic necrosis, and atopic dermatitis. Many of these benefits come from the species ability to suppress pro-inflammatory cytokines and bacterial overgrowth in the small intestine, which leads to reduced bacterial translocation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eSaccharomyces 5 billion CFU\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSaccharomyces boulardii (5 billion CFU)\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eS. boulardii is a specific type of probiotic yeast that has been shown to possess benefits for human gastrointestinal health. The probiotic benefits of this organism include fighting against toxins and other harmful bacteria, increasing the function of the gut biome, providing inflammation relief for the gut lining to improve efficiency, boosting immune function, and helping to restore optimal nutrient levels, like short chain fatty acid production, for the gut. Some of the conditions that S. boulardii protects against are IBS, Crohn’s disease, Ulcerative colitis, and C. diff infections.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eTributyrin (as Core Biome™ 30% yielding 300mg)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe gut microbiome is responsible for contributions that maintain intestinal balance. Disturbances in this homeostasis can cause alterations in the metabolic and fermentation byproducts that occur in the gut. With the gut being so closely tied to many bodily processes involving many of the body’s vital systems, optimal gut health is of importance. The microbiota of the gut ferment undigested sugars to product short-chain fatty acids such as, acetate, propionate, and butyrate. Butyrate is especially essential as it has mechanisms of action that include effects of suppressing inflammation and immunoprotection, serving as the primary nutrient that provides energy to colonocytes, and regulating functions of gene expression, gut tissue development, oxidative stress reduction, and diarrhea control. When butyrate is depleted or scarce, GI distress and other injury can occur.\u003c\/p\u003e\n\u003cp\u003eSeveral studies have looked at the effectiveness of supplemental tributyrin on the benefits of gut health and have shown promising results. One animal study combining tributyrin with essential oils concluded that this combination improved the intestinal morphological structure and positively altered the intestinal microbiota and metabolites that benefit gut health. Another animal study analyzing parameters for growth as it pertains to performance of the gut microbiota concluded that, with the addition of tributyrin, there was an enhanced potential for energy metabolism and indicated that tributyrin can promote changes in the gut microbial communities. These positive changes seen can contribute to improving animal performance after weaning from an infant diet to an adult diet.\u003c\/p\u003e\n\u003cp\u003eSeveral human studies have also looked at tributyrin’s positive role on the body. Most of these studies have involved tumors of some sort, but this does provide promise to the potential benefits it can have when tumors are not present as increases in immunoprotection can beneficial for everyone. One human study showed that tributyrin was able to be cytostatic to cancer cells and induce differentiation and apoptosis (cell death) to colon cancer cells through the stimulation of interleukin-2 and -12 (2 cytokine signaling molecules in the immune system).\u003c\/p\u003e\n\u003cp\u003eWhile more studies can be beneficial for solidifying tributyrin’s benefits on gut health, these current studies do show its ability to provide immunoprotection and boost the overall function of the vital gut microbiome. CoreBiome® has been clinically proven to be a highly bioavailable source of this vital nutrient.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSunfiber® Guar Fiber\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSunfiber®, a fermented, dietary fiber, is a proven prebiotic fiber that increases both Bifidobacteria and Lactobacillus levels with the aim of providing digestive support. These beneficial bacteria promote a healthy gut microbiota and aim to enhance the overall function of the gut, thus leading to increased function of the other vital systems of the human body. Fermentation of Sunfiber® by the gut microbiome results in production of short-chain fatty acids such as butyrate, which as we discussed above, provides valuable energy for the digestive tract. The other benefits of this prebiotic include increasing the absorption of important macronutrients and vital minerals, increasing satiety and appetite control, regulating blood glucose levels, improving IBS related symptoms, and providing stool regularity.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDigestive Enzyme Blend (Protease, Lactase, Amylase, Lipase)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eOne can easily make the argument that dietary enzymes – and in particular, digestive enzymes – are the most consistently underrated and overlooked component to a supplementation regimen. These powerful little protein structures influence or outright control a vast, complex network of bodily functions. In a fitness-specific context, digestive enzymes play an absolutely crucial role in the breaking down of dietary carbohydrates, fats, and proteins into their constitutive parts, and therefore allow your body to use them in various processes (glycogenesis, protein synthesis, etc).\u003c\/p\u003e\n\u003cp\u003eDespite their critical function, many supplement companies overlook the necessity of digestive enzymes and do not include sufficient levels (and kinds) of enzymes in their products.\u003c\/p\u003e\n\u003cp\u003eAs usual, we take a much more comprehensive, clinical approach than the average. In Core Life Line’s Gut product, we have included a digestive enzyme blend comprised by:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eProteases- breaks down proteins and other peptides\u003c\/li\u003e\n\u003cli\u003eLactases- breaks down lactose\u003c\/li\u003e\n\u003cli\u003eAmylases- breaks down starches into useable sugars, such as glucose and maltose\u003c\/li\u003e\n\u003cli\u003eLipases- breaks down fats\/lipids which allow for a full and complete breakdown of all of your daily dietary components.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-GUT.jpg?v=1633098262\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/lifeline_GUT_8.5x3.25-FIN.pdf?v=1632991200\"\u003eGUT Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/REFFERENCES-GUT.pdf?v=1632991495\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":53256733851958,"sku":"658580070557","price":247.62,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/GUTFRONT_a55aab87-17f7-4f0b-bc75-fc7037d593d3.png?v=1762807483"},{"product_id":"calcium-magnesium","title":"Calcium Magnesium","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003eSupport the growth and function of bones, muscles, nerves, and heart.\u003c\/li\u003e\n\u003cli\u003eAct as a catalyst for over 300 ezymatic reactions in the body.\u003c\/li\u003e\n\u003cli\u003eWork synergistally to support normal bodily function.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eCalcium is likely one of the first nutrients ever consumed by an individual. From the time you were born, calcium was likely introduced for its benefits of bone growth, muscle and nerve function, as well as heart function. As we age, the importance of calcium is also important as the need shifts from growth to maintenance of optimal function. If optimal calcium levels are not met, whether it be in childhood or adulthood the risk of deficiency can lead to less than optimal function and quality of life later on.\u003c\/p\u003e\n\u003cp\u003eMagnesium also plays a role in similar functions of muscle and nerve function, protein synthesis, and bone integrity, as well as being a catalyst for over 300 enzymatic reactions that regulate certain physiological functions in the human body. While magnesium is an essential nutrient, our bodies must receive it from either foods or supplementation. Supplementation can help ensure optimal levels are being met to maintain optimal bodily function. These can include bone and muscle integrity as well as digestion and ability for relaxation and recovery to take place.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eThese two nutrients are essential on their own but they also work well together. It is important to note that their ratio between each other is important so there is not a competition between them. Core's Calcium\/Magnesium Citrate Commoditiy supplies the perfect ratio of calcium to magnesium for the body to maintain optimal functioning.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCalcium\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWhile best-known as the main bioactive in milk, and a compound that contributes to strong bones, calcium has numerous physiological effects in the body – including mediating vascular contraction and vasodilatation, muscle function, nerve transmission, intracellular signaling, and hormonal secretion. Homeostatic regulation of calcium, which the body cannot produce, requires sufficient levels of vitamin D, which can also be found in Core Nutritionals Commodity line of products.\u003c\/p\u003e\n\u003cp\u003eWhen present in sufficient amounts, calcium is necessary for the adequate formation, function, and remodeling of both bone and teeth. Insufficient levels of calcium are associated with degenerative bone and joint disorders such as osteoporosis, wherein osteoblast (growth) slows or stops; thereby reducing bone mass and density and decreasing bone strength.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMagnesium Citrate\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIt is difficult to overstate the biological necessity of magnesium. Magnesium is a co-factor in over 300 enzymatic reactions that regulate essential physiological functions such as protein synthesis, bone integrity, glucose homeostasis, muscle and nerve function, and the maintenance and support of healthy blood pressure levels.\u003c\/p\u003e\n\u003cp\u003eMagnesium is also required for the use of the body’s energy currency, ATP. To become biologically active, ATP must be bound to magnesium to form Mg-ATP. In addition, magnesium is necessary for the proper function of cells with calcium and potassium gated ion channels such as heart and muscle cells.\u003c\/p\u003e\n\u003cp\u003eMagnesium itself is an essential nutrient. However, our bodies cannot produce magnesium on their own, so it must be obtained from food or in supplemental means. Magnesium citrate has a role of aiding in the maintenance of healthy magnesium levels, so with most of the body’s magnesium found within bones, muscles, and in non-muscular soft tissue, maintaining normal levels is vital to these structures’ integrity. In addition to these benefits, magnesium citrate can also benefit gastrointestinal distress through its ability to relieve constipation, gas, and bloating, thus establishing normal digestive processes.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCalcium and Magnesium in Combination\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWe have talked about Calcium and Magnesium for their separate benefits towards optimal health but why are they essential to be taken together?\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCalcium,\u003c\/strong\u003e as we discussed is the most abundant mineral found in the body and most of it is found in our skeletal system and is essential for the structural maintenance of the entire skeletal system. Adequate amounts of calcium in your diet can help reduce bone loss by 30 - 50 percent.\u003c\/p\u003e\n\u003cp\u003eThere are many forms of calcium that can be made available in a supplemental form. However, in order to be effective, calcium must be properly absorbed by the body. Chelated forms of calcium (calcium citrate, which is in this product) are going to be more effective due to its increased bioavailability for the body. For maximum absorption, calcium is best taken with a meal.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMagnesium,\u003c\/strong\u003e as we also discussed is a mineral that plays an important role in maintaining healthy bones, muscle function, and nerve function. It contributes to increased bone density and helps prevent the onset of osteoporosis.\u003c\/p\u003e\n\u003cp\u003eSince magnesium works closely with calcium, it is important to have an appropriate ratio of both minerals in order for them to be effective. A good rule of thumb is a 2:1 calcium-to-magnesium ratio. For example, if you take 1000mg of calcium, you should also take 500mg of magnesium (which is what is used in this product). If this ratio is off, there can be an internal competition for intestinal absorption between these two minerals, and their effects can be diminished. This has been seen in studies especially when calcium intake is much higher than magnesium. This can be important information, as the typical diet of most people often shows calcium consumption to be much higher than magnesium. Understanding this importance of balance between these two minerals can be necessary for maintaining optimal physiological function.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-CALCIUM.jpg?v=1629733128\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Calcium_Magnesium_2020_8.5x3.25-FIN-P65_4fde88b8-7913-4d66-8ac7-b888a4fee049.pdf?v=1644226614\"\u003eCalcium Magnesium Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Calcium-Magnesium-Citrate-REFFERENCES.pdf?v=1629728662\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":53256733917494,"sku":"672975315788","price":104.76,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/CALCIUM_FRONT_0680ed9c-b023-4b4f-bb16-19426a263d10.png?v=1762807484"},{"product_id":"b-complex","title":"B-Complex","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003eAid in energy metabolism.\u003c\/li\u003e\n\u003cli\u003eSupport optimal function of key structures, including the adrenal glands, musculoskeletal system, and digestive system.\u003c\/li\u003e\n\u003cli\u003eSupport cognition, mood, and overall well-being.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eB vitamins are a group of eight essential vitamins with several critical functions in the body. Among the B-complex’s many critical roles are energy (protein, carbohydrates, and fat) metabolism, supporting and maintaining the healthy function of the adrenal glands, skeletal muscle function, and digestion.\u003c\/p\u003e\n\u003cp\u003eWhile rates of metabolism and clearance differ between each B vitamin, all B vitamins are water-soluble and are thus not stored in fat. As a result, the body simply excretes excess B vitamins in the urine and requires replenishment (from food or supplements) in order to maintain the cell functions to which B vitamins contribute. Along with choline and inositol added, collectively this group of nutrients are essential for maintaining normal energy levels, cognition, mood, bodily function, and well-being.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eB Vitamins (Thiamine, Riboflavin, Niacin, B6 [Pyridoxine], Folic Acid, B12, Biotin, and Pantothenic acid)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eB vitamins are a group of eight essential vitamins with several critical functions in the body. Though both molecularly and physiologically distinct, they are also deeply interrelated in their effects, synthesis and metabolism. Among the B-complex’s many critical roles are energy (protein, carbohydrates, and fat) metabolism, supporting and maintaining the healthy function of the adrenal glands, skeletal muscle function, and digestion.\u003c\/p\u003e\n\u003cp\u003eWhile rates of metabolism and clearance differ between each B vitamin, all B vitamins are water-soluble and are thus not stored in fat. As a result, the body simply excretes excess B vitamins in the urine and requires replenishment (from food or supplements) in order to maintain the cell functions to which B vitamins contribute. Collectively this group of vitamins are essential for maintaining normal cognition, mood, bodily function, and well-being.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCholine\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCholine is an essential nutrient involved in numerous metabolic pathways, including DNA regulation and repair, protein function, and metabolism. Perhaps most importantly, the critical neurotransmitter acetylcholine is produced directly from free choline via cholinergic neurons. Acetylcholine is then responsible for a number of functions itself, most crucially as the compound which induces muscular contraction, and as the neuromodulator partially responsible for modulating risk\/reward, arousal, and enhancing memory.\u003c\/p\u003e\n\u003cp\u003eCholine’s essential role as a substrate for acetylcholine, and therefore brain development, is well documented in animal models. These studies demonstrate that levels of free maternal choline have a direct and fundamental impact on prenatal brain development, with the enhancements or deficits lasting into adulthood. Choline’s enhancing effect is particularly prominent in the hippocampus. In humans, the hippocampus is primarily involved in the consolidation of memory (taking short, episodic memory and translating it into long-term memory) and the learning of new information. Acetylcholine is a critical component in these processes, as mentioned above, and choline may therefore play a potential role in these processes as well by providing the substrate for acetylcholine synthesis\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInositol\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe nutrient inositol, also known as myo-inositol, was once called “vitamin B8”, however, it was later found to be produced by humans, and thus is not technically a vitamin. Inositol heightens the activity of serotonin in the brain, and thus has a vital role in mood and emotional balance. Inositol is also a type of sugar that influences the insulin response and several hormones associated with mood and cognition. It has antioxidant properties that fight the damaging effects of free radicals in the brain, circulatory system, and other body tissues.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-BCOMPLEX.jpg?v=1629733123\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/B-Complex_7.5x2.5-FIN-P65_17f66aba-94b0-40d1-b5c6-524ed0bc02e7.pdf?v=1644226214\"\u003eB Complex Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/B-Complex-REFFERENCES.pdf?v=1629727783\"\u003eDownload Refferences\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":53256734015798,"sku":"672975315795","price":95.24,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/B-Complex_RENDERING_020be836-b0ef-4286-a081-167ff735f3d4.png?v=1762807484"},{"product_id":"core-poise","title":"Poise","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eMagnesium and Iodine:\u003c\/strong\u003e Provides optimal thyroid hormone balance. Aids in menstrual symptom relief.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eChaste Tree Extract \u003c\/strong\u003e- Can provide menstrual symptom relief.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSetria® Glutathione\u003c\/strong\u003e - Antioxidant rich. Neutralizes free radicals.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBioPerine®\u003c\/strong\u003e - Increased bioavailability of key nutrients.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003ciframe src=\"https:\/\/www.youtube.com\/embed\/Xgrm_v6dDtc\" height=\"315\" width=\"560\"\u003e\u003c\/iframe\u003e\u003c\/p\u003e\n\u003cp\u003eNot every supplement is about “the gains.” While the sports nutrition and performance space, as the name implies, justifiably focuses on supplements that maximize athletic performance, too often the space neglects imperatives outside the gym. That is, the space ignores that we all exist outside the gym, at home and in the workplace, and have supplemental needs in these spaces too – to help us respond to and optimize our daily lives. This is especially true for women, who are too often marketed only “weight loss” supplements, ignoring that women have extensive physiological needs.\u003c\/p\u003e\n\u003cp\u003eAnd let’s face it: modern life only exacerbates these needs. Environmental stressors, work, inconsistent diet, and poor sleep habits all contribute to a lifestyle deleterious to the homeostasis of key bodily systems. Chief among them, the complex endocrine pathway that regulates the synthesis, distribution, and uptake of hormones. It is becoming increasingly hard to maintain the healthy and normal hormonal homeostasis that allows us to perform optimally in the gym and workplace. This is especially true for women.\u003c\/p\u003e\n\u003cp\u003eCore POISE is a unique and specifically formulated solution to this problem. Our tailored ingredient profile addresses the mechanisms associated with the body’s stress response. Key ingredients such as magnesium, DIM, Chaste berry, and pregnenolone, are all heavily involved in sex hormone biosynthesis and estrogen balance, and some have been demonstrated to mitigate some of the discomfort associated with PMS. Other ingredients, such as iodine, turmeric extract and Olea europaea help optimize your body’s response to stress, providing and supporting thyroid health. Stress impact on the thyroid can lead to a suppressed metabolism, which can lead to unwanted weight gain. So, while POISE will not make your life easier, it certainly makes responding to it easier.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMagnesium (as Magnesium Bisglycinate Chelate (TRAACS™):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIt is difficult to overstate the biological necessity of magnesium. Magnesium is a co-factor in over 300 enzymatic reactions that regulate essential physiological functions such as protein synthesis, glucose homeostasis, muscle and nerve function, and the maintenance and support of healthy blood pressure levels.\u003c\/p\u003e\n\u003cp\u003eIn addition to these benefits, magnesium (especially Magnesium Bisglycinate Chelate) has been studied for its benefits in reducing dysmenorrhea (menstrual cramps) through its ability to relax the smooth muscle of the uterus and reduce the prostaglandins that cause painful cramps. Magnesium levels also tend to fluctuate during a menstrual cycle. During the second half of a cycle when estrogen and progesterone are higher, magnesium levels tend to drop even more. Supplementation with a high-quality magnesium can assist in maintaining an optimal level.\u003c\/p\u003e\n\u003cp\u003eMagnesium’s influence on the thyroid is also of importance. Magnesium is responsible not only for making the inactive T4 (thyroxine) in the thyroid gland but also for converting T4 into the active form of T3 (triiodothyronine). This is important because the metabolism of your body’s cells is enhanced by T3 specifically. These two hormones have a large influence on metabolic rate, heart and digestive function, muscle control, brain development and bone maintenance. Studies have shown that severely low serum magnesium can be associated with an increased risk of anti-thyroglobulin antibodies, which can be a sign of thyroid gland damage caused by the immune system. It has also shown an increased risk of Hashimoto thyroiditis and hypothyroidism, two common autoimmune disorders.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIodine:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIodine is a trace element naturally present in certain foods, including kelp. Iodine is a critical component for fetal development, especially during early pregnancy, as maternal T4 (thyroxine) is the sole source of fetal thyroid hormone. After birth, especially if breast-feeding, iodine remains an important constituent of a balanced-diet to maintain adequate T3 (triiodothyronine) and T4 (thyroxine) levels in the mother and for proper cognitive development in the child.\u003c\/p\u003e\n\u003cp\u003eAs implied, however, the most important of iodine’s functions is assisting the body’s production and maintenance of both thyroid hormones and TSH (thyroid stimulating hormone, released by the pituitary). The thyroid hormones, in turn, regulate several critical biochemical reactions, including protein synthesis, and, along with norepinephrine\/epinephrine, largely determine the body’s metabolic rate.\u003c\/p\u003e\n\u003cp\u003eIn addition to these benefits for the thyroid, iodine can also be a critical element for women’s health. About 70% of the body’s iodine is concentrated in the tissues of the brain, immune system, ovaries, uterus, breasts, and prostate gland (in men). Being this close to the female reproductive system, iodine also has a large effect on ovulation and estrogen. Iodine is believed to reduce ovulation pain, prevent ovarian cysts, and boost progesterone levels when there is too much estrogen present, which can cause heavy menstruation, breast pain, fibroids, and premenstrual irritability. Iodine can also help reduce estrogen related side effects in two ways: by promoting healthy detoxification of estrogen and by making cells less sensitive to estrogen.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eL-Tyrosine:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eTyrosine is amongst a class of amino acids known as ‘non-essential’ amino acids, so called because the body can produce them endogenously, and it is therefore not essential through dietary means. That being said, tyrosine is also what is known as a conditionally-essential amino acid; conditionally-essential because, along with glucose and ammonia, the synthesis of tyrosine additionally requires adequate levels of phenylalanine. Once synthesized, tyrosine is one of the most critical amino acids, given its prominent role as a substrate in the synthesis of the catecholamines dopamine, norepinephrine, and epinephrine, in addition to both T3 (triiodothyronine) and T4 (thyroxine) thyroid hormones.\u003c\/p\u003e\n\u003cp\u003eThyroid hormones are in fact derivatives of tyrosine that are bound covalently to iodine, meaning that tyrosine (as well as iodine) needs to be present in order for thyroid hormones to be produced. This supplementation can boost thyroid hormones levels in those who may have suppressed thyroid hormones levels. (It is important to note, however, that individuals who are already being prescribed thyroid medications or have an overactive thyroid should be cautious when supplementing with tyrosine and should seek the guidance of a healthcare professional prior to supplementing).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTurmeric Extract (Curcuma longa) (root) (95% curcuminoids):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCurcumin, the primary curcuminoid found in turmeric (a root known for its spice), has been the basis of many clinical studies for its therapeutic properties and ability to modulate multiple cells signaling pathways in certain inflammatory diseases known to humans.\u003c\/p\u003e\n\u003cp\u003eNumerous studies seem to suggest that curcumin powerfully inhibits the enzymes that synthesize inflammatory compounds such as prostaglandins and leukotrienes. In particular, basic research and molecular studies have now firmly established curcumin’s ability to dose-dependently and potently inhibit a transcription factor known as NF–kB – a molecule involved in the proliferation of pro-inflammatory cytokines, soft tissue destruction, and autoimmune responses. In relation to autoimmune conditions, Hashimoto’s thyroiditis is one in particular that is considered the leading cause of hypothyroidism. The overabundance of chronic inflammation found in the thyroid during these conditions can lead to less production of thyroid hormone all together, thus leading to a generalized slowing of a person’s metabolism.\u003c\/p\u003e\n\u003cp\u003eTurmeric can also have a positive impact on PMS related symptoms. This is seen primarily through the increased neurotransmitter release and inflammatory response associated with pre-menstrual occurrences. Many of the mood and behavior changes associated with PMS can be traced to neurotransmitter changes such as decreased norepinephrine, dopamine, and serotonin. These changes can be subject to the decline in estrogen and progesterone during this period. Turmeric has been shown in studies to increase these neurotransmitters, thus impacting these symptoms in a positive way. The increased inflammatory response due to the PMS period as well can be mitigated in the presence of turmeric due to its high anti-inflammatory benefits.\u003c\/p\u003e\n\u003cp\u003eStudies have shown that low quality curcumin has low bioavailability and benefit, which is why we have used a high standard curcumin with 95% curcuminoids and have also included the trademarked Bioperine® in this formula. These two ingredients have a largely cohesive impact that can drastically improve the health benefit. Studies have shown that Bioperine® significantly improved curcumin uptake by upwards of 2000% at doses that proved to be clinically beneficial.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOlive Extract (Olea europaea) (leaf) (20% Oleuropein):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eUsing products derived from the olive tree for the basis of benefitting human health dates back several centuries. There has been a good body of research done lately on the benefits of olives and its derivatives. The polyphenols found in olives (and unrefined virgin olive oil) contain highly potent antioxidant and free radical fighting properties, making them highly sought out for their anti-inflammatory and immune boosting benefits. As we have discussed in subsequent ingredients and their benefits, these anti-inflammatory and immune boosting benefits include the positive impacts made towards thyroid health and PMS. Oleuropein is the most potent polyphenol found in olives (our source of olives contains 20%) and exhibits a very high antioxidant effect on the body through different mechanisms, resulting in an enhanced antioxidant response. This potential is mainly related to its ability to improve radical stability through the formation of intramolecular hydrogen bonds. Oleuropein may also be able to counteract oxidative stress and has shown in vitro to have a protective effect on lipid oxidation. As mentioned above, olive-derived phenolic compounds, including oleuropein, can have a beneficial anti-inflammatory effect. These compounds can decrease concentrations of pro-inflammatory agents that stimulate more inflammation in several different pathologies. It has been studied that oleuropein is able to elicit protective effects on modulating parameters of inflammation and other oxidative stressors.\u003c\/p\u003e\n\u003cp\u003eOleuropein has also been seen is studies to have positive impacts on thyroid conditions, in particular hypothyroidism (underactive thyroid), where the thyroid underproduces thyroxine and and overproduces Thyroid Stimulating Hormone (TSH). This high level of TSH can be expressed from the pituitary gland secreting excess amounts of TSH to stimulate the thyroid gland to produce more thyroid hormone in an attempt to balance secretions. Olive leaf supplementation has been shown to positively impact the thyroid this by promoting a lowering of TSH levels and increasing T3 (triiodothyronine) levels in an attempt to normalize thyroid function.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eChaste Tree Extract (Vitex agnus-castus) (fruit) (1.5% Agnusides)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eChaste Tree Berry, also known as Vitex agnus castus (VAC), is a shrub that is native to both Mediterranean Europe and Central Asia. Clinical reviews have supported the use of VAC as a remedy for many female conditions, including menstrual disorders (amenorrhea, dysmenorrhea), premenstrual syndrome (PMS), corpus luteum insufficiency, hyperprolactinemia, infertility, acne, menopause, and disrupted lactation. Chaste Berry exhibits a mechanism of action that increases dopamine activity in the brain, which results in a reduction of prolactin release in the body. When there is an increase in prolactin it can cause disturbances in a women’s menstrual cycle as well as deficiency in their levels of estrogen and progesterone. A prospective, multicenter trial in the efficacy of VAC on PMS was investigated in 50 patients. The Moos’ menstrual distress questionnaire (MMDQ) was the primary parameter and self-assessment was the second parameter. The inclusion of VAC showed that PMS-related symptoms were reduced but then gradually returned after cessation of the trial period. Studies such as this one show that using VAC as a remedy for the symptoms associated with PMS can show clear improvements but should mainly be used for symptomatic relief rather than relief for the duration of the syndrome.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSetria® L-Glutathione:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePMS is often a high stress event for an individual. The overabundance of estrogen compared to progesterone can increase overall stress. When cortisol is not controlled, it can further lower progesterone, further dividing the needed balance between these two complimentary hormones. Glutathione is an amino acid containing molecule of L-glutamic acid, L-cysteine, and Glycine. It is vital to many different properties and is best known for being a powerful antioxidant. The ‘glutathione system’ comprises the enzymes that synthesize glutathione within a cell as dedicated enzymes that use glutathione for its antioxidant effects. Glutathione supplementation is thought to support this pool of glutathione present in cells and thus maintain the efficacy of the entire system. Free radicals can be a byproduct of many different things such as exercising, eating, and breathing to name a few. When these molecules overcome the body at the cellular level, this constant barrage can have negative impacts on health and overall wellness. This barrage can also include the stresses that one’s body might endure during pre-menstruation. Setria® L-Glutathione provides a potent supply of antioxidants that bind these free radicals, which can help keep them from causing lasting damage. Glutathione not only has the ability to neutralize free radicals, but it also can reactivate other antioxidants, such as Vitamin C and Vitamin E. Once these vitamins and their antioxidants do their job of neutralizing free radicals, they become unstable radicals themselves. Glutathione can help recycle these unstable molecules back to their antioxidant rich properties.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e3,3'-Diindolylmethane (DIM):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWhat we typically refer to as “Estrogen,” is in fact a group of three biologically distinct hormones – estradiol (E2), estrone (E1), and estriol (E3), each possessing different activities in different cell, tissue, and receptor types. When experts refer to either the benefits or downfalls of “estrogen,\" they really mean to (but probably cannot) identify a \u003cem\u003especific\u003c\/em\u003e estrogen.\u003c\/p\u003e\n\u003cp\u003eThese \u003cem\u003especific\u003c\/em\u003e estrogens, in turn, metabolize into even more specific estrogen sub-compounds, such as the 2-hydroxyestrogens (2-OHE’s), 2-methoxyestrogens, 16a-hydroxyestrone (16-OHE1), and 4-hydroxyestrogens (4-OHE’s). As their parent estrogens, these estrogen metabolites exert different effects depending upon the tissue and cell one is examining. In fact, two estrogen metabolites in particular, 16-OHE1 and 2-OHE, have such contrasting cellular activities that 2-OHE is an estrogen antagonist. Yes, that is correct: there is an anti-estrogen, estrogen.\u003c\/p\u003e\n\u003cp\u003eIn recent years, so-called “phytonutrients” have become the focus of clinical research, as these natural compounds have shown the ability to increase the ratio of good, estrogen decreasing estrogens (such as 2-OHE), to bad, estrogen increasing estrogens (such as 16-OHE1). One of these phytonutrients, a dietary indole known as indole-3-carbinol (I3C), is the bioactive phytochemical and a presumed modulator of reduced cancer risk in areas with high cruciferous vegetable consumption. Unfortunately, despite its potent antiestrogenic activity, I3C is highly molecularly unstable, and therefore unsuitable for use as a therapeutic agent or dietary supplement.\u003c\/p\u003e\n\u003cp\u003eLuckily, however, I3C readily metabolizes into the secondary indole 3,3’ diindolylmethane, or DIM for short. When used in a supplemental fashion in clinical trials, DIM appears to possess all the positive effects of its parent compound with respect to antiestrogenic action – promoting the metabolism of beneficial estrogens that themselves reduce estrogenic activity.\u003c\/p\u003e\n\u003cp\u003eAside from its healthy-estrogen promoting abilities, DIM also exerts its own direct physiological effects, including:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003ePromoting pathways of internal estrogen metabolism that favor the production of anti-estrogen estrogens.\u003c\/li\u003e\n\u003cli\u003eAdjusting the activity of certain cytochrome enzymes, reducing the activity at the estrogen receptor site.\u003c\/li\u003e\n\u003cli\u003eLimit the cell division and growth of certain estrogens.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eDespite the bodybuilding community’s single-minded crusade to eliminate estrogen wherever it lie in wait, compounds such as DIM show us that estrogen is a very diverse set of compounds – and that we should actively pursue increasing certain estrogens that have beneficial, and ironically, anti-estrogenic effects\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePregnenolone: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePregnenolone, or pregn-5-en-3β-ol-20-one, is known as the grandmother hormone due to its precursor role in the endogenous biosynthesis of most steroid hormones as well as others, including progesterone and estrogen. Pregnenolone also has a high relationship in the balancing of beta-estradiol and progesterone, which can have a positive impact on the distressing of symptoms associated with PMS, including menopausal depression. When pregnenolone levels are low, whether it be due to high amounts of oxidative stress, increased cortisol, etc. it can have a negative impact on other bodily functions that are governed by hormones. When women in particular have low progesterone during their monthly cycle, it can lead to heavy menstruation and increased levels of estrogen, which can decrease sex drive and increase weight gain. Pregnenolone needs to be present in order for the balance of progesterone and estrogen to occur. This balance of hormones can thus lead to more balance during the menstruation period and lower the severity of PMS symptoms.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBioperine® (95% Black Pepper Extract):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBioPerine® is a patented standardized extract from the fruit of Piper nigrum (black pepper). It’s studied benefits have shown improvements in bioavailability of nutrients it is surrounded by. In this specific product for Core POISE, it is included because it dramatically increases the bioavailability of curcuminoids (see above). Without Bioperine, the serum concentration and absorption rates of the active agents in curcumin would be significantly reduced.\u003c\/p\u003e\n\u003cp\u003eBioPerine® primarily works through mechanisms and channels that can inhibit intestinal motility and dilate blood vessels of the intestines (where absorption of nutrients occurs). This physiological action may cause increased absorption and digestion of nutrients.\u003c\/p\u003e\n\u003cp\u003eSeveral studies looking at the impact of BioPerine® on nutrient absorption have been done. One study looking at the efficacy of BioPerine® on serum concentrations of curcumin showed bioavailability was improved by more than 500%. Therapeutic effectiveness of curcumin has often been exhibited as low. Another study conducted over the course of 6 weeks on BioPerine® influence on serum selenium levels in humans showed an increase by 145% over the presupplementation value.\u003c\/p\u003e\n\u003cp\u003eWith promising research being done on the effects of BioPerine® in the context of nutrient absorption and bioavailability, it is only fitting that we include it in Core POISE.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg class=\"img-responsive\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-POISE-2020.jpg?v=1607511548\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_POISE-PR_7.125x2.625_FIN-OL.pdf?v=1639556575\"\u003eCore POISE Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Poise_Refferences.pdf?v=1607340646\" target=\"_blank\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":53256734900534,"sku":"672975009328","price":180.95,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/POISEFRONT_dc557258-5d50-43f9-aa81-aeaecd79e822.png?v=1762807488"},{"product_id":"core-sear","title":"Sear","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eSinetrol®\u003c\/strong\u003e - Blend of polyphenols aiding in weight management\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMitoBurn™\u003c\/strong\u003e - Initiates the \"browning\" of adipose tissue\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eParadoxine®\u003c\/strong\u003e - Non-stimulant thermogenesis\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003ciframe src=\"https:\/\/www.youtube.com\/embed\/ndKqOPtB8qA\" height=\"315\" width=\"560\"\u003e\u003c\/iframe\u003e\u003c\/p\u003e\n\u003cp\u003eWhy do we call it “burning fat”? It is a strange turn of phrase, as the body does not “burn” the adipose tissue (the technical name for “fat”). Of course, heat is involved in the base process of fat metabolism, hydrolysis, but the average person of course does not have this in mind. What the common phrasing captures is that the adipose tissue is now being used for fuel – burned up, as gasoline is burned up in a combustion engine as fuel for the vehicle. In this sense, the phrase “burning fat” captures something essential about the mechanisms of adipose metabolism. One mechanism of increasing this process overall is increasing the conversion of WAT (white adipose tissue) to BAT (brown adipose tissue) – known as the “browning” of fat.\u003c\/p\u003e\n\u003cp\u003eIt is precisely this mechanism that Core SEAR affects. There are many pathways to enhance lipolysis, the process by which stored triglycerides – the “stuff” of fat tissue – are broken down to release their potential energy into actual energy. One of the most effective is modulating the enzymes that interconvert WAT (white adipose tissue, which stores energy) to BAT (brown adipose tissue, which releases energy) and the chemical and enzymatic cascades that induce lipolysis. SEAR addresses both. Sinetrol XPur®, a blend of citrus fruit extracts, and MitoBurn™, a metabolite of L-valine, have been demonstrated to increase white-to-brown adipose tissue conversion and therefore the resultant energy expenditure increase. Meanwhile, Coleus forskholli and Paradoxine® have been shown to heavily influence cellular communication and enzymatic pathways involved in lipolysis, specifically the cAMP and AMPk pathways.\u003c\/p\u003e\n\u003cp\u003eTogether, this simple but incredibly powerful formula earns its name: searing white into brown adipose tissue and increasing your body’s energy expenditure due to fat metabolism.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSinetrol® XPur [blend of Grapefruit (\u003cem\u003eCitrus paradise L.\u003c\/em\u003e) (fruit), Guarana (\u003cem\u003ePaullinia cupara Kunth\u003c\/em\u003e) (seed), Sweet Orange and Blood Orange (\u003cem\u003eCitrus sinesis L. Osbeck\u003c\/em\u003e) (fruit Extracts)]:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMetabolism involves the chemical reactions that break down the foods we eat into separate compounds. Sugars, fats, and amino acids provide our body with energy to function on a daily basis. These compounds can help our body carry out many functions but when overconsumed they get stored as energy in specific adipose (fat) cells. These cells make up our fatty tissue and can further be classified as white adipose tissue (WAT) and brown adipose tissue (BAT). The color of brown fat is due to a larger number of mitochondria being present in those tissues. Mitochondria are the energy producing structures of the cells. Most of our body’s fat is WAT, which stores energy, and when to much WAT builds up the outcome is obesity. This can also be characterized as an enlargement in adipocyte size that results from increased triglyceride storage. Brown adipose tissue, or BAT, on the other hand breaks down blood sugar (glucose) and fat molecules into usable forms of energy, mainly to create heat and maintain body temperature (homeostasis). The ratio between these two adipose tissue types determines the level of energy expenditure, which is unbalanced in those who have more body fat. Research has been centered around finding optimal ways to tap into BAT’s ability to improve obesity, and other metabolic issues.\u003c\/p\u003e\n\u003cp\u003eSinetrol® is a unique blend of citrus polyphenols that are specifically meant to target body fat mass and improve long term body composition. These citrus polyphenols have been shown to enhance the physiological energetic pathways that influence lipolysis, destoring fat that has been accumulated within white adipose cells. This process occurs at the adipocyte level, helping to reach a balance between energy storage and usage, through a process of browning of adipocytes. Sinetrol® enhances the bodies physiological lipolysis process through phosphodiesterase (PDE) inhibition. This inhibition causes the rate of cyclic adenosine monophosphate (cAMP) to be maintained at sufficient levels, which is needed to enhance the baseline lipolysis yield. This process does two things. First, it can increase lipase activity, which is essential for breaking off fatty acids from triglycerides. Second, it can stimulate an increase in the number of mitochondria in your adipose tissue (mitochondrial myogenesis), thus giving your adipose tissue a brown color in appearance. In addition to this browning process, a protein called UPC-1 (uncoupling protein) is also increased. Studies have shown that it is through these primary mechanisms of action that Sinetrol® exhibits the benefit of enhancing lipolytic rate and browning of adipocytes, leading to increased thermogenesis and utilization of fatty acids and sugars as usable forms of energy.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMitoBurn™ (L- β-Aminoisobutyric Acid):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIn recent studies, MitoBurn™ (L-BAIBA), a metabolite of L-valine, has the ability to stimulate certain “exercise factors” that are released from skeletal muscle in response to muscular stress, in particular muscle contraction. L-BAIBA, a powerful myokine, plays a role in the benefits of regular exercise and begins a positive sequence of events, some of which include increased fatty acid oxidation, improved glucose uptake, and reduced fat mass. Although L-BAIBA primarily works to initiate the “browning” of adipose tissue, it also has been shown to decrease the “beiging” of adipose tissue. This beiging process is when the body reverses the preferred adipose tissue color of brown (high energy usage) back to white (high energy storage). Although most studies have been completed in rats, some results that have been obtained in cell culture models and human cohorts and shown a novel function to support L-BAIBA’s involvement in regulation of carbohydrate and lipid metabolism. These studies also support that L-BAIBA primarily exhibits its benefits in conjunction with physical activity. This is shown from skeletal muscle myokines (peptides) that play an important role is the processes listed above. These myokines are produced, expressed, and released by muscle fibers when under forceable contractions and exert both local and pleiotropic effects. Myokines also help to configure the immune-metabolic factor interactions and health promoting effects of physical exercise that stimulate the communication between skeletal muscle and adipose tissue. Adipose tissue itself will release proinflammatory cytokines in response to inactivity and can be a leading reason for the development of metabolic diseases.\u003c\/p\u003e\n\u003cp\u003eThis supported research of MitoBurn™ (L-BAIBA) and its benefits show that through its myokine activity and communication through physical activity as well as its ability to aid in the browning of adipose tissue, lead it to be a proposed beneficial intervention for the purposes of body composition improvements.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eColeus forskohlii\u003c\/em\u003e Extract (root) (20% forskolin):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eColeus forskohlii\u003c\/em\u003e is a small perennial endemic to various tropical regions in the world, including South America, sub-Saharan Africa, and India. While the West has recently taken interest in the plant due to the pharmacological properties of its primary bioactive, forskolin, \u003cem\u003eColeus forskholii\u003c\/em\u003e preparations and tinctures have been used in both South American and African traditional folk medicinal systems, as well as extensively within Ayurveda. Due to the ever-increasing interest in the plant’s verifiable pharmacological and physiological effects, however,\u003cem\u003e Coleus forksholii\u003c\/em\u003e and its extracted constituents have been the subject of numerous animal and human clinical trials in the past decade. These trials have demonstrated the plant to have various effects and applications, including as a lipolytic and anti-lipogenic, and as a powerful antioxidant.\u003c\/p\u003e\n\u003cp\u003eA recent double-blind, randomized, and placebo-controlled human clinical trial featuring obese men found that the daily implementation of \u003cem\u003eColeus forskholii\u003c\/em\u003e, for twelve weeks, led to significantly better weight loss outcomes as compared to controls. Overweight men in the forskolin group experienced not only improved body composition (as measured by both body fat percentage and total fat mass), but also statistically significant increases in lean body mass. \u003cem\u003eColeus forskholii\u003c\/em\u003e – and more specifically, forskolin – achieves this effect by rapidly, potently, and dose-dependently increasing an important metabolic enzyme known as adenylate cyclase. Adenylate cyclase is an enzyme responsible for catalyzing the formation of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). This increase in cAMP formation eventually leads to the activation of an enzyme, protein kinase A, which in turn will phosphorylate and hence activate the enzyme, Hormone Sensitive Lipase (HSL) – the rate-limiting enzyme necessary for stored triglycerides within adipocytes to be released as free fatty acids and utilized for energy. In more basic terms, this means that forskolin quite literally frees up more fatty acids to be used as fuel for exercise – more or less the perfect scenario in a product such as Core SEAR!\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eParadoxine® Grains of Paradise (std. to 12.5% 6-Paradol):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eAframomum melegueta\u003c\/em\u003e, more commonly known as Grains of Paradise, or the alligator pepper, is a plant in the Ginger (\u003cem\u003eZingiberaceae\u003c\/em\u003e) family. While complete compositional analysis has not been performed on Grains of Paradise, preliminary assays demonstrate is structural and chemical similarity to ginger – principally in that both ginger and grains of paradise contains a range of pungent bioactives, one of which is 6-paradol. 6-paradol acts as a lock and key mechanism to work along side the mechanisms of action of the other ingredients found in Core Sear.\u003c\/p\u003e\n\u003cp\u003eParadoxine® specifically is an ethanol extract of Grains of Paradise. Studies have shown that this extract can increase energy expenditure through its browning of fat tissue (similar to Sinetrol® and Mitoburn™).\u003c\/p\u003e\n\u003cp\u003eAlso, along with 6-shogaol, 6-paradol appears to be the most bioactive of the approximately 14 pungent compounds identified in ginger. Both compounds appear to potently and dose-dependently mediate the PI3K (phosphoinositide 3-kinase)\/PKB (protein kinase B), leading specifically to an increase in AMPk phosphorylation. Known as the ‘master regulatory switch,’ AMPk is responsible for balancing endergonic (energy absorbing) and exogenic (energy liberating) processes in the body’s response to energy demands. AMPk is therefore heavily involved in adipocyte (fat cell) differentiation, proliferation, and hypertrophy, via regulating both enzymatic action (11B-HSD1, HSL, SREBP-1) and downstream lipogenic genes such as PPARy2.\u003c\/p\u003e\n\u003cp\u003eIn the case of gingerols such as 6-paradol, increased phosphorylation of AMPk in adipocytes appears to have a mitigating effect on hypertrophy by reducing lipid synthesis. 6-paradol appears to increase AMPk, which in turn decreases the mRNA expression of the downstream PPARy2 (peroxisome proliferate activated receptor gamma 2), a nuclear receptor gene principally responsible for lipid accumulation. In other words, the gingerols control a compound (AMPk) which, in turn, controls fat mass metabolism.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/812a9102306e35017d3717fdad9aab08.png?v=1758304117\" class=\"img-responsive\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/SEAR_References.pdf?v=1609846574\" target=\"_blank\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":53256735064374,"sku":"672975315597","price":209.52,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/SEAR_eb5388f5-a973-4a6b-b462-c1619ad4006f.png?v=1762807489"},{"product_id":"zinc","title":"Zinc","description":"\u003ch2 class=\"slogan\"\u003e\u003cb\u003e\u003cspan\u003eBOOST\/PREVENT\/AID\u003c\/span\u003e\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eZinc has been shown to:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003esupport the function of cells related to immune response\u003c\/li\u003e\n\u003cli\u003eaid in metabolic function\u003c\/li\u003e\n\u003cli\u003esupports normal testosterone production\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eIf there ever was a super hero amongst mineral, zinc would be it. This mineral is crucial and is essential for more than 200 different enzymatic reactions in the human body. In other words, it is essential to keep you living and performing at a high-level day in and day out. Your body gets put through the ringer day in and day out and you cant do it alone, consider zinc to be the director of the show supporting you internally.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eFull Science:\u003c\/b\u003e Zinc is a beneficial mineral that has been often researched for its significant immune-supportive benefits. Zinc has a role in every single cell of our bodies and is an important co-factor in over 200 enzymatic reactions that induce functions such as:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eWhite blood cell production\u003c\/li\u003e\n\u003cli\u003eTestosterone production\u003c\/li\u003e\n\u003cli\u003eEye health\u003c\/li\u003e\n\u003cli\u003eSkin health\u003c\/li\u003e\n\u003cli\u003eNormal growth and development\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eZinc in the \u003ci\u003echelated\u003c\/i\u003e form (\u003ci\u003ebisglycinate\u003c\/i\u003e) has been studied and shown to offer a form that is superior in its absorptive properties and is very well tolerated by the human body. This form is absorbed intact and thus does not compete with other minerals for absorption in the digestive tract.\u003c\/p\u003e\n\u003cp\u003eOne comparative study consisting of 30 female participants given a random form of zinc or placebo showed that the participants given zinc \u003ci\u003ebisglycinate\u003c\/i\u003e had significant increases in serum blood levels of zinc compared to other forms.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/commodities-supp-facts-2020-ZINC_743d65bb-d91c-4d65-a2ca-868fa3980109.jpg?v=1603352125\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_Zinc_2020_6.25x2.25_FIN-OL.pdf?v=1644227551\"\u003eZinc Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eReferences\u003c\/b\u003e:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eGandia P, Bour D, Maurette J-M, et al. A bioavailability study comparing two oral formulations of zinc (Zn bis-glycinate vs. Zn gluconate) after a single administration to twelve healthy female volunteers. \u003ci\u003eInt J Vitamin Nutr Res\u003c\/i\u003e 2007;77(4):243-248.\u003c\/li\u003e\n\u003cli\u003eDiSilvestro R, Koch E, Rakes L. Moderately high dose zinc gluconate or zinc bisglycinate: effects on plasma zinc and erythrocyte superoxide dismutase in young adult women. \u003ci\u003eBiol Trace Elem Res\u003c\/i\u003e 2015;168(1):11-14.\u003c\/li\u003e\n\u003cli\u003eDiSilvestro R, Swan M. Comparison of four commercially available zinc supplements for performance in a zinc tolerance test. \u003ci\u003eFASEB J\u003c\/i\u003e 2008;22:693.3.\u003c\/li\u003e\n\u003cli\u003eDiSilvestro R, Hart S, Marshall T, et al. Enhanced aerobic exercise performance in women by a combination of three mineral chelates plus two conditionally essential nutrients. \u003ci\u003eJ Int Soc Sports Nutr\u003c\/i\u003e 2017;14:42.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":53256735719734,"sku":"672975315467","price":76.19,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/ZINC_FRONT_323f442c-0eea-4032-be78-eaeecf8c4f1b.png?v=1762807494"},{"product_id":"vitamin-c","title":"Vitamin C","description":"\u003cp\u003eVitamin C, also known as ascorbic acid, is an essential vitamin for the human body possessing high antioxidant properties. Some of its primary benefits include:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eImmunity and wound healing\u003c\/li\u003e\n\u003cli\u003eGrowth and development of all body tissues\u003c\/li\u003e\n\u003cli\u003eCollagen formation, including the maintenance of cartilage, bones, and teeth\u003c\/li\u003e\n\u003cli\u003eAbsorption of Iron\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eVitamin C is probably something most have heard of being an importance since an early age. Just as it benefits supporting normal growth and development during early life stages, it continues to benefit life expectancy and preservation as we age.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eVitamin C is perhaps historically best-known for the treatment and prevention of scurvy, though it has many other roles in the body. For example, vitamin C catalyzes or is a cofactor in eight enzymatic reactions involved in the synthesis of collagen, the nutrient carnitine, and several neurotransmitters necessary for the proper function of the brain.\u003c\/p\u003e\n\u003cp\u003eIn the contemporary context, vitamin C is best known as a potent antioxidant. In addition to its intrinsic activity as an antioxidant, vitamin C has been shown in in vitro trials to regenerate alpha-tocopherol (vitamin E). As an antioxidant, vitamin C combats the detrimental effects of a group of compounds called radical oxygen species that, when produced, degrade the lipid membrane of the cell and may cause internal damage. By “scavenging” these free radicals, vitamin C and other antioxidants form a defense against excess cellular damage.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/commodities-supp-facts-2020-VITAMIN_C_772e2a5a-35df-424b-8049-cf4c7b223047.jpg?v=1603352125\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_Vitamin_C_2020_8.5x3.25_FIN-OL_1.pdf?v=1726584664\"\u003eVitamin C Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eReferences:\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e1.\u003c\/b\u003e “Ascorbic Acid”. \u003ci\u003eThe American Society of Health-System Pharmacists\u003c\/i\u003e. Archived from the original on December 30, 2016. Retrieved December 8, 2016.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e2.\u003c\/b\u003e “Fact Sheet for Health Professionals - Vitamin C”. \u003ci\u003eOffice of Dietary Supplements, US National Institutes of Health\u003c\/i\u003e. February 11, 2016. Archived from the original on July 30, 2017.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e3.\u003c\/b\u003e \u003ci\u003eWHO Model Formulary 2008\u003c\/i\u003e (PDF). World Health Organization. 2009. p. 496. ISBN 9789241547659. Archived (PDF) from the original on December 13, 2016. Retrieved December 8, 2016.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e4.\u003c\/b\u003e Hemilä H, Chalker E (January 2013). “Vitamin C for preventing and treating the common cold”. \u003ci\u003eThe Cochrane Database of Systematic Reviews\u003c\/i\u003e (1): CD000980. doi:10.1002\/14651858.CD000980.pub4. PMID 23440782.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e5.\u003c\/b\u003e Ye Y, Li J, Yuan Z (2013). “Effect of antioxidant vitamin supplementation on cardiovascular outcomes: a meta-analysis of randomized controlled trials”. \u003ci\u003ePLOS One\u003c\/i\u003e. 8 (2): e56803. Bibcode:2013PLoSO...856803Y. doi:10.1371\/journal.pone.0056803. PMC 3577664 . PMID 23437244.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e6.\u003c\/b\u003e Duerbeck NB, Dowling DD, Duerbeck JM (March 2016). “Vitamin C: Promises Not Kept”. \u003ci\u003eObstetrical \u0026amp; Gynecological Survey\u003c\/i\u003e. 71 (3): 187–93. doi:10.1097\/OGX.0000000000000289. PMID 26987583.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e7.\u003c\/b\u003e “Ascorbic acid Use During Pregnancy | Drugs. com”. \u003ci\u003eDrugs.com\u003c\/i\u003e. Archived from the original on December 31, 2016. Retrieved December 30, 2016.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e8.\u003c\/b\u003e Institute of Medicine (2000). “Vitamin C”. \u003ci\u003eDietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids\u003c\/i\u003e. Washington, D.C.: The National Academies Press. pp. 95–185. ISBN 0-309-06935-1. Archived from the original on September 2, 2017. Retrieved September 1, 2017.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e9.\u003c\/b\u003e “Vitamin C”. \u003ci\u003eMicronutrient Information Center, Linus Pauling Institute, Oregon State University, Corvallis, OR\u003c\/i\u003e. January 14, 2014. Retrieved March 22, 2017.\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":53256735850806,"sku":"672975315443","price":76.19,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/VITC_FRONT_7f50ecc9-48a6-4ffa-ba52-2c2278a1fcfe.png?v=1762807496"},{"product_id":"core-flex","title":"Flex","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eCissus\u003c\/strong\u003e - Improved joint function and strength\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBoswellia\u003c\/strong\u003e - Promotes healthy tendons and strengthens cartilage\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eChondroitin\u003c\/strong\u003e - Contains antioxidants to help boost recovery\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003ciframe height=\"315\" width=\"560\" src=\"https:\/\/www.youtube.com\/embed\/9KN8QfvzZqI\"\u003e\u003c\/iframe\u003e\u003c\/p\u003e\n\u003cp\u003eDon’t leave your recovery to chance.\u003c\/p\u003e\n\u003cp\u003eCore FLEX is an ultra-potent combination of 11 clinical ingredients, crafted to ensure the maintenance of strong and healthy tendons and ligaments. Best of all, its all-in-one blend combines the efficacy of single ingredient products, with the synergy of an entire joint product lineup.\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e8 tablets per serving.\u003c\/li\u003e\n\u003cli\u003e30 servings per container.\u003c\/li\u003e\n\u003cli\u003eSoft tissue support.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eWe’ve all been there. You have a bit of cashed saved up, and a hard choice to make: do you buy the new, shiny toy, or fix that sort of irritating sound your engine is making? I mean, sure, maybe the engine breaks down, but that’s only a possibility – you will most certainly enjoy that new toy! Am I right?\u003c\/p\u003e\n\u003cp\u003eWrong. Just like a vehicle, our bodies are exposed to the constant wear and tear of demanding daily use, a fact especially true of athletes. As we put more and more weight on the bar, run faster and further, and push our bodies to the limit, our joints, tendons, and ligaments require regular maintenance to keep them in optimal health. We need to fix that sort of irritating sound our engine is making, in other words.\u003c\/p\u003e\n\u003cp\u003eCore FLEX provides a superior way to do so. Core FLEX is an ultra-potent combination of 11 ingredients, verified by clinical research and included in clinical serving sizes, crafted to ensure the maintenance of strong and healthy tendons and ligaments. Best of all, Core FLEX’s all-in-one blend combines the efficacy of single ingredient products, with the synergy of an entire joint product lineup.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhysiological Properties and Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eChondroitin and Glucosamine:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eChondroitin and Glucosamine are substances found naturally in the body, and in particular, in and around the cartilage and other connective tissues.Glucosamine falls within a class of compounds known as amino sugar, and is a precursor to a molecule called glycosaminoglycan. The human body produces and distributes both of these compounds as critical components in the production of cartilage and other connective tissue . It also aids in lubricating and providing thickness to the cartilage around damaged joints. Chondroitin sulfate is a type of glycosaminoglycan and complex carbohydrate rich in sulfur, and is a relative of glucosamine. Chondroitin is one of the major constituents of cartilage, not only providing structure and stability, but also water for the purpose of lubrication.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethylsulfonylmethane (MSM):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMSM is a naturally occurring, organosulfur molecule that can be synthesized both naturally and synthetically from DSMO. While the majority of MSM present in the human body is ingested – either deliberately or accidentally – the compound does have a natural presence in certain tissues and fluids in the body, including cerebrospinal fluid. MSM appears to assist healthy biochemical communication between cells that may assist joint flexibility and mobility. While still emerging, certain data on MSM appears to show a promising role for the compound in the maintenance of proper joint function. Several studies demonstrate joint function increases on the WOMAC scale ranging from 20-35%, while animal data suggests equally significant results. Though not every trial on MSM reveals such significant results, a meta-analysis conducted in 2011 found that the overwhelming majority of clinical MSM trials featured function improvements over placebo.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCissus quadrangularis:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCissus quadrangularis (CQ) is a plant with a long history of use in traditional and folk medicinal systems, including thousands of years of documented use in the Siddha and Ayurvedic traditions. While the specific use of Cissus in these systems varied, the most common traditional preparations related to analgesia, general tonics, and bone fracture healing. More recent research has developed physiological explanations for CQ’s traditional efficacy, including the reduction of pro-inflammatory cytokines, modulation of the glucocorticoid system (in animal trials), and the proliferation of osteoblast (bone-forming cell) DNA.\u003c\/p\u003e\n\u003cp\u003eSpecific to bone formation, there is strong data to suggest that CQ increases the accumulation of compounds known as mucopolysaccharides – long chain sugar molecules that precede mineralization in the process of bone formation. Think of these compounds sort of like the wet newspaper before it becomes paper mache. As stated, separate research also suggests that extracts of CQ stimulated osteoblastogenesis, the process of forming bone cells.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBlack cherry extract:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBlack cherry extract contains a number of beneficial compounds, including high levels of anthocyanin – an extremely potent anti-inflammatory compound which some animal evidence has shown plays a role in the maintenance of articular jointsIt is rich in antioxidants and catechins, chlorogenic acid, and flavonal glycoside, and has been used to support healthy uric acid levels typically associated with complete joint health.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTurmeric (95% curcumin):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eTumeric is a root endemic to certain regions of Southeast Asia and India, and has been a staple in the Siddha traditional medicinal system for thousands of years. Tumeric is noted in Siddha texts for various uses, including as an ancient equivalent of an anti-microbial agent.\u003c\/p\u003e\n\u003cp\u003eMore recently, numerous studies seem to suggest that its primary bioactive constituent, curcumin,  powerfully inhibits the enzymes that synthesize inflammatory compounds such as prostaglandins and leukotrienes. In particular, basic research and molecular studies have now firmly established curcumin’s ability to dose-dependently and potently inhibit a transcription factor known as NF–kB – a molecule involved in the proliferation of pro-inflammatory cytokines, soft tissue destruction, and autoimmune responses.\u003c\/p\u003e\n\u003cp\u003eThough Tumeric contains approximately 5% curcumin by weight, we have used a highly standardized extract of 95% - recognizing that the wealth of research on curcumin demands that it be included in clinical serving sizes.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBoswellia (37.5% boswellic acids):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBoswellia is a tree resin extract that is a traditional part of Indian medicine. In modern clinical trials the active agenct, boswellic acid, has been found to inhibit the production of pro-inflammatory leukotrienes. Similarly to curcumin, boswellic acids have demonstrated a significant attenuation of NF-kB production in various animal and \u003cem\u003ein vitro \u003c\/em\u003eassays.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBromelain (2400GDU\/g):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBromelain is a collection of protein-digesting enzymes found in pineapple juice and in the stem of pineapple plants. It has been shown to have a myriad of health benefits including speed of recovery, antioxidant properties, and assisting cardiovascular and circulatory health. The mechanism of the anti-inflammatory activity is not very well understood, but like curcumin and boswellia it appears to support inflammatory marker balance. Numerous studies have shown bromelain’s ability to assist and speed recovery time following various health related procedures.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin C:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVitamin C is not only a powerful antioxidant, but also supports a healthy immune system, protects cells from oxidized particles and free radicals, and assists other physiological functions. A major study by the University of California at Berkeley found that supplementing with 500 milligrams of Vitamin C (the daily serving contained in Core FLEX) led to a 24% reduction in levels of C-reactive protein, a consistent marker of inflammation. In conjunction with the other ingredients, it is important component of strong joints and overall health.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin D3:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVitamin D3 is an essential hormone precursor that plays a vital role in many metabolic functions, including bone health, , immune and cardiovascular health, muscle protein synthesis, and weight management. Although some foods contain Vitamin D3, the human body generates most of its Vitamin D3 needs from the skin through regular exposure to sunlight. Healthy and normal Vitamin D3 levels are essential to maintaining numerous bodily processes, including regulating the pro-inflammatory responses of joints and connective tissues to damage.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePiperine (95%)\u003c\/strong\u003e:\u003c\/p\u003e\n\u003cp\u003ePiperine a black pepper extract, is included because it dramatically increases the bioavailability of curcuminoids (see above). Without piperine, the serum concentration and absorption rates of the active agents in curcumin would be significantly reduced. Piperine facilities the full effects of the curcumin.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-FLEX-2020.jpg?v=1596180787\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_FLEX_8.5x3.25_FIN-OL.pdf?v=1638801046\" target=\"_blank\"\u003eCore FLEX Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core-FLEX-Product-References.pdf?6302103401660858656\" target=\"_blank\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":53256736047414,"sku":"672975009694","price":180.95,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/FLEX_FRONT_7fdf3a51-3f56-45c1-9e84-e4ea063557da.png?v=1762807499"},{"product_id":"core-vegan","title":"Vegan 2lb","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003eLactose, Soy, and Gluten Free\u003c\/li\u003e\n\u003cli\u003eGourmet Taste\u003c\/li\u003e\n\u003cli\u003eAdded Fermented Vegan BCAAs\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003ciframe height=\"315\" width=\"560\" src=\"https:\/\/www.youtube.com\/embed\/2RS_wcB2n7k\"\u003e\u003c\/iframe\u003e\u003c\/p\u003e\n\u003cp\u003eFinding balance for a vegan protein is difficult. Often, you are sacrificing either taste or a quality amino acid profile to achieve the other.\u003c\/p\u003e\n\u003cp\u003eCore VEGAN solves this problem. To ensure you receive a complete protein with every serving of our pea and brown rice protein blend, we add fermented vegan BCAAs to every scoop. To ensure maximum digestibility, we also add the digestive blend DigeSEB™, an exact mixture of amylases, lactase, proteases, lipase, and cellulase\u003c\/p\u003e\n\u003cp\u003eFinally, the taste. We get it: vegan proteins do not typically taste great. Core VEGAN does. We worked relentlessly to nail down a flavor profile and creamy texture that rivals any animal-based protein. Our testers called it the best-tasting plant-based protein on the market. Yes, that good.\u003c\/p\u003e\n\u003cp\u003eIn our space, the word “vegan” was once considered pejorative. No longer. An emerging consensus demonstrates that it is possible to combine vegan and athletic lifestyles, with purpose-built solutions allowing vegans to consume the necessary range of macro-and micronutrients. Vegan protein rose quickly to the fore. As those who follow a vegan diet or lifestyle cannot consume dairy, the traditional protein source of whey is closed off to them–resulting in a range of plant-based proteins. There was a problem, however: they tasted disgusting and felt even worse drinking\u003c\/p\u003e\n\u003cp\u003eWith Core VEGAN it is easy to hit your protein goals without choking down some leafy sludge. Our optimized blend of pea and brown rice proteins has an optimal amino acid profile far superior to any other plant protein source. To supplement these protein sources, we add fermented, vegan-friendly BCAAs– abundant in animal protein sources but often lacking in a strictly vegan diet. BCAAs are the powerhouse behind repair and recovery from the everyday labors that your body endures.\u003c\/p\u003e\n\u003cp\u003eOn top of our protein blend and BCAAs, we added DigeSEB™ – a complex blend of digestive enzymes to ensure optimal gut digestibility and nutrient absorption. While other vegan proteins may leave you bloated and gassy, DigeSEB™ helps eliminate this discomfort so you can enjoy your protein and benefit entirely from it too!\u003c\/p\u003e\n\u003cp\u003eIn all, Core VEGAN represents the elusive perfect balance for a plant-based protein: a complete protein source with \u003cstrong\u003eAMAZING TASTE\u003c\/strong\u003e and mouth feel. Compromise is no longer the “name of the game” with plant-based proteins.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePlant-based Protein Blend\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePea protein, being a nutritional powerhouse with unique benefits, is the backbone of Core VEGAN. Not only is pea protein one of the most complete plant protein sources, it also confers some unique benefits. One of these benefits is that it is derived from a source that is hypoallergenic, meaning it is a preferred protein source for those who have dietary restrictions. Pea protein is also rich in essential and branch chained amino acids, making it great for muscle building and recovery. An 8-week study made up of 15 participants showed that when consumed along with resistance training, pea protein elicits just as much muscle protein synthesis as its whey counterpart. When it comes to digestibility, 95-98% of the proteins in peas are digestible, which makes its absorptive properties optimal. The minimal processing that is done also removes the fibers and starches that can prolong digestion and reduce its absorptive properties.\u003c\/p\u003e\n\u003cp\u003eMuch like peas, brown rice is derived from a source that is hypoallergenic making it a great alternative for those with dietary restrictions, especially lactose intolerance. In studies when compared to whey, participants who also engaged in physical exercise exhibited similar responses in metrics that were measured. These included decreased soreness, improvements in power, increases in muscle mass, as well as decreases in body fat.\u003c\/p\u003e\n\u003cp\u003eTo summarize the qualities of these two complimentary protein sources, their benefits include:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eLow allergenic response and suitable for those with dietary restrictions.\u003c\/li\u003e\n\u003cli\u003eSimilar amino acid structure and muscle building response when consumed along with resitance training.\u003c\/li\u003e\n\u003cli\u003eHigh bioavailability and digestibility, reducing bloat and increasing protein delivery to tissues.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eVegan Coconut Oil Creamer\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMedium chain triglycerides are a form of fat with 6-12 carbon fatty acid esters, a chemical structure that allows them to effectively bypass gastric uptake for transport directly to the liver for oxidation. Their unusual chemical structure and metabolic process has resulted in MCTs being a focus for a wide range of therapeutic and exercise supplement uses.\u003c\/p\u003e\n\u003cp\u003eIn the context of exercise science, recent research has shown that MCTs significantly (up to 65%) increase resting energy expenditure, along with dose-dependently reducing fatty acid deposition in adipose tissue. These results suggest that MCTs are effectively increasing the body’s metabolic response to food intake.\u003c\/p\u003e\n\u003cp\u003eThis vegan coconut oil creamer also imparts a rich smoothness to this plant-based protein blend, giving it a pleasant mouthfeel unlike most vegan proteins on the market.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVegan BCAA\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eProteins have been talked about as being one of the most beneficial nutrients for your body when it comes to growth, maintenance, and support. But when we dive deeper into proteins, we discover that they are made up of their own building blocks called amino acids. When it comes to skeletal muscle, the BCAAs (Leucine, Isoleucine, and Valine) are the most important. These three separate amino acids single handedly influence the actions of muscles, including the rate at which muscle grows, its power output, its endurance, etc. Like we said before, even those following an animal free diet deserve gains too! We have added vegan BCAA, in the research-backed 2:1:1 ratio, to our Core VEGAN protein to fill in the gaps and help support the BCAA’s already found in the protein sources included. This makes for an internal environment that will help delay muscle soreness, decrease recovery times, as well as positively impact your body composition goals. To sum up what a large body of evidence has already exhibited, BCAA can:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eDelay\/reduce the onset of muscle soreness after intense exercise.\u003c\/li\u003e\n\u003cli\u003eDecrease muscle recovery time between bouts of intense resistance exercise training.\u003c\/li\u003e\n\u003cli\u003ePositively impact body composition when combined with proper diet and exercise.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDigeSEB™\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWe know that digestion and absorption is an extremely important, and often overlooked property of many diets. Digestive enzymes are then equally overlooked and forgotten when it comes to a supplementation regimen. These powerful little protein structures influence many complex processes that occur within our bodies. In a fitness-specific context, digestive enzymes play an absolutely crucial role in the breakdown of dietary carbohydrates, fats, and proteins into their constitutive parts, and therefore allow your body to use them in various processes (glycogenesis, protein synthesis, etc).\u003c\/p\u003e\n\u003cp\u003eAs you have probably seen by now, we here at Core Nutritionals do not cut corners. Like our whey blend counterpart Core PRO, we have added the comprehensive and clinically proven benefits of digestive enzymes into Core VEGAN. DigeSEB™ is comprised of amylases, proteases, lactases, amylases, and cellulases, allowing for a full and complete breakdown of every component.\u003c\/p\u003e\n\u003cp\u003eDigeSEB™ ensures that Core VEGAN not only tastes great but also increases the effectiveness of your pre- and post-workout nutrition in general.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-VEGAN-REV_ea443a0f-ecef-455d-8b0e-291176ea3c59.jpg?v=1603103280\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_VEGAN-BROWNIE-FIN-OL_compressed.pdf?v=1644225517\"\u003eChocolate Brownie Batter Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_VEGAN-PANCAKE-FIN-OL_compressed.pdf?v=1644225651\"\u003eMaple Pancake Batter Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_VEGAN-PB_PIE-FIN-OL_compressed.pdf?v=1644225714\"\u003ePeanut Butter Pie Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_VEGAN-VANILLACREME-FIN-OL_compressed.pdf?v=1644225795\"\u003eVanila Cream Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_VEGAN_Frosted_Cinnamon_Bun_FIN-OL.pdf?v=1649831324\"\u003eFrosted Cinnamon Bun Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_VEGAN_Strawberry_FIN-OL.pdf?v=1649831324\"\u003eStrawberry Cream Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/REFFERENCES_-_VEGAN.pdf?v=1592810779\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Peanut Butter","offer_id":53256736604470,"sku":"672975315603","price":228.57,"currency_code":"AED","in_stock":true},{"title":"Strawberry","offer_id":53256736637238,"sku":"658580070649","price":228.57,"currency_code":"AED","in_stock":true},{"title":"Chocolate Brownie","offer_id":53256736670006,"sku":"672975009892","price":228.57,"currency_code":"AED","in_stock":true},{"title":"Vanilla Cream","offer_id":53256736702774,"sku":"672975315818","price":228.57,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/VEGAN3FRONT_a11b73c5-fe11-440b-866d-b63040c478f5.png?v=1762807503"},{"product_id":"core-hard","title":"Hard","description":"\u003cp\u003eBenefits of Core HARD may include the following:  \u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eKSM-66®\u003c\/strong\u003e - Reduction in cortisol levels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDIM\u003c\/strong\u003e - Regulate healthy estrogen production\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eL-Theanine\u003c\/strong\u003e - Increased measures of well being\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eYour diet is impeccable and couldn’t be any more in check – macros, micros, you have it all down. Your workouts? Get out of here! You have slaved, grinded, and grunted your way through leg workouts so intense the gym staff cried – and those were on your worst days. And yet, something is missing.\u003c\/p\u003e\n\u003cp\u003eIt’s that “extra” level of shred, “that look.” You know exactly what we mean. That type of leanness and density that makes an arm look twice as big, a stomach look twice as lean, and a forearm look like a roadmap for the Italian countryside. It’s that kind of elusive hardness that’s so rare, most of us simply chalk it up to genetics, or luck, or steroids, or whatever excuse we have handy – and yet we all still want it.\u003c\/p\u003e\n\u003cp\u003eThe reality is that it isn’t all that unattainable. Getting “that” look, “that” hardness, is about hormonal balance, optimization and body recomposition. It’s a matter of adding in that final piece of the puzzle that makes the entire picture come out perfectly.\u003c\/p\u003e\n\u003cp\u003eTo be hard, you need to get HARD. It’s that simple.\u003c\/p\u003e\n\u003cp\u003eCore HARD is another product in the Core Nutritionals’ lineup to follow the basic, but indispensable principles that Core Nutritionals is slowly making an industry standard: create products with effective ingredients, in effective doses, in a non-proprietary formula. This time around, we have applied those principles to the problem of softness that we all despise and have developed the most advanced ultra-hardening and recomposition agent on the market.\u003c\/p\u003e\n\u003cp\u003eTaking advantage of both the old and the new, Core Nutritionals has employed both modern, cutting-edge compounds and traditional herbs to create a balanced approach to delivering hardness. Key ingredients in Core HARD affect some of the body’s critical physiological pathways, combining sexiness and science in a single, non-proprietary formula. We have included five powerful ingredients into a full month's worth of stimulant free, recomposition goodness. The result? Reduced cortisol levels, healthy estrogen and hormone regulation, weight loss and lean muscle growth, increased measures of well-being, improved athletic performance, stamina and power.\u003c\/p\u003e\n\u003cp\u003eCore HARD can be used alone, or in a stack with other Core Nutritionals’ products. The BURN HARD stack (Core HARD plus \u003ca href=\"https:\/\/www.corenutritionals.com\/products\/core-burn-powder\" title=\"Core BURN - Stimulant Thermogenic\" target=\"_blank\"\u003eCore BURN\u003c\/a\u003e) will be the ultimate fat blasting and hardening stack. Men can try the HARD A.B.s stack (Core HARD plus \u003ca href=\"https:\/\/www.corenutritionals.com\/products\/core-alpha\" title=\"Core ALPHA - All Ultra Potent Natural Hormone Optimizer\" target=\"_blank\"\u003eCore ALPHA\u003c\/a\u003e and \u003ca href=\"https:\/\/www.corenutritionals.com\/products\/core-burn-powder\" title=\"Core BURN - Stimulant Thermogenic\" target=\"_blank\"\u003eCore BURN\u003c\/a\u003e) to help create that chiseled look that all men want.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhysiological Properties and Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhosphatidylserine (50%)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePhosphatidylserine, colloquially known as PS, is a nearly ubiquitous phospholipid found in various membranous tissues throughout the body. PS’s ubiquity coincides with its necessity for crucial physiological functions, as the phospholipid is implicated in several components of cell communication, as well as the mediation of catecholamine synthesis and transmission in the brain (along with other neuroendocrine functions). In a fitness-related context, a nascent but growing body of methodologically-sound research suggests that PS may play a role in increasing exercise capacity.\u003c\/p\u003e\n\u003cp\u003eStudies administering the compound in both acute and chronic fashion suggest that PS has a measurable effect on exercise capacity. In a double-blind, placebo-controlled, randomized trial involving 16 trained athletes, phosphatidylserine was administered for 10 days prior to an acute exercise challenge. Exercise markers such as exercise time to exhaustion, sprint performance, and ratings of perceived exertion, were measured post-exercise. The authors found that exercise time to exhaustion was significantly altered. Related studies using similar serving sizes have found that chronic PS administration increased shot accuracy in golfers, increased exercise time to exhaustion by 28% in cyclists, and reduced subjective feelings of stress and soreness in others.\u003c\/p\u003e\n\u003cp\u003eOverall, phosphatidylserine appears to play a valuable role in the increase in exercise capacity. PS may therefore play a critical role in the continued exercise success of bodybuilders in a, “cutting” or recomposition stage.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eKSM-66® Full-spectrum Ashwagandha root extract (5% Withanolides)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eWithania somnifera Dunal\u003c\/em\u003e, colloquially known as Winter Cherry or Indian Ginseng, is an herb that features prominently in the traditional Indian medicinal system of Ayurveda. Known as Ashwagandha in Ayurveda, \u003cem\u003eWithania somnifera\u003c\/em\u003e is a critical ingredient in various Ayurvedic tonics and tinctures prepared as a traditional remedy for the treatment of various ailments.\u003c\/p\u003e\n\u003cp\u003eRecently identified as a potent adaptogenic and target for therapeutic applications, Ashwaghanda has been the subject of numerous animal, pre-clinical, and clinical trials designed to examine its potential effects as an antioxidant, anti-carcinogenic, anxiolytic, antibacterial, antifungal, and immonumodulating compound. Ashwaghanda’s broad therapeutic potential is hypothesized to be the result of its robust phytochemical profile, including a wide swath of alkaloids, sitoindosides, and the highly biologically active withanolide group. As the principally biologically active compounds within Ashwaghanda, withanolides such as withanone, withaferine A, withanolides A, D, and G have been identified, isolated, and extensively studied in the various applications noted above.\u003c\/p\u003e\n\u003cp\u003eIn recognition of the potential physiological benefits of withanolides, Core Nutritionals selected KSM-66® to include in its HARD formula. KSM-66® is a full-spectrum Ashwaghanda extract, standardized for 5% withanolides – meaning that KSM-66® not only includes the full range of biologically active compounds within Ashwaghanda, but also that it contains the highest currently available concentration of the principally active withanolides (5%).\u003c\/p\u003e\n\u003cp\u003eThe high concentrations of withanolides within KSM-66® has resulted in encouraging results in a number of human, clinical trials – particularly considering many of these trials were conducted using the methodological gold standard of randomization, double-blind delivery, and placebo control. Amongst the most impressive results contained in these trials:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eA 27.9% reduction in serum cortisol levels, measured over 60 days in a trial featuring 64 chronically stressed adults.\u003c\/li\u003e\n\u003cli\u003eStatistically significant increases to endurance and stamina, as measured by VO2 max, in a clinical trial featuring 50 healthy, exercise-trained adults.\u003c\/li\u003e\n\u003cli\u003eIncreased measures of well-being as reported by self-assessment scales, included in both the clinical trials mentioned above.\u003c\/li\u003e\n\u003cli\u003eStatistically significant increases in serum testosterone levels in a clinical trial featuring 68 infertile men.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThough each of these results is impressive, perhaps the most significant is the 27.9% reduction in cortisol seen in the 60 day trial. As detailed above, cortisol possesses a multitude of potentially degradative physiological effects, including: inhibiting glucose uptake, causing a constriction of the vasculature (vasoconstriction), the breakdown of glycogen, and inarguably the result most would desire to avoid, proteolysis (the breakdown of muscle tissue).\u003c\/p\u003e\n\u003cp\u003eTo put it the simplest way possible, cortisol’s chief functions involve either turning on, or shutting off, the very things we as fitness enthusiasts want to avoid or turn on, respectively!\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eForsLean® (Coleus forskohlii) (std. to 10% forskolin)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eForsLean® is a patented, clinically studied extract of Coleus forskohlii root, standardized to 10% forskolin. Its popularity withing the fitness and sports nutrition world stems from its unique ability to aid in body recomposition—specifically by helping to increase lean body mass while reducing overall fat mass.\u003c\/p\u003e\n\u003cp\u003eOne of the most cited studies supporting ForsLean’s® efficacy was published in Obesity Research (2005) by Godard et al. In this 12-week, randomized, double-blind, placebo-controlled study, 30 overweight and obese men were given either 250 mg of 10% forskolin extract twice daily or a placebo. The forskolin group compared to placebo experienced:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eSignificantly greater reductions in body fat percentage and fat mass.\u003c\/li\u003e\n\u003cli\u003eNotable increases in lean body mass\u003c\/li\u003e\n\u003cli\u003eNotable increases in serum free testosterone levels.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThese results suggest ForsLean® may support muscle preservation or growth while also aiding fat loss, which is an ideal outcome for anyone looking for body recomposition.\u003c\/p\u003e\n\u003cp\u003eThe mechanisms behind ForsLean’s® effects are believed to stem from the active compound, forskolin’s, ability to activate adenylate cyclase, which can increase cyclic AMP (cAMP) levels. Elevated cAMP stimulates hormone-sensitive lipase and other enzymes involved in fat breakdown while potentially enhancing thyroid function and testosterone production—both of which are tied to metabolism and muscle retention.\u003c\/p\u003e\n\u003cp\u003eAnother study published in the Journal of the International Society of Sports Nutrition (2005) by Henderson et al. found that 250 mg of ForsLean® taken twice daily for 12 weeks in mildly overweight women resulted in a trend toward reduced weight gain and fatigue, along with preserved lean mass. Although the results were not as dramatic as in the male cohort, the study still supports ForsLean’s® use in maintaining body composition during calorie restriction or weight loss.\u003c\/p\u003e\n\u003cp\u003eIn summary, ForsLean® stands out among natural ingredients for body recomposition due to its ability to simultaneously promote fat loss and preserve or enhance muscle mass—especially when paired with resistance training and proper nutrition.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e3,3'-Diindolylmethane (DIM)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWhat we typically refer to as “Estrogen,” is in fact a group of three biologically distinct hormones – estradiol (E2), estrone (E1), and estriol (E3), each possessing different activities in different cell, tissue, and receptor types. When experts refer to either the benefits or downfalls of “estrogen,\" they really mean to (but probably cannot) identify \u003cem\u003ea specific\u003c\/em\u003e estrogen.\u003c\/p\u003e\n\u003cp\u003eThese \u003cem\u003especific estrogens\u003c\/em\u003e, in turn, metabolize into even more specific estrogen sub-compounds, such as the 2-hydroxyestrogens (2-OHE’s), 2-methoxyestrogens, 16a-hydroxyestrone (16-OHE1), and 4-hydroxyestrogens (4-OHE’s). As their parent estrogens, these estrogen metabolites exert different effects depending upon the tissue and cell one is examining. In fact, two estrogen metabolites in particular, 16-OHE1 and 2-OHE, have such contrasting cellular activities that 2-OHE is an \u003cem\u003eestrogen antagonist\u003c\/em\u003e. Yes, that is correct: there is an anti-estrogen, estrogen.\u003c\/p\u003e\n\u003cp\u003eIn recent years, so-called “phytonutrients” have become the focus of clinical research, as these natural compounds have shown the ability to increase the ratio of good, estrogen decreasing estrogens (such as 2-OHE), to bad, estrogen increasing estrogens (such as 16-OHE1). One of these phytonutrients, a dietary indole known as indole-3-carbinol (I3C), is the bioactive phytochemical and a presumed modulator of reduced cancer risk in areas with high cruciferous vegetable consumption. Unfortunately, despite its potent antiestrogenic activity, I3C is highly molecularly unstable, and therefore unsuitable for use as a therapeutic agent or dietary supplement.\u003c\/p\u003e\n\u003cp\u003eLuckily, however, I3C readily metabolizes into the secondary indole 3,3’ diindolylmethane, or DIM for short. When used in a supplemental fashion in clinical trials, DIM appears to possess all the positive effects of its parent compound with respect to antiestrogenic action – promoting the metabolism of beneficial estrogens that themselves reduce estrogenic activity.\u003c\/p\u003e\n\u003cp\u003eAside from its healthy-estrogen promoting abilities, DIM also exerts its own direct physiological effects, including:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003ePromoting pathways of internal estrogen metabolism that favour the production of anti-estrogen estrogens.\u003c\/li\u003e\n\u003cli\u003eAdjusting the activity of certain cytochrome enzymes, reducing the activity at the estrogen receptor site.\u003c\/li\u003e\n\u003cli\u003eLimit the cell division and growth of certain estrogens.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eDespite the bodybuilding community’s single-minded crusade to eliminate estrogen wherever it lie in wait, compounds such as DIM show us that estrogen is a very diverse set of compounds – and that we should actively pursue increasing certain estrogens that have beneficial, and ironically, anti-estrogenic effects\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eL-Theanine\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThough the literature surrounding L-theanine is still emerging, the amino acid is slowly building a reputation as one of the most interesting and exciting compounds being targeted for therapeutic use. L-theanine is an amino acid found almost exclusively in tea, constituting approximately 1-2% of the dry weight of tea – resulting in a 25–60 mg theanine load per 200 ml serving of liquid tea.\u003c\/p\u003e\n\u003cp\u003eFirst identified in green tea and in the mushroom \u003cem\u003eXerocomus badius\u003c\/em\u003e, L-theanine readily crosses the blood-brain barrier in a dose-dependent manner, and it is thought to influence the central nervous system (CNS) through a variety of mechanisms, including:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eIncreasing the release and concentration of dopamine.\u003c\/li\u003e\n\u003cli\u003eInhibiting glutamate reuptake and blockade of glutamate receptors in the hippocampus.\u003c\/li\u003e\n\u003cli\u003eIncreasing gamma-aminobutyric acid (GABA – a neurotransmitter associated with the regulation of responses) concentrations.\u003c\/li\u003e\n\u003cli\u003eIncreasing levels of serotonin.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eIn addition to these more well-demonstrated effects, emerging electroencephalography trials on theanine suggest that the amino acid may exert a positive effect on alpha waves – a type of brain wave implicated in restful relaxation. Alpha activity has also been associated with increased creativity, increased performance under stress, and improved learning and concentration, as well as decreased anxiety.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/HARD_NEW.png?v=1753093928\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/HARD_LABEL_1.png?v=1753093978\"\u003eCore HARD Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core_HARD_2025_References.docx?v=1753096766\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":53256736768310,"sku":"850057789515","price":209.52,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/HARD_FRONT_e845516d-efdd-44a6-a02c-effc7ce8ad25.png?v=1762807503"},{"product_id":"core-multi","title":"Multi","description":"\u003ch2 class=\"slogan\"\u003e\u003cbr\u003e\u003c\/h2\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eFull daily serving (or more) for most key vitamins and minerals\u003c\/li\u003e\n\u003cli\u003eVeggie caps for enhanced absorption\u003c\/li\u003e\n\u003cli\u003eSpectra anti-oxidant blend\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003ciframe height=\"315\" width=\"560\" src=\"https:\/\/www.youtube.com\/embed\/tNZJTWhYbOA\"\u003e\u003c\/iframe\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFull Spectrum Multivitamin and Mineral\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eVegetable Caps\u003c\/li\u003e\n\u003cli\u003eEnhanced Absorption\u003c\/li\u003e\n\u003cli\u003eEfficacious Servings\u003c\/li\u003e\n\u003cli\u003eNo Proprietary Blends\u003c\/li\u003e\n\u003cli\u003eGluten Free\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNailing a completely balanced diet every day, one that contains the full spectrum of essential and non-essential vitamins and minerals alike, would be amazing. It would be even better if everyone did that. In that case, the often-quoted but little understood claim of many “gurus” that a vitamin supplement is unnecessary would be correct.\u003c\/p\u003e\n\u003cp\u003eBut that’s not the case, not at all. In fact, research shows that most people – yes, even you, the fit person reading this – do not eat a balanced diet. Many people lack critical nutrients from their diet, either by absence (not eating them at all) or by over- or under-consuming other trace minerals or vitamins necessary for the original vitamin’s homeostasis. The result, in either case, is a vitamin and mineral environment that could and can be optimized.\u003c\/p\u003e\n\u003cp\u003eFor that reason, we’ve formulated Core MULTI. Like the typical diet, when we looked around the industry at existing multi-vitamin offerings, we found critical defects: too much of this, too little of that, and so on. So, we set out to alter that arrangement and formulate a multi with ingredients included in specific proportions to maximize synergy and minimize redundancy.\u003c\/p\u003e\n\u003cp\u003eThe result is a formula not only with 100% (and often more) of almost all your essential vitamins and minerals, but also a broad-spectrum antioxidant blend antioxidant blend (Spectra™), berberine HCL, and numerous trademarked forms of vitamins and minerals. If you need a broad range of essential vitamins and minerals in sufficient amounts and in the most efficient forms, then Core MULTI is for you.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eB Vitamins (Thiamine, Riboflavin, Niacin, B6 [Pyridoxine], Folic Acid, B12, Biotin, and Pantothenic acid)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eB vitamins are a group of eight essential vitamins with several critical functions in the body. Though both molecularly and physiologically distinct, they are also deeply interrelated in their effects, synthesis and metabolism. Among the B-complex’s many critical roles are energy (protein, carbohydrates, and fat) metabolism, supporting and maintaining the healthy function of the adrenal glands, skeletal muscle function, and digestion.\u003c\/p\u003e\n\u003cp\u003eWhile rates of metabolism and clearance differ between each B vitamin, all B vitamins are water-soluble and are thus not stored in fat. As a result, the body simply excretes excess B vitamins in the urine and requires replenishment (from food or supplements) in order to maintain the cell functions to which B vitamins contribute.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin A (as Beta Carotene)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBeta carotene is itself not an essential vitamin but is rather the precursor to the fat-soluble and essential vitamin, vitamin A (Retinol). Like B vitamins, the term vitamin A refers to the compound class retinoids, comprised of retinol, retinal (also called retinaldehyde), retinoic acid, and provitamin A compounds such as beta carotene.\u003c\/p\u003e\n\u003cp\u003eAs their names suggest, retinoids are critical to the function of human eyes and therefore to the maintenance of circadian rhythms (our “biological clock”). Vitamin A combines with proteins in the eye to form light-sensing cells that both facilitate vision and regulate our sleep-wake cycles.\u003c\/p\u003e\n\u003cp\u003eBeyond its role in sight, vitamin A is also essential for cellular growth and differentiation and the immune system.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin C (as Ascorbic Acid)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVitamin C is perhaps historically best-known for the treatment and prevention of scurvy, though it has many other roles in the body. For example, vitamin C catalyzes or is a cofactor in eight enzymatic reactions involved in the synthesis of collagen, the nutrient carnitine, and several neurotransmitters necessary for the proper function of the brain.\u003c\/p\u003e\n\u003cp\u003eIn the contemporary context, vitamin C is best known as a potent antioxidant. In addition to its intrinsic activity as an antioxidant, vitamin C has been shown in in vitro trials to regenerate alpha-tocopherol (vitamin E). As an antioxidant, vitamin C combats the detrimental effects of a group of compounds called radical oxygen species that, when produced, degrade the lipid membrane of the cell and may cause internal damage. By “scavenging” these free radicals, vitamin C and other antioxidants form a defense against excess cellular damage.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin D3 (as Cholecalciferol)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVitamin D, in its various forms, is not an essential nutrient – as it is produced endogenously within the body, as a reaction to the skin’s exposure to the sun – and thus not commonly considered a vitamin. Despite its technical classification, vitamin D (a hormone), is nevertheless an import and biologically-active compound, necessary for the calcium homeostasis and metabolism, along with increasing the absorption of magnesium and phosphate.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin E (as Mixed Tocopherols) \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVitamin E is another technical misnomer, as the term refers to a group of compounds known as tocopherols with eight biologically-active constituents: alpha-, beta-, gamma-, and delta-tocopherol and alpha-, beta-, gamma-, and delta-tocotrienol. Alpha-tocopherol is the principal bioactive in humans, though the presence of other tocopherols has been linked to beneficial effects.  \u003c\/p\u003e\n\u003cp\u003eAs a result of its robust antioxidant activity, vitamin E assists in the maintenance and support of several physiological processes, though most notably sight and the immune system. Emerging research also suggests that the alpha-tocopherol form of vitamin E inhibits an enzyme known as protein kinase C, and therefore contributes to the healthy regulation of smooth muscle cell growth and differentiation.\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eCritically, we have used the natural version of vitamin E (technically d-alpha tocopherol) and not the synthetic (dl-alpha tocopherol). The difference is a meaningful one: the single isomer of d-alpha tocopher\u003c\/span\u003e\u003cspan\u003eol is easier and more efficiently absorbed and used in the body as compared to the eight isomers in the dl analog.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCalcium (as Calcium Carbonate) \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWhile best-known as the main bioactive in milk, and a compound that contributes to strong bones, calcium has numerous physiological effects in the body – including mediating vascular contraction and vasodilatation, muscle function, nerve transmission, intracellular signaling, and hormonal secretion. Homeostatic regulation of calcium, which the body cannot produce, requires sufficient levels of vitamin D.\u003c\/p\u003e\n\u003cp\u003eWhen present in sufficient amounts, calcium is necessary for the adequate formation, function, and remodeling of both bone and teeth. Insufficient levels of calcium are associated with degenerative bone and joint disorders such as osteoporosis, wherein bone accretion slows or stops; thereby reducing bone mass and density and decreasing bone strength.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIodine (As Kelp (Ascophyllum nodosum))\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIodine is a trace element naturally present in certain foods, including kelp. Iodine is a critical component for fetal development, especially during early pregnancy, as maternal T4 (thyroxine) is the sole source of fetal thyroid hormone. After birth, especially if breast-feeding, iodine remains an important constituent of a balanced-diet to maintain adequate T3 (triiodothyronine) and T4 (thyroxine) levels in the mother and for the proper cognitive development in the child.\u003c\/p\u003e\n\u003cp\u003eAs implied, however, the most important of iodine’s functions is assisting the body to produce and maintain healthy levels of both thyroid hormones and TSH (thyroid stimulating hormone, released by the pituitary). The thyroid hormones, in turn, regulate several critical biochemical reactions, including protein synthesis, and, along with norepinephrine\/epinephrine, largely determine the body’s metabolic rate.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMagnesium (as Albion® Di-Magnesium Malate)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIt is difficult to overstate the biological necessity of magnesium. Magnesium is a co-factor in over 300 enzymatic reactions that regulate essential physiological functions such as protein synthesis, glucose homeostasis, muscle and nerve function, and the maintenance and support of healthy blood pressure levels.\u003c\/p\u003e\n\u003cp\u003eMagnesium is also required for the use of the body’s energy currency, ATP. To become biologically active, ATP must be bound to magnesium to form Mg-ATP. In addition, magnesium is necessary for the proper function of cells with calcium and potassium gated ion channels such as heart and muscle cells.\u003c\/p\u003e\n\u003cp\u003eIn men, magnesium (along with zinc) is necessary for the maintenance of healthy levels of testosterone.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eZinc (as Zinc Aspartate) \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAs an essential mineral, like magnesium, zinc is also involved in a wide-range of essential biological functions in the human body – and a requirement in the catalytic activity of over 100 enzymes.\u003c\/p\u003e\n\u003cp\u003eMost notably, zinc is vital for immune function, protein synthesis, cellular division, and DNA synthesis. For immune function, zinc is required for the function of a group of immune cells known as neutrophils and macrophages, which eliminate pathological cells and their products from the body.\u003c\/p\u003e\n\u003cp\u003eWith magnesium, sufficient levels of zinc are also necessary for the production and maintenance of healthy levels of testosterone.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCopper (as TRAACS® Copper Bisglycinate Chelate)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCopper is a trace element necessary for the production, function, and maintenance of a diverse range of compounds involved in physiological function.\u003c\/p\u003e\n\u003cp\u003eThe brain, the heart, bone, and connective tissue specifically require copper or the enzymes it catalyzes to properly grow and differentiate their various cell types. Like many of the ingredients in Core MULTI, copper is also required for the homeostasis of other minerals, specifically zinc.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eManganese (Manganese Citrate) \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eManganese is a required element for not only humans, but all living organisms. Manganese primarily acts as an antioxidant, specifically scavenging a radical oxygen species known as superoxide.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eChromium (as Chromium Picolinate)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eChromium is an essential, though little understood, trace element found in certain foods and industrial compounds. Only one of chromium’s two forms, the form used in Core MULTI, chromium 3+, is biologically active.\u003c\/p\u003e\n\u003cp\u003eWhile not as well-defined as other trace elements, chromium’s physiological actions nevertheless seem pivotal to the production and transmission of healthy levels of insulin. Emerging research also seems to suggest that chromium is directly involved in the metabolism of carbohydrates.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMolybdenum (as TRAACS® Molybdenum Glycinate Chelate)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMolybdenum is an essential trace element, involved in at least four enzymatic reactions necessary for urea excretion and a number of other physiological functions.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBerberine HCL\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThere is extensive literature demonstrating that berberine is a potent AMPk agonist in skeletal muscle. Based on the pharmacological similarities between berberine and the anti-diabetic medicine metformin (with respect to AMPk activation), it is possible that berberine may promote an anti-catabolic state through increased expression of AMPk. \u003c\/p\u003e\n\u003cp\u003eThe human data – in both healthy and disease state populations – demonstrating berberine’s other physiological effects are numerous. A 2012 meta-analysis examined 14 randomized trials, containing 1068 patients, and assessed berberine’s efficacy in numerous biometrics, including resting plasma glucose levels, plasma insulin levels, body weight, body mass index, and reduction in fat mass and serum triglycerides and total cholesterol content. The aggregate data suggests that berberine performs at least as well as oral hypoglycemic agents (such as metformin) in these key metrics.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBoron Citrate \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBoron is a mineral present in multiple fruits, vegetables, tubers, and drinking water, though it is not widely accepted as either an essential mineral or essential vitamin. Boron affects a few physiological functions in the body, particularly modulating hormonal homeostasis.\u003c\/p\u003e\n\u003cp\u003eWhile still emerging, recent data suggest that boron may play a role in potentiating free testosterone levels in even healthy men. In one study, otherwise healthy men were provided an acute serving of boron and had their free and total levels of testosterone, alone with SHBG (sex hormone binding globulin) and DHT (dihydrotestosterone) levels measured. In that study, total testosterone was unaltered, but free testosterone was enhanced by 14%, while SHBG was significantly (9%) reduced.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCholine (as Choline Bitartrate) \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e Choline is an essential nutrient involved in numerous metabolic pathways, including DNA regulation and repair, protein function, and metabolism. Perhaps most importantly, the critical neurotransmitter acetylcholine is produced directly from free choline via cholinergic neurons. Acetylcholine is then responsible for a number of functions itself, most crucially as the compound which induces muscular contraction, and as the neuromodulator partially responsible for modulating risk\/reward, arousal, and enhancing memory.\u003c\/p\u003e\n\u003cp\u003eCholine’s essential role as a substrate for acetylcholine, and therefore brain development, is well documented in animal models. These studies demonstrate that levels of free maternal choline have a direct and fundamental impact on prenatal brain development, with the enhancements or deficits lasting into adulthood. Choline’s enhancing effect is particularly prominent in the hippocampus. In humans, the hippocampus is primarily involved in the consolidation of memory (taking short, episodic memory and translating it into long-term memory) and the learning of new information. Acetylcholine is a critical component in these processes, as mentioned above, and choline may therefore play a potential role in these processes as well by providing the substrate for acetylcholine synthesis.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpectra™\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSpectra™ is the first scientifically validated formula of fruits, vegetables, and herbs shown to inhibit free radical production, optimize cellular metabolic activity, and increase nitric oxide levels within our bodies\u003c\/p\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 46.1255%; text-align: center;\"\u003e\u003cimg style=\"float: none;\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/science_multi_1.jpg?v=1532337742\" alt=\"\"\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 51.2915%; text-align: center;\"\u003e\u003cimg style=\"float: none;\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/multi_science_2.jpg?v=1532337813\" alt=\"\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eSpectra™ represents the latest evolution in the fight against potentially-damaging free radicals. For the first time anywhere, the biological effects of a natural supplement on the changes of oxidative and nitrosative stress markers, as well as cellular metabolic activity, have been clinically observed in the human body. Spectra™ has been reported to decrease ROS, increase cellular oxygen consumption in blood and mitochondria, decrease extracellular H2O2, and reduce TNFα-induced inflammatory response in humans.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-MULTI-2020.jpg?v=1585646276\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_MULTI_8.5x3.25_FIN-OL.pdf?v=1639556211\"\u003eCore MULTI Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core_MULTI_Product_Refferences.pdf?16007690605497637436\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":53256737390902,"sku":"672975009717","price":133.33,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/MULTIFRONT_78f01fa4-821d-4795-8467-6421a8fa6908.png?v=1762807508"},{"product_id":"core-alpha","title":"Alpha","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eN-methyl-D-aspartic acid (NMDA)\u003c\/strong\u003e - Supports healthy testosterone levels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e3-desoxy, 7-keto-DHEA\u003c\/strong\u003e - Supports healthy estrogen levels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eColeus forskohli root extract\u003c\/strong\u003e - Assists in healthy weight management\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"color: #9c0c30;\"\u003e\u003cstrong\u003eIngredients in this product are not WADA approved. Do not take if you are tested by WADA standards. \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eUnleash your inner ALPHA male with the ultra-potent Core ALPHA!\u003c\/p\u003e\n\u003cp\u003eCore ALPHA is an all-natural, innovative product featuring ingredients backed by numerous clinical studies. Core ALPHA’s ingredients are all-natural and powerful, providing a safe and effective way to support healthy hormone function and balance.\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e2 capsules per serving.\u003c\/li\u003e\n\u003cli\u003e28 servings per container.\u003c\/li\u003e\n\u003cli\u003eHormone balance.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eCore Nutritionals has been known to produce some of the best healthy hormone support supplements on the market. Our extensive in-house research and multiple blood analyses utilizing our own formulations have indicated significant improvements in all studied metrics over an 8-week trial period. Core Nutritionals natural hormone support arsenal includes products to help you manage and adapt to stresses, support healthy testosterone, as well as improve overall quality of life. To add to that arsenal, Core Nutritionals is proud to present to you Core ALPHA!\u003c\/p\u003e\n\u003cp\u003eCore ALPHA is an all-natural, innovative product featuring ingredients backed by numerous clinical studies. Core ALPHA’s ingredients are not only all-natural but powerful – providing a range of ingredients to support healthy hormone function and balance. As with all Core Nutritionals’ products, Core ALPHA’s ingredients are included in a non-proprietary blend featuring clinical servings, so you know exactly what you are supplementing.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eUnleash your inner ALPHA male with the ultra-potent Core ALPHA!\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eScientific breakdown:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eN-methyl-D-aspartic acid (NMDA):\u003c\/strong\u003e D-aspartic acid (DAA) is an amino acid that is found naturally in several endocrine glands, including the testes and pituitary. While the correlation between DAA and testosterone production has been clinically documented, research indicates several possible mechanisms for these effects. It’s likely that DAA acts as a neuromodulator influencing several pathways that govern the reproductive system, particularly testosterone production. Some studies indicate that DAA’s concentrated presence in the hypothalamus, pituitary, and testes identify this protein as an up-regulator of gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), growth hormone (GH), and testosterone. Some studies have found that DAA also stimulates a protein called StAR. StAR is necessary for the cholesterol transport in the cell that is needed for testosterone production. Further, its role in modulating the sexual drive implicates DAA assists nootropic activity, supporting healthy levels of dopamine and serotonin. Balanced levels of dopamine and serotonin have a range of significant benefits.\u003c\/p\u003e\n\u003cp\u003eTo improve on D-aspartic acid we have instead incorporated N-methyl-D-aspartate (NDMA) into the Core ALPHA formula. DAA is converted into NMDA, which is a potent stimulator of the N-methyl-D-aspartate receptor pathway. By directly stimulating this pathway, NMDA is needed only in small doses unlike DAA’s higher dose requirements. In fact, NMDA elicits its hormone releasing action at concentrations approximately 100-fold lower than DAA. Thus, at a 30 mg dose, NMDA, shows promise to support an optimal balance of hormones.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBrassaiopsis glomerulata leaf extract (10:1):\u003c\/strong\u003e Brassaiopsis glomerulata is a large shrub of the Araliaceae family that occurs in south and Southeast Asia. Throughout Asia, this plant is used to treat rheumatism and back pain, aid in digestion, and treat bone fractures in traditional medicinal systems (TMS). Despite its many medicinal uses, the most interesting aspect of the leaves of Brassaiopsis glomerulata is their ability to reduce the activity of aromatase. Studies show that multiple components of a Brassaiopsis glomerulata leaf extract are capable of aromatase inhibition. The addition of this 10:1 extract in Core ALPHA, along with the 3D7K, gives this product a one-two punch at supporting a healthy estrogen balance.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMucuna pruriens seed extract (50% L-dopa):\u003c\/strong\u003e Mucuna pruriens is one of the popular medicinal plants of India and is known to contain various beneficial nutritional compounds. The main nutrient found in Mucuna pruriens is L-dopa, which acts as a natural source of dopamine. Prolactin is a hormone released by the pituitary gland, which is believed to exert anti-androgenic effects in men.. Mucuna pruriens’ ability to support healthy dopamine levels may significantly reduce the release of prolactin hormone by the pituitary glands offering powerful benefits. In addition, clinical evidence suggests that Mucuna pruriens not only supports healthy growth hormone levels but also contains naturally occurring serotonin precursors to support mood, memory, and overall well-being. Clinically shown to support optimal balance of growth hormone, prolactin, serotonin and other beneficial hormones, Mucuna pruriens may also assist healthy weight management and stress support.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin D3 (cholecalciferol):\u003c\/strong\u003e Vitamin D3 is an essential hormone precursor that plays a vital role in many metabolic functions, including bone health, , support for immune and blood pressure health, lean body mass, and weight management). Clinical trials have even linked Vitamin D3 with an increase in overall health and well-being. Although some foods contain vitamin D, the human body generates most of its vitamin D needs from the skin through regular exposure to sunlight. Severe vitamin D deficiency is a significant and widespread problem, especially in North America. In addition to its well-known properties for supporting bone density and strength and general inflammatory response, Cholecalciferol is included in Core ALPHA because studies have shown that higher levels of vitamin D in men are correlated with higher levels of circulating testosterone.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eZinc (as zinc aspartate):\u003c\/strong\u003e Zinc deficiency is prevalent throughout the entire world, including the United States. Both severe and moderate zinc deficiencies are positively correlated with lower testosterone levels in men. And while zinc deficiency has been shown to lower your testosterone levels, zinc supplementation has been correlated with an increase in testosterone levels. Clinical research indicates that zinc deficiency reduces circulating luteinizing hormone and testosterone concentrations, may lower healthy levels of aromatase (increasing estrogen levels), and modifies sex steroid hormone receptor levels, thereby contributing to unhealthy hormone balance and male sexual function. Zinc supplementation with the aspartate form can support optimal zinc absorption and hormone balance.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-ALPHA-2020.jpg?v=1592389807\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_ALPHA_2020_FIN-OL.pdf?v=1638797400\"\u003eCore ALPHA Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/REFFERENCES-Core_ALPHA.pdf?v=1599729023\" target=\"_blank\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":53256737423670,"sku":"672975315009","price":247.62,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/ALPHAFRONT_ecf39cc6-bb45-4808-b28f-497843687f40.png?v=1762807509"},{"product_id":"core-load","title":"Load","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eGS4 Plus®\u003c\/strong\u003e - Effectively reduce measurements of plasma glucose\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGreen Coffee Extract\u003c\/strong\u003e - Increase nutrient partitioning capacity of myocytes\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBerberis Aristata\u003c\/strong\u003e - Help support healthy blood glucose metabolism\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGlucose Utilization Agent\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWe suggest that every other GDA bend the knee.\u003c\/p\u003e\n\u003cp\u003eCore LOAD has changed the meaning of “glucose-disposal agent” (GDA). While most GDAs on the market are single-pathway or single-mechanism formulas with sub-clinical serving sizes, LOAD targets multiple pathways and mechanisms through supra-clinical serving sizes.\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eServing size 6 capsules.\u003c\/li\u003e\n\u003cli\u003e30 servings per container.\u003c\/li\u003e\n\u003cli\u003eCarb-proof your diet.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eWith the advent of Core LOAD, Core Nutritionals has effectively changed the meaning of glucose-disposal agent (GDA). While most GDAs on the market are single-pathway or single-mechanism formulas with sub-clinical serving sizes, Core LOAD targets multiple pathways and mechanisms through either clinical or supra-clinical serving sizes. And most importantly, Core LOAD reaches these pathways through several non-redundant key ingredients that surgically target both glycogenic (glycogen-creating) and lipolytic (lipid\/fat tissue-mitigating) pathways.\u003c\/p\u003e\n\u003cp\u003eCore LOAD’s success as a GDA is due to its key ingredients – and specifically, the major pathways of glycogen storage and lipid metabolism they alter. Specifically, increasing the translocation of GLUT4 from the cell nucleus (its inner portion) to the periphery (its outer portion), thereby increasing the transportation of glucose into the cell; by inhibiting PPAR-Gamma2 and other critical lipogenic\/lipolytic genes and gene pathways; by altering the response to glucose ingestion at the cellular level; and by altering other critical messengers in both the glycogenic and lipolytic pathways.\u003c\/p\u003e\n\u003cp\u003eWhile other GDAs may target similar pathways, Core LOAD contains several ingredients that target these pathways through several different, non-redundant mechanisms. Essentially, we have taken every possible step to maximize your body’s glycogen storage, rather than relying on a single ingredient approach. Perhaps more importantly, we have utilized ingredients such a CGA (chlorogenic acid – a component of green coffee extract) in ways and serving sizes that blow the competition away. While serving sizes as small as 300mg of GGA have been shown to assist in healthy weight management, we included a savage 2g serving! That serving is also anywhere from 3-10x the serving size found in clinical research assessing CGA’s impact on glucose homeostasis and glycogen formation.\u003c\/p\u003e\n\u003cp\u003eNow, the critical question, not just for CGA, but for all glucose disposal agents is this: why is “disposing” of glucose important? What does that even mean. Let’s break this down in two ways. Let’s consider the first way as (attempting) to increase lean tissue; and the other avoiding non-lean tissue. When you consume carbohydrates, your body breaks those carbohydrates down until they eventually reach the plasma (blood) as glucose – blood sugar. Blood sugar is then diverted to cells for consumption in bodily processes.\u003c\/p\u003e\n\u003cp\u003eOur bodies divert glucose to both muscle cells (good) and fat cells (bad). In terms of the good, lean tissue-increasing effects, the key ingredients in Core LOAD will assist your body in creating glycogen. Think of glycogen like NOS for a car: a car can certainly run on fuel alone, but adding NOS to the mix greatly boosts the vehicle’s speed. For short bursts of maximal or near-maximal effort exercise, glycogen functions as your body’s fuel source – in addition to filling muscle bellies to provide them a “full,” 3D look. Maximizing glycogen storage also acts like an insurance policy against lipogenic (fat tissue-creating) action: the more glycogen stored in muscle, the less glucose shuttled to adipose cells or to the liver.\u003c\/p\u003e\n\u003cp\u003eIn terms of the bad, your body also diverts glucose to adipose (fat) cells – but not for energy consumption, but energy storage. Consider fat cell’s the long term storage bunker of your body: your body puts glucose there to withdraw it in times of need. Core LOAD’s key ingredients inhibit the process in non-redundant, synergistic ways – from inhibiting glucose uptake at the gastrointestinal level (to stabilize plasma glucose, which diminishes uptake in adipose cells) to diminishing the activity of key lipogenic (fat mass increasing) genes.\u003c\/p\u003e\n\u003cp\u003eWhen you combine both of these two kinds of action, you get Core LOAD: the new king of GDAs. We suggest that every other product bend the knee.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhysiological Properties and Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGreen Coffee Extract (\u003cem\u003eCoffea robusta\u003c\/em\u003e) (bean) (50% Chlorogenic acid)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCoffee is widely recognized as not only the most consumed psychoactive compound on earth, but perhaps also the most consumed plant material in general. Due to the extent of coffee consumption by humans, several species of coffee beans, along with their bioactive constituents, have been research targets for a number of therapeutic pathways. The most abundant polyphenol in coffee is Chlorogenic acid (CGA). An abundance of data suggests that CGA has numerous physiological properties, and that its most potent physiological effects are hypoglycemic (blood sugar-lowering) and lipolytic\/anti-lipogenic in nature. Recent evidence demonstrates that CGA is a powerful and novel glucose modulator, \u003cem\u003ein vivo\u003c\/em\u003e, in both healthy and diseased populations.\u003c\/p\u003e\n\u003cp\u003eResearch shows that one of CGA’s potential hypoglycemic mechanisms is insulin sensitization – in other words, making existing cells more sensitive to the glucose shuttling effects of insulin. In a trial on streptozotocin (STZ) (45 mg\/kgbw) nicotinamide-induced diabetic rats, a 5mg\/kgbw dose of CGA significantly mitigated the diabetic effects of STZ and caused an increase to glucose uptake. Of note, the 5mg\/kgbw dose of CGA used in the animal trial is significantly less than the mg\/kgbw serving size of CGA included in Core LOAD. (Assuming an average Core LOAD consumer bodyweight of 75kg.) An additional trial in obese Zucker rats demonstrated that CGA is capable of improving glucose tolerance and insulin resistance. The trial found that the CGA group had better glucose tolerance, higher insulin sensitivity index (ISI), and lower HOMA-IR (insulin resistance) index.\u003c\/p\u003e\n\u003cp\u003eA trial in healthy humans showed similar promise. Healthy, human subjects were challenged with an acute serving of CGA and then assessed for hepatic glucose output, blood glucose levels, and glucose tolerance. CGA induced a significant reduction in peak plasma glucose levels – an important fact, as glucose fluctuations and\/or chronically excessive blood glucose levels are associated with fat cell proliferation. Unlike the animal trial, however, the human trial hypothesized that CGA worked through a different, more novel mechanism: attenuating glucose absorption in the gastric uptake phase. In this trial, CGA effectively CGA functioned as \u003cem\u003eboth\u003c\/em\u003e an insulin sensitizing agent \u003cem\u003eand\u003c\/em\u003e a glycemic index lowering agent.\u003c\/p\u003e\n\u003cp\u003eIn addition to both the above mechanisms, CGA was shown to inhibit the activities of α-amylase and α-glucosidase – two enzymes responsible for metabolizing carbohydrates into saccharides. As a result, CGA again reduced postprandial (post-meal) blood glucose concentration. The potentially novel glycemic index-lowering and carbohydrate metabolism effects of CGA were confirmed in two further trials: one in which CGA intake significantly reduced fasting glucose and insulin levels in obese men, and another in which CGA lowered the glycemic impact (how quickly and to what degree plasma glucose was increased) and lowered blood glucose levels.\u003c\/p\u003e\n\u003cp\u003eCGA is an interesting compound due not only to its potent insulin-sensitizing and glycemic effects, but also its novel action on lipid metabolism. A 2006 trial found that CGA – in addition to caffeine and other polyphenols found in green coffee bean extract – suppressed body weight gain and the accumulation of visceral fat in mice. Again, the mechanism of action was quite unique: CGA was found to inhibit and delay the absorption of fat at the gastric uptake phase and reduce lipid metabolism in the liver.\u003c\/p\u003e\n\u003cp\u003eIn a separate trial on obese rates, CGA significantly reduced body weight, visceral fat mass (adipose tissue surrounding the internal organs), and plasma insulin concentrations. The authors of this trial hypothesize that, in addition to the profound effects on glucose metabolism noted above, CGA reduced body weight and fat mass due to increased fatty acid beta-oxidation activity and peroxisome proliferator-activated receptors alpha expression in the liver.\u003c\/p\u003e\n\u003cp\u003eIn sum, CGA is the perfect confluence of glycogenic, glycemic-impact lowering, insulin sensitizing, and anti-lipogenic factors. Its inclusion as a key ingredient in Core LOAD, at well above clinical serving sizes, functions to promote healthy blood glucose levels, healthy bodyweight, and healthy insulin release.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGS4 Plus\u003c\/strong\u003e\u003cstrong\u003e®\u003c\/strong\u003e\u003cstrong\u003e \u003cem\u003eGymnema sylvestre\u003c\/em\u003e Extract (leaves) (25% gymnemic acids)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eGymnema sylvestre \u003c\/em\u003eis a plant endemic to the tropical and sub-tropical regions of Southeast Asa, including India and China. In these countries, G. sylvestre functions as a treatment for many pathological conditions, including diabetes and hypercholesterolemia – in fact, the Ayurvedic name for G. sylevestre is “Gurmar,” or “destroyer of sugars.” The principle bioactives in G. sylvestre, gymnemic acids, are concentrated highly in the leaves and have been isolated and observed for their glucose shuttling properties.  \u003c\/p\u003e\n\u003cp\u003eIn a clinical trial in humans using a G. sylestre extract dietary supplement, 65 participants were administered G. sylvestre for 90 days. After the 90 day treatment, the participants were assessed for a number of biometrics, including prenadial (pre-eating) plasma glucose concentrations and HbA1c (haemoglobin A1c, a key marker for diabetes) levels. The researchers found that 90 days of supplementation with G. sylvestre lowered prenadial blood glucose by 11%, postpranadial glucose by 13%, and Hb1Ac by .8% (a seemingly small figure, but in fact statistically significant).\u003c\/p\u003e\n\u003cp\u003eIn another, small clinical study, fasting blood glucose levels significantly improved in a group of type II diabetes mellitus patients after receiving a 200mg extract of G. sylevestre (standardized for gymnemic acid) for 20 months.\u003c\/p\u003e\n\u003cp\u003eUnlike CGA, the mechanism(s) of action for G. sylevestre and gymnemic acid have not been precisely identified. Several trials in rats suggest that gymnemic acid’s structural similarity to glucose may have a role in its hypoglycemic effects; while still other trials suggest that, like CGA, gymemic acid may exert glucose uptake inhibitory effects at the intestinal level.\u003c\/p\u003e\n\u003cp\u003eWhatever the mechanism of action, however, the plant has demonstrated the ability to promote healthy blood glucose levels and assist in the management of a healthy body mass.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eBerbis aristata\u003c\/em\u003e\u003c\/strong\u003e\u003cstrong\u003e Extract (bark) (97% berberine)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eBerberis aristata\u003c\/em\u003e, is a shrub belonging to the family Berberidaceae and the genus Berberis, found in many parts of Eurasia and the Americas. The bark and bark extracts of the plant have been used traditionally as an antibacterial and antifungal preparation and as a hypoglycaemic, anti-diuretic, and vasodilator. The use of both B. aristata and its principal constituent, berberine, is widespread in traditional medicinal systems throughout history. Berberine is also now a prominent ingredient in dietary supplement formulations and a research target for numerous pathological conditions.\u003c\/p\u003e\n\u003cp\u003eThere is extensive literature demonstrating that the bark extract of B. aristata – and other plants containing a large proportion of berberine – is a potent AMPk agonist in skeletal muscle. Based on the pharmacological similarities between berberine and the anti-diabetic medicine metformin (with respect to AMPk activation), it is possible that berberine may promote an anti-catabolic state through increased expression of AMPk.  In a randomized, placebo-controlled and double blind trial, patients with Type II diabetes mellitus risk factors were administered an oral preparation of 650mg Metformin for 8 weeks to assess body composition and changes in insulin resistance. The Metformin group experienced an increase in lean weight from 57.05 +\/- 13.6 to 61.9kg +\/- 16.5 kg (p \u0026lt; 0.01). Though the standard deviation suggests a large variation in lean tissue gain, the results are taken to be statistically significant at the 99th confidence interval, suggesting a high level of statistical precision. This indicates, in other words, that 99% of the study population experienced a lean weight increase. It should be noted that, in comparison studies, berberine extracts (at doses of 500-1500 mg\/day) have outperformed metformin in key biochemical and physiological markers: including AMPk phosphorylation.\u003c\/p\u003e\n\u003cp\u003eThe human data – in both healthy and disease state populations – demonstrating berberine’s other physiological effects are numerous. A 2012 meta-analysis examined 14 randomized trials, containing 1068 patients, and assessed berberine’s efficacy in numerous biometrics, including resting plasma glucose levels, plasma insulin levels, body weight, body mass index, and reduction in fat mass and serum triglycerides and total cholesterol content. The aggregate data suggests that berberine performs \u003cem\u003eat least \u003c\/em\u003eas well as oral hypoglycemic agents (such as metformin) in these key metrics. Perhaps most interesting for users of Core LOAD, berberine showed the most promise \u003cem\u003ein combination \u003c\/em\u003ewith oral hypoglycemic agents. While berberine lowered fasting plasma glucose and insulin levels, reduced HbA1c, reduced triglyceride levels and reduced fat mass alone, and performed well in comparison, it was shown to potentiate the effects of pharmaceutical anti-diabetics – at times significantly, with further reductions in the above metrics of up to 20%.\u003c\/p\u003e\n\u003cp\u003eEffectively, this means that berberine is not only a potent glucose disposal agent on its own, but also \u003cem\u003emakes other glucose disposal agents more effective\u003c\/em\u003e.\u003c\/p\u003e\n\u003cp\u003eLike CGA, berberine is not only a glucose disposal agent but a potent anti-lipidemic agent. In \u003cem\u003ein vitro \u003c\/em\u003emodels, researchers examined the expression of a number of adipocyte-specific genes including fatty acid synthase (FAS), ADD1\/SREBP1c (adipocyte determination and differentiation–dependent factor 1\/sterol regulatory element–binding protein 1c), peroxisome proliferator–activated receptor (PPAR)γ, and 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), and found them to be reduced in various WAT (white adipose tissue) deposits of berberine-treated mice. This data suggests that daily ingestions of beberine may potently inhibit a constellation of genes that are responsible for both depositing and converting lipids into fat tissue, and genes responsible for their mobilization (use for fuel) in response to exercise. In brown adipose tissue, the expression of PPARα mRNA (a receptor protein largely involved in lipolysis – the breakdown of fat tissue) also increased dramatically, while the mRNA of lipogenic genes such as FAS was reduced. Additionally, expression of PPARγ coactivator-1, a key regulator of several mitochondrial genes involved in adaptive thermogenesis, was substantially increased, suggesting berberine’s induction of AMPk expression leads to an inhibition of the proliferation and hypertrophy of fat cells.\u003c\/p\u003e\n\u003cp\u003eAgain, like CGA, berberine possesses numerous, beneficial physiological and metabolic properties: including the healthy regulation of blood glucose and accumulation of fat tissue. But perhaps most importantly, the evidence suggests that berberine may potentiate the effects of every other ingredient in Core LOAD.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBanaba Extract (\u003cem\u003eLagerstroemia\u003c\/em\u003e \u003cem\u003especiose\u003c\/em\u003e)(leaf)(20% corosolic \u003cem\u003eacids)\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eLagerstroemia speciosa \u003c\/em\u003eis a flowering tree of the Lagerstroemia genus that is native to large portions of south east Asia, India and the Phillipines, and its bark and leaves have a historical tradition in folk medicine for the treatment of diabetes mellitus. Banaba (L. speciosa’s common name) has been used as a folk medicine to treat diabetes in various parts of the world, primarily southeast Asia. The hypoglycemic effect of aqueous (hot water) and methanol extracts have been demonstrated in many human studies. Most studies have focused on corosolic acid, the primary bioactive constituent of L. speciosa – and the compound for which Core LOAD’s banaba is standardized.\u003c\/p\u003e\n\u003cp\u003eA 12-week lifestyle intervention study, involving 56 subjects consuming a dietary supplement containing banaba, taken prior to each meal, measured body mass at the conclusion of the trial. At the end of 12 weeks, the subjects had lost an average of 6.29 kg (13.8 lb) including 3.72 kg (8.2 lb) body fat as determined by a bioelectric impedance body fat analyser.\u003c\/p\u003e\n\u003cp\u003eIn a separate, smaller study, 12 nondiabetic subjects with a baseline blood glucose level of 104 mg\/dL were given a soft gel capsule daily for 2 weeks containing 10 mg corosolic acid as a Banaba extract standardized to 18% corosolic acid. A 12% decrease in fasting glucose levels, as well as 60 min postprandial blood glucose levels, was observed after 2 weeks of administering the product. The authors also reported an average three-pound weight loss after the two weeks.\u003c\/p\u003e\n\u003cp\u003eIn an unpublished study using the same soft gel product containing 10 mg corosolic acid, 100 subjects with prediabetes or type 2 diabetes were enrolled. Half the subjects were given one soft gel containing the corosolic acid-standardized Banaba extract and the other half received a placebo for 30 days. Both fasting and 2 h postprandial blood glucose levels in the treated group decreased by 10% relative to the control (placebo) group. Also reported was an improvement in diabetic symptoms including a decrease in thirst, drowsiness, and hunger. Furthermore, no adverse effects were observed, with no changes in blood pressure, liver or kidney function, blood cell count, or hemoglobin.\u003c\/p\u003e\n\u003cp\u003eLastly, a study involving 31 subjects in a double-blind cross-over design were given a capsule containing 10 mg corosolic acid or a placebo 5 min before a 75g oral glucose tolerance test. Blood glucose levels were measured at 30 min intervals for 2h. The authors reported that corosolic acid treatment resulted in lower blood glucose levels from 60 to 120 min compared with controls, the difference being statistically significant (P \u0026lt; 0.05) at the 90 min time point. According to the authors, the corosolic acid that was used was 99% pure, thus indicating that the blood sugar lowering effect was specifically due to the corosolic acid. In the context of Core LOAD, the AUC (area under curve) demonstrated in this trial is important – as it demonstrates that corosolic acid exerts glucose stabilizing effects over a long time period (such as immediately before-to-after an intense workout).\u003c\/p\u003e\n\u003cp\u003eThe above clinical studies demonstrate that Banaba extract, Banaba extract standardized to corosolic acid, and corosolic acid itself, decrease fasting as well as postprandial blood glucose levels in humans. A decrease in blood glucose levels has been observed within 2 h of dosing, and the decrease is typically in the range of 10–15%, although a decrease of 30% has been reported.\u003c\/p\u003e\n\u003cp\u003eThe ability to corsolic acid to positively regulate healthy plasma glucose levels makes it a key addition to Core LOAD’s glucose disposal agent lineup.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-LOAD2020.jpg?v=1582880736\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/core_LOAD_8.5x3.25_FIN-OL_508d5ee4-8215-4de9-83dc-0ec4f318d9fd.pdf?v=1643987924\"\u003eCore LOAD Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core-LOAD-Product-References.pdf?9608423075920391763\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":53256737685814,"sku":"672975009700","price":209.52,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/LOAD_FRONT_12ab340f-bfe7-4aac-a324-fe9a3ecf18cd.png?v=1762807511"},{"product_id":"core-omega","title":"Omega","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eEPA\/DHA\u003c\/strong\u003e - May support normal brain function\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEPA\/DHA\u003c\/strong\u003e - Superior triglyceride form\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEPA\/DHA\u003c\/strong\u003e - Produced under nitrogen barrier\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003ciframe src=\"https:\/\/www.youtube.com\/embed\/6820HCr19hI\" width=\"560\" height=\"315\"\u003e\u003c\/iframe\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHigh Purity Fish Oil\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThis is not just another fish oil product – it is \u003cem\u003ethe\u003c\/em\u003e fish oil product.\u003c\/p\u003e\n\u003cp\u003eOMEGA contains high levels of the all-important DHA and EPA, with 480mg and 720mg respectively in each serving. Produced under a nitrogen barrier, this is the purest fish oil product possible.\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e2 soft gels per serving.\u003c\/li\u003e\n\u003cli\u003e60 servings per container.\u003c\/li\u003e\n\u003cli\u003eHeart and brain health.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eWhen it comes to dietary supplement purchases, consumers are discerning and exact: the dose, form, extract, standardization and more must precisely conform to their standards. The brand matters, the compounds matter, and how those compounds are produced matters.\u003c\/p\u003e\n\u003cp\u003eBut when it comes to the basic supplements, the staples, most people have the attitude, “It’s all the same.” They travel to their local supplement store, browse quickly online, or grab whatever’s on the grocery store shelves and call it a day. Why? Shouldn’t the staples, something you are placing in your body everyday, be purchased with as much exactitude as the exotic stuff? And more importantly, shouldn’t the staples be produced with as much care and attention to specifics as the exotic stuff?\u003c\/p\u003e\n\u003cp\u003eAt Core, we think they should – and that’s why we’ve released OMEGA. OMEGA is a fish oil supplement, the Core way. What does that mean? Well, it means carefully selecting a fish oil manufacturer for our product that produces its fish oils under the all important nitrogen barrier – a manufacturing technique that greatly reduces the chance for oxidation, significantly expands the product’s effective shelf life, and all but eliminates any “fish” taste or smell from the oil. It also means ensuring that our fish oil product contains high levels of the all-important DHA and EPA, with 480mg and 720mg respectively in each serving. Lastly, it means using the purified triglyceride form, rather than the more common ethyl esters.\u003c\/p\u003e\n\u003cp\u003eIn total, this is not just another fish oil product – it is the fish oil product.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhysiological properties and effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNitrogen Barrier Production \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eOil derived from marine animals – commonly referred to as “fish oils” – are widely consumed for the high amounts of polyunsaturated fatty acids (such as DHA and EPA) that they contain and the potential health benefits that these fatty acids confer. Unfortunately, polyunsaturated fatty acids are notoriously unstable: they are composed of double-bonds between carbon atoms, a chemical structure that is notoriously susceptible to oxidation. (Oxidation is the process of producing oxygen species as a consequence of a compound’s exposure to oxygen.)\u003c\/p\u003e\n\u003cp\u003eFor fish oil, oxidation has a number of deleterious effects – principally, the production of hydroperoxides (the first step in oxidation) and secondary oxygen products not only produce the rancid, “fish” smell typically associated with lower quality fish oil products; but perhaps more importantly, in breaking the double bond structure of the fish oil, these oxygen species degrade the integrity of the product and thus reduce their potential health benefits. The oxidation degradation is unfortunately widespread. One study found that 50% of 171 fish oil supplements in Canada exceeded the limits for at least one measure of oxidation, and 39% exceeded the international voluntary safety recommendations for total oxidation (TOTOX value).” Another study found that approximately 29% of fish oil supplements in the United States similarly exceeded recommended values.\u003c\/p\u003e\n\u003cp\u003eLuckily, research has shown that reducing the exposure of fish oils to oxygen and environmental factors (humidity and temperature fluctuations) during the production process can significantly mitigate oxidation. One of the most effective ways to reduce oxygen exposure is to blanket the oil, as soon as its processed and produced, in an inert gas such as argon or nitrogen – thereby preventing the fish oil from coming into contact with oxygen at all. While exact values will vary by product, research has shown that both primary oxidation (the production of hydroperoxides, measured in peroxide value, PV) and secondary oxidation (measured in TOTOX (total oxidation value) and a-nsidine values) are vastly reduced through a nitrogen blanket or barrier. \u003c\/p\u003e\n\u003cp\u003eIn sum, producing fish oils under a nitrogen blanket or barrier not only reduces the rancid smell typically associated with fish oil products; but vastly extends their shelf life and integrity.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cbr\u003eTriglycerides vs Ethyl Ester Forms\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWe have established that \u003cem\u003ehow \u003c\/em\u003efish oils are produced may impact their viability as a dietary supplement. But the production process is not the only salient factor in fish oil efficacy and viability – the \u003cem\u003eform \u003c\/em\u003ethat a fish oil takes is paramount, as well. Specifically, the differences between triglycerides and ethyl esters may be formative in how fish oils are absorbed and confer their potential health benefits.\u003c\/p\u003e\n\u003cp\u003eFirst, a little primer on what triglycerides and ethyl esters are. Triglycerides are a molecular form common to almost all plant and animal species: a glycerol backbone with three fatty acids (in the case of fish oils, EPA and DHA) attached to them. For example, the “stuff” of human adipose (fat) tissue is triglycerides. Ethyl Esters, on the other hand, lack a glycerol backbone – they are a single fatty acid molecule attached to an ethanol molecule. Unlike triglycerides, ethyl esters are not a natural molecular form and formed solely through chemical synthesis.\u003c\/p\u003e\n\u003cp\u003eWhile the difference between triglycerides and ethyl esters as applied to fish oil may seem academic, it in fact has profound implications for the absorption and bioavailability of these oils. In very condensed form, the issue is twofold: how the fish oil is taken up into the bloodstream (absorption) and how it is made available to cells once that has occurred (bioavailability). In both contexts, there is evidence that triglycerides are superior to the ethyl ester form.\u003c\/p\u003e\n\u003cp\u003eFor bioavailability, the issue is how the small intestine breaks down each form of fish oil. As a natural product, our bodies are intrinsically capable of breaking down triglycerides via bile salts and pancreatic lipase. Once ingested, pancreatic lipase and bile salts are released, and in the small intestine, the triglyceride is broken down into so-called emulsion droplets – which can then easily be broken up, detaching the two fatty acid molecules from the glycerol backbone. Not so with ethyl esters. Not only is pancreatic lipase (by some estimates) 50% less effective in breaking down ethyl esters; but once digested, ethyl esters must be \u003cem\u003econverted \u003c\/em\u003einto triglycerides through the liberated fatty acids attaching to a glycerol molecule. Essentially, your body must reverse the entire metabolism of ethyl esters, then go through the normal triglyceride metabolism.\u003c\/p\u003e\n\u003cp\u003eThe biochemical differences between triglycerides and ethyl esters have been demonstrated in trials examining bioavailability and absorption efficiency. One study found that, when ingested in triglyceride form, EPA and DHA levels were 340% and 271%, respectively, as compared to the ethyl ester form. Additional research has found a 25% increase in plasma EPA and DHA levels over a six month period; that ethyl esters are “poorly absorbed” by man; and that triglyceride form fish oils suffer less oxidation (on shelf) than the ethyl ester form.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEPA and DHA\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNow that we know why producing fish oils under nitrogen barrier protects the integrity of fish oil, and why triglycerides are superior to ethyl esters, we have only one major question left: \u003cem\u003ewhat benefits do fish oils (specifically, EPA and DHA) pose to humans\u003c\/em\u003e?\u003c\/p\u003e\n\u003cp\u003eEicosapentaenoic acid (EPA) and cocosahexaenoic acid (DHA) have myriad health benefits, but their best-studied (and approved by the FDA) use is to balance and maintain healthy triglyceride levels. Triglycerides, as we mentioned, are produced naturally by most animals. They are necessary for a wide range of physiological function, but their overabundance is implicated in a number of pathological conditions. As a consequence, ingesting external forms of triglycerides – such as fish oils – can help balance triglycerides and maintain healthy levels. In perhaps the most robust meta-analysis to date, researchers examined 11 randomized human trials, comprised of 485 total individuals with a mean age of 25 to 49. The meta-analysis found robust evidence that DHA, specifically, exerts a significant triglyceride lowering and balancing effect. A similar meta-analysis focused on EPA found that its effects were comparable to DHA.\u003c\/p\u003e\n\u003cp\u003eBoth of these polyunsaturated fatty acids are best known for their triglyceride-lowering function, each exerts other interesting effects as well. Significant evidence suggests that EPA and DHA may mitigate the production of pro-inflammatory cytokines, molecules responsible for inducing the inflammation cascade in the body. Others studies suggest high levels of brain DHA are associated with verbal fluency and memory in healthy, normal adults – with one study finding that 6 months of DHA supplementation in young, healthy adults increased working memory assessed by recall.\u003c\/p\u003e\n\u003cp\u003eOne of fish oil’s (specifically, EPA’s) effects that may be of interest to fitness and physique athletes is its ability to induce AMPk (adenonsine monophosphoate kinase). AMPk, otherwise known as the “master metabolic switch,” is a heterotrimeric enzyme responsible for energy catabolism in muscle and fat cells. When activated, AMPk increases lipolytic (the catabolism of fat tissue) signaling as a means of energy provision. Several studies demonstrate that high levels of EPA indirectly stimulate AMPk activation via decreasing PPARy.\u003c\/p\u003e\n\u003cp\u003eThough less well-studied or confirmed, emerging research suggests that DHA and EPA levels may be formative in maintaining healthy and normal moods, due to altering certain neurological proteins. These literature require follow-up and replication, but show promise in establishing a new purpose for DHA and EPA supplementation.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-OMEGA-2020.jpg?v=1586243286\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_OMEGA_8.5x3.25_FIN-OL.pdf?v=1639556455\"\u003eCore OMEGA Label \u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core-OMEGA-Product-References.pdf?3889446998475729901\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":53256737751350,"sku":"672975009724","price":171.43,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/OMEGAFRONT_b2006f34-3757-4aba-af8c-92ede690609c.png?v=1762807512"},{"product_id":"core-test","title":"Test","description":"\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eCalcium D-Aspartic Acid\u003c\/strong\u003e - Supports Health Testosterone Levels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKSM-66®\u003c\/strong\u003e - Aids in Cortisol Reduction to Help with Body Composition\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBulbine Natalensis\u003c\/strong\u003e - Increase in Overall Vitality\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003ciframe src=\"https:\/\/www.youtube.com\/embed\/fr4Kgw3-jk4\" width=\"560\" height=\"315\"\u003e\u003c\/iframe\u003e\u003c\/p\u003e\n\u003cp\u003eIf you don’t know your best yet, you’ll certainly know it when Core TEST helps you reach it.\u003c\/p\u003e\n\u003cp\u003eWe’ve scoured the literature and eventually created a formula packed with effective ingredients targeting multiple pathways of healthy testosterone support. This is the best, most comprehensive, multi-pathway testosterone support product on the market.\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e1 scoops per serving.\u003c\/li\u003e\n\u003cli\u003e28 servings per container.\u003c\/li\u003e\n\u003cli\u003eHealthy testosterone support.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eBeing at your best, your peak, isn’t a subjective state of mind or a feeling one has – it’s a physiological state, a confluence of metabolic factors that result in the best, most peak, most alpha version of you stepping out into the world and into the gym every day. Are you doing what’s necessary to be there?\u003c\/p\u003e\n\u003cp\u003eIf not, then Core has your back with the newest evolution in healthy testosterone and male support: Core TEST. By now, you already know the drill: we take the best ingredients, backed by clinical research, and include them in serving sizes actually reflected in the literature. Core TEST is no different.\u003c\/p\u003e\n\u003cp\u003eWe’ve scoured the literature, alpha and beta tested more formulas than you can count, and eventually created a formula packed with actually effective ingredients targeting multiple pathways of healthy testosterone support. Calcium DAA, one of the best known support supplements on the market, backed by clinical research in humans. KSM66, an ingredient with a long history of use in traditional medicine now backed by an unimpeachable record of cortisol reduction, healthy testosterone support, and hormone optimization. We could’ve given you KSM66 and left it at that – the ingredient is that good. But we didn’t. We included Bulbine natalensis, Tongkat Ali, and a potent estrogen modulator in Pine extract to cap off the savagery. This is the best, most comprehensive, multi-pathway testostone support product on the market.\u003c\/p\u003e\n\u003cp\u003eAll in all, we have created a formula that you’ll know is working. If you don’t know your best yet, you’ll certainly know it when Core TEST helps you reach it.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003cstrong\u003ePhysiological Properties and Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCalcium D-Aspartic Acid\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eD-Aspartic Acid, the d isomer form of the amino acid aspartate, is an amino acid that is found naturally in several endocrine glands, including the testes and pituitary. While the correlation between DAA and testosterone production has been clinically documented, research indicates several possible mechanisms for these effects.\u003c\/p\u003e\n\u003cp\u003eIt’s likely that DAA acts as a neuromodulator influencing several pathways that govern the reproductive system, particularly testosterone production. Some studies indicate that DAA’s concentrated presence in the hypothalamus, pituitary, and testes identify this protein as an up-regulator of gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), growth hormone (GH), and testosterone. Some studies have found that DAA also stimulates a protein called StAR. StAR is necessary for the cholesterol transport in the cell that is needed for testosterone production. Further, its role in modulating the sexual drive implicates DAA assists nootropic activity, supporting health levels of dopamine and serotonin. Balanced levels of dopamine and serotonin have a range of significant benefits.\u003c\/p\u003e\n\u003cp\u003eThe existing research in human males suggests these mechanisms of action have plausible, real world activity. A six-month trial in average men, for example, saw increases to circulating testosterone of 30-60%. The increase over baseline persisted for the entirety of the trial in certain subjects, suggesting that DAA does not lose its effects over time or with repeated administration.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eKSM-66® Full-spectrum Ashwagandha root extract (5% Withanolides)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eWithania somnifera Dunal,\u003c\/em\u003e colloquially known as Winter Cherry or Indian Ginseng, is an herb that features prominently in the traditional Indian medicinal system of Ayurveda. Known as Ashwagandha in Ayurveda, \u003cem\u003eWithania somnifera\u003c\/em\u003e is a critical ingredient in various Ayurvedic tonics and tinctures prepared as a traditional remedy for the treatment of various ailments.\u003c\/p\u003e\n\u003cp\u003eRecently identified as a potent adaptogenic and target for therapeutic applications, Ashwaghanda has been the subject of numerous animal, pre-clinical, and clinical trials designed to examine its potential effects as an antioxidant, anti-carcinogenic, anxiolytic, antibacterial, antifungal, and immonumodulating compound. Ashwaghanda’s broad therapeutic potential is hypothesized to be the result of its robust phytochemical profile, including a wide swath of alkaloids, sitoindosides, and the highly biologically active withanolide group. As the principally biologically active compounds within Ashwaghanda, withanolides such as withanone, withaferine A, withanolides A, D, and G have been identified, isolated, and extensively studied in the various applications noted above.\u003c\/p\u003e\n\u003cp\u003eIn recognition of the potential physiological benefits of withanolides, Core Nutritionals selected KSM-66® to include in its HARD formula. KSM-66® is a full-spectrum Ashwaghanda extract, standardized for 5% withanolides – meaning that KSM-66® not only includes the full range of biologically active compounds within Ashwaghanda, but also that it contains the highest currently available concentration of the principally active withanolides (5%).\u003c\/p\u003e\n\u003cp\u003eThe high concentrations of withanolides within KSM-66® has resulted in encouraging results in a number of human, clinical trials – particularly considering many of these trials were conducted using the methodological gold standard of randomization, double-blind delivery, and placebo control. Amongst the most impressive results contained in these trials:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eA 27.9% reduction in serum cortisol levels, measured over 60 days in a trial featuring 64 chronically stressed adults.\u003c\/li\u003e\n\u003cli\u003eStatistically significant increases to endurance and stamina, as measured by VO2 max, in a clinical trial featuring 50 healthy, exercise-trained adults.\u003c\/li\u003e\n\u003cli\u003eIncreased measures of well-being as reported by self-assessment scales, included in both the clinical trials mentioned above.\u003c\/li\u003e\n\u003cli\u003eStatistically significant increases in serum testosterone levels in a clinical trial featuring 68 infertile men.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThough each of these results is impressive, perhaps the most significant for Core TEST is a study involving KSM66® and testosterone. 46 male patients were treated with KSM66® or placebo for 90 days, with measurements of serum hormone levels taken at the end of the 90 day treatment. The study established that 675mg of KSM66 over 90 days had a statistically significant impact on healthy testosterone production in males, as compared to placebo. The same study also found an increase in healthy production of LH (luteinizing hormone), suggesting that KSM66’s method of action is at the pituitary level.\u003c\/p\u003e\n\u003cp\u003eTo put it the simplest way possible, cortisol’s chief functions involve either turning on, or shutting off, the very things we as fitness enthusiasts want to avoid or turn on, respectively!\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eBulbine natalensis\u003c\/em\u003e\u003c\/strong\u003e\u003cstrong\u003e (stem) Extract (10:1)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBulbine natalensis is a herb endemic to Southern African that has historically been used as an aphrodisiac in traditional medicine preparations. Recent animal research has demonstrated that the herb has healthy testosterone supporting effects in rats and may also elicit positive effects on cognition.\u003c\/p\u003e\n\u003cp\u003eWhile Bulbine natalensis’ method of action is not certain, research conducted on rats suggests its testosterone-support functions stem from an increase in LH (luteinizing hormone). Luteinizing hormone is a hormone released by the pituitary gland to signal the Leydig cells in the testes to produce testosterone. The animal trial demonstrating an increase in LH also demonstrated an increase in rat testosterone levels at 14 days. The study revealed an increase in circulating testosterone of 40%.\u003c\/p\u003e\n\u003cp\u003eIn these same trials, an aqueous extract of the herb was found to dose-dependently lower estrogen levels in male rats. Research has not established whether the estrogen-lowering effects of Bulbine natalensis are a cause or consequence of its ability to support healthy testosterone levels.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eEurycoma longifolia\u003c\/em\u003e\u003c\/strong\u003e\u003cstrong\u003e (root) Extract (100:1)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe name \u003cem\u003eEurycoma longifolia \u003c\/em\u003eis probably familiar to most within the bodybuilding and fitness community, as it has a long history of use as an aphrodisiac supplement. Also known as Tongkat Ali, Malaysian Ginsgeng, and Longjack, the herb is found in temperate regions of SouthEast Asia and has been used for centuries as an aphrodisiac in medicinal systems local to those regions.\u003c\/p\u003e\n\u003cp\u003eWestern research has begun to establish that \u003cem\u003eEurycoma longifolia’s \u003c\/em\u003edoes in fact have an effect on libido, at least in animal trials. Trials in rats have demonstrated Tongkat Ali increased measures of sexuality (mounting frequency, latency to ejaculation and partner selection), while \u003cem\u003ein vitro \u003c\/em\u003eassays have identified pro-erectile bioactive compounds.\u003c\/p\u003e\n\u003cp\u003eThough more research is required to establish Tongkat’s aphrodisiac and\/or pro-erectile effects in humans, the existing animal research is fairly consistent in suggesting the herb’s effects in these areas.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePine Extract (rosin) (97% abieta-8,11,13-trien-18-oic acid)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAbieta-8,11,13-trien-18-oic acid, more commonly known as Dehydroabietc acid or DHAA, is a terprene compound isolated from several plants and trees, including certain species of Pine. Certain assays have also isolated DHAA from resin of \u003cem\u003eCommiphora myrrha.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eWhile limited in amount, the research that exists on DHAA is promising. Prior to discussing this research, it may be useful to explain the research term IC50. IC50 is a measurement in estrogenic assays that describes the amount of a given aromatase-inhibiting compound needed to reduce half (or 50%) of the aromatase enzyme. The aromatase enzyme, in turn, is the enzyme responsible for converting testosterone to estrogen. The prescription drug Formestane, for example, has an IC50 value of 0.6 mu – with a lower value indicating a more potent compound. (The less compound needed to reduce aromatase by 50%, the more powerful it is).\u003c\/p\u003e\n\u003cp\u003eDHAA’s IC50 value – according to the available research – is 0.3 mu, suggesting that it has potent activity against the aromatase enzyme. While the research exhibiting DHAA’s precise IC50 value is \u003cem\u003ein vitro\u003c\/em\u003e, animal research does exist to suggest a practical, real-world effect. Agricultural studies in fish examining DHAA as an environmental factor suggest that DHAA \u003cem\u003esignificantly \u003c\/em\u003eand level-dependently reduces circulating estrogen in certain fish species.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/supplement-facts-TEST-2020.jpg?v=1597301883\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_TEST_2020_PRIMAL_PUNCH_FIN-OL.pdf?v=1639562855\"\u003ePrimal Punch Label\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_core_TEST_2020_PRIMAL_BLACK_LIGHTNING_FIN-OL_compressed_1.pdf?v=1639562730\"\u003eBlack Lightning Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core-TEST-Product-References.pdf?12965010941871190252\"\u003eDownload References\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Primal Punch","offer_id":53256737816886,"sku":"672975315023","price":257.14,"currency_code":"AED","in_stock":false},{"title":"Black Lightning","offer_id":53256737849654,"sku":"672975315030","price":257.14,"currency_code":"AED","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/TEST_BL_Front-1_6e3d090a-50a0-464a-a7c3-3c30713ee576.png?v=1762807514"},{"product_id":"creatine-monohydrate","title":"Creatine Monohydrate","description":"\u003cp\u003eCreatine monohydrate has been shown to:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003eIncrease muscle mass\/size (when used in conjunction with a resistance training program).\u003c\/li\u003e\n\u003cli\u003eImprove strength, power, and performance in repetitive bouts of brief, high intensity physical activity (e.g. sprints, jumping).\u003c\/li\u003e\n\u003cli\u003eDecrease muscular fatigue in response to high intensity exercise (weight training).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eTHIS PRODUCT IS INFORMED SPORT CERTIFIED\u003c\/h3\u003e\n\u003cp\u003eThis certification ensures that Creatine Monohydrate, is tested for banned substances and meets the highest standards for quality, safety, and transparency. This certification can provide elite athletes and average gym goers with the confidence that every batch is free from contaminants and complies with WADA, as well as other sports league regulations.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eEvery write-up crafted about creatine, including ours, should simply say: it’s creatine, enough said. This is, after all, the most studied, the most anecdotally verified, and the most well known dietary supplement available to us – and with good reason. The evidence on creatine truly does, “speak for itself.”\u003c\/p\u003e\n\u003cp\u003eWith that said, much hoopla has arisen over the past few years regarding how to take creatine, when to take creatine, which form is the best, and so on. We have simplified that for you, and provided you the best, highest purity creatine monohydrate on the market at a competitive price – unbeatable, we’d say!\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003ch3\u003eScience\u003c\/h3\u003e\n\u003cp\u003eCreatine is perhaps the most studied and verified of all dietary supplements, earning its moniker as the, “grandfather of supplements.” Through a number of enzymatic and cellular steps, creatine is first metabolized into a compound known as phosophocreatine, and eventually into a compound known as ATP (adenosine triphosphate) – the so-called, “energy currency” of the human body. As a dietary supplement, the use of creatine over extended periods of time has been linked to a wide-range of physiological benefits, including: cell volumization, increased delivery of plasma (blood) nutrients to the cell, an increase in skeletal muscle total mass and protein synthesis, decrease in muscular fatigue, and increased endurance.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/commodities-supp-facts-2020-CREATINE.jpg?v=1597909681\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/Core_Creatine_P65_FIN-OL.pdf?v=1644226888\"\u003eCreatine Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":53256738046262,"sku":"672975315344","price":114.29,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/Creatine_UF_Front_b6fd7d25-1e51-4c45-bee2-21e6e84fd272.png?v=1762807515"},{"product_id":"acetyl-l-carnitine","title":"Acetyl-L-Carnitine","description":"\u003cp\u003eAcetyl-L-carnitine has been shown to:\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003ePromote fatty acid and carbohydrate metabolism\u003c\/li\u003e\n\u003cli\u003eBe involved in brain processes such as mood and memory\u003c\/li\u003e\n\u003cli\u003ePlay a key role in protein synthesis\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003eAcetyl-L-Carnitine (ALCAR) is a little bit like your 401K: you need it, you know you should pay attention to it, but it’s not exactly the sexiest topic. We know; we feel you! But we also know that ALCAR is one of the most fascinating, useful, and physiologically exciting workout supplements on the planet. You’re hard-pressed to find a single other ingredient that is involved in so many critical bodily processes: fatty acid and carbohydrate metabolism, neurotransmission, exercise performance and capacity, brain function – the list goes on! So, like your 401K contribution, don’t forget to pay into your ALCAR fund. \u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003ch3\u003eScience\u003c\/h3\u003e\n\u003cp\u003eL-carnitine is a derivative of the amino acid lysine and, as certain conditions outpace the body’s ability to produce it, l-carnitine is considered a conditionally essential amino acid. While endogenous biosynthesis of l-carnitine from the amino acids lysine and methionine is sufficient for essential processes – along with dietary sources of carnitine from protein-rich red meat, for example – dietary supplementation of carnitine may pose benefits in certain physiological conditions. \u003c\/p\u003e\n\u003cp\u003eUnfortunately, due to excess metabolism of l-carnitine by microorganisms in the small intestine, exogenous supplementation with oral l-carnitine has proved ineffective. ALCAR, an acetylated version of l-carnitine, has considerably higher oral bioavailability, due likely to only partial hydrolytic metabolism. Once in the bloodstream, ALCAR plays a fundamental role in the production of energy, acting as the catalyst for the beta-oxidation of long chain fatty acids by the mitochondria; regulating the CoA to Acyl-CoA ratio (necessary for the production of ATP); and the metabolism of carbohydrates. ALCAR also is an excitatory agent for neurons, increases neuronal transmission, and increases the production of neurotransmitters and neurohormones such as dopamine and serotonin.\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/commodities-supp-facts-2020-ALCAR.jpg?v=1597908997\"\u003e\u003c\/p\u003e\n\u003cp\u003esplit\u003c\/p\u003e\n\u003cul class=\"ticks\"\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/2440\/0931\/files\/P65_Alcar_2020_7.5x2.5_FIN-OL.pdf?v=1644226026\"\u003eAcetyl-L-Carnitine Label\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Core Nutritionals","offers":[{"title":"Default Title","offer_id":53256738242870,"sku":"672975315405","price":114.29,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/1033\/1702\/files\/ACETYL_FRONT_eefb6e38-0507-46c2-9d54-745f9b1eb1ce.png?v=1762807518"}],"url":"https:\/\/www.corenutritionals.ae\/collections\/all-products.oembed?page=2","provider":"Corenutritionalsae","version":"1.0","type":"link"}